Navigation Links
Therapy may block expansion of breast cancer cells
Date:11/5/2008

Philadelphia, Penn. November 05, 2008 Breast cancer stem cells are known to be involved in therapy resistance and the recurrence of cancerous tumors. A new study appearing in Clinical and Translational Science shows the mechanisms governing stem cell expansion in breast cancer (called Notch activity), and finds that therapy targeting a protein called cyclin D1 may block the expansion of cancerous stem cells.

The study, conducted by Dr. Richard Pestell and colleagues at Thomas Jefferson University, was the first to show that cyclin d1 is required for breast cancer growth in mice. As cyclin d1 is known to be over-expressed in human breast cancer, the findings may explain how cyclin d1 contributes to breast tumor growth, and provide the rationale for targeted therapies at cancerous stem cells in humans.

"Breast and other cancers are maintained through a population of cancer stem cells. By specifically targeting cancer stem cells we hope to reduce recurrence and improve therapy responses," says Pestell.

Cancer arises as a result of the accumulation of multiple genetic lesions that ultimately result in unregulated cell cycle, and Notch activity is a key determinant of the cellular development and differentiation related to this process. As Notch signaling is activated in human breast cancer, (and a negative regulator of Notch signaling reduces the disease), the molecular mechanisms regulating Notch activity are of fundamental importance for future therapy.


'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1

Related medicine news :

1. TomoTherapy Completes Acquisition of Linear Accelerator Manufacturer in China
2. Extended Therapy Helps Drug-Addicted Teens
3. Central California Doctors Now Using Fast RapidArc(TM) Radiotherapy Technology to Battle Cancer
4. SANCUSO(R), the First and Only Patch for Preventing Nausea and Vomiting in Chemotherapy Patients, Now Available
5. Educational Symposium to Present Panel Discussion on Melanoma Treatments and Immunotherapy
6. Cancer Patients in Southeastern Florida Now Benefiting From RapidArc(TM) Radiotherapy Treatments
7. NxStage(R) Achieves Milestone with 3,000 End-Stage Renal Disease Patients Receiving Daily Home Hemodialysis Therapy
8. BiomagScience Introduces Breakthrough Health Therapy Kits
9. Philips Introduces New, Advanced Light Therapy Device to Offer Quick Relief from Winter Blues
10. The Physical Therapy Profession Remains in High Demand
11. Radiation Oncology Experts from 16 Countries Attend Technical University of Munich's International Conference on TomoTherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... WA (PRWEB) July 11, 2014 College ... within one week of injury, but developed recurrent instability ... at the American Orthopaedic Society for Sports Medicine’s ( ... guide team physicians in providing the most optimal treatment ... who suffered an anterior shoulder instability event, and found ...
(Date:7/11/2014)... Re-tearing a repaired knee Anterior Cruciate Ligament (ACL) ... presented today at the American Orthopaedic Society for Sports ... education regarding modifiable risk factors may minimize the chance ... suggests that a few risk factors such as, age, ... to the possibility of re-injury," said lead author, Christopher ...
(Date:7/11/2014)... Bethpage, NY (PRWEB) July 11, 2014 Wild ... Kullen, is proud to announce they are opening a fifth ... , Wild by Nature offers one of the largest selections ... of people diagnosed with celiac disease, these stores have become ... a gluten-free diet. , Gluten sensitivity, and gluten intolerance, is ...
(Date:7/11/2014)... BellasDress, the experienced dressmaker in the ... suppliers when it comes to beach wedding dresses ... of beach wedding outfits in its online shop. Included ... outfits. , BellasDress has been considered as one ... to the company’s senior spokesman, BellasDress provides superb special ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Growing old was thought ... then. However, in recent studies, it was shown that many of ... credence behind them. As it turns out, the elderly can still ... , Of course, with all the time in the world, older ... them to indulge their passions in the twilight of their lives. ...
Breaking Medicine News(10 mins):Health News:Intercollegiate Contact Athletes with Shoulder Instability Return to In-Season Sports, Study Shows 2Health News:Wild by Nature Opens New Location 2Health News:BellasDress Emerges As Popular Online Supplier Of 2014 Beach Wedding Dresses 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 3
... of a recent study researchers say Lipid-lowering drugs can be ... at a follow-up appointment with a doctor. ,Researchers ... during a hospital stay vs. in an outpatient setting and ... States and Canada were involved in the study, 175 patients ...
... known scientist and accomplished businessman of the U.S. holding ... to set up a high end rapid //diagnostic centre ... be a marketing, selling and research company. ... BioAsia 2004 conference Bangalore on February 28, he said ...
... findings researchers say the risks and benefits of using ... Researchers from Sweden studied more than 3,000 men who ... had their intellectual capacity tested at age 18 years ... for the young men. ,Results of the study ...
... use of hormone replacement therapy among breast cancer survivors has ... rate of recurring or new cancers. ,Swedish researchers embarked ... the disease and therefore subject to the same menopausal symptoms ... 1,300 women over five years. After the initial 345 women ...
... serious consequence of osteoporosis. Such a break can lead to ... ,According to a recent study , it was found ... to be effective in reducing the risk for a vertebral ... the drug can reduce the risk of breaking a bone ...
... reprogram their brains to improve motor skills, say researchers ... ,Functional magnetic resonance imaging and a "cyberglove" record ... redirect motor commands. Stroke or traumatic brain injury results ... until now, scientists were not sure which neurons compensated ...
Cached Medicine News:
(Date:1/15/2014)... As health officials across the Midwest warn against the ... Michigan will offer free diagnostic testing ... pharmacists to administer tests and, in some cases, fill the ... in the study. The Grand Rapids, ...
(Date:1/15/2014)... , Jan. 15, 2014 Massachusetts General Hospital ... AMGN ) announced today that they have ... validate new therapeutic targets and develop novel therapies ... that affects millions worldwide. The MGH-Broad-Amgen collaboration brings ...
(Date:1/15/2014)...  Manufacturers, suppliers and distributors of innovative medical-related products ... most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the Medical ... most litigious industry sectors of cases involving IP ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Intellectual Property Insurance for Medical-related Products and Services 2
... our ability to target experimental cancer treatments ... hand, and more are on the way ... drugs, MILAN, Italy, April 27 , At today,s ... Meeting,of the European Association for the Study of the Liver ...
... Virology Translate Into New Promising Drugs to Combat Hepatitis ... ... Stem Cells of Potential Benefit in Liver ... Liver Diseases, At today,s sessions of the 43rd Annual Meeting of the European,Association ...
Cached Medicine Technology:Molecular Discoveries Shed Light on Liver Cancer -- Hepatocellular Carcinoma (HCC) 2Molecular Discoveries Shed Light on Liver Cancer -- Hepatocellular Carcinoma (HCC) 3Basic Science Discoveries Yield Progress in Hepatology 2Basic Science Discoveries Yield Progress in Hepatology 3Basic Science Discoveries Yield Progress in Hepatology 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: