Navigation Links
Therapy exploits 'addiction' of leukemia cells
Date:4/16/2012

A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules. The research, published by Cell Press online on April 16th in the journal Cancer Cell, identifies non-classical oncogenes critical for tumor development and survival, and describes a potentially less toxic strategy that selectively targets these molecules.

Many cancers are associated with the loss of function of the PTEN tumor suppressor gene, including T-cell acute lymphoblastic leukemia (T-ALL). Loss of PTEN leads to unbridled activation of the PI3K/Akt signaling pathway that drives tumor growth and survival. "We know that there are multiple types of PI3K molecules, designated PI3K, , , or , the unrestricted activities of which could contribute to these processes," explains senior study author, Dr. Thomas Diacovo, from Columbia University Medical Center. "However, what role, if any, distinct PI3K subtypes play in the pathogenesis of T-ALL was unknown."

Using a mouse model of T-ALL, Dr. Diacovo and colleagues found that in the absence of PTEN, the unrestricted activity of either PI3K or PI3K was sufficient to support cancer progression and that deletion of both subtypes was required to impair the development of T-ALL. "We found that these two molecules act as a kind of bottleneck in the progression of T-ALL and that the cancer cells can become addicted to these two specific signaling molecules," says Dr. Diacovo. The researchers went on to show that dual inhibition of both PI3K subtypes was necessary to prolong survival of mice with T-ALL and to promote the death of human tumor cells.

"Our work represents a significant advancement in the understanding of the dynamic interplay that exists between PTEN and specific PI3K subtypes in regulating both normal and abnormal T cell development, as well
'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Immunotherapy for elderly cancer patients finds new promise in drug combination
2. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
3. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
4. KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
5. Long-Term Estrogen Therapy Does Up Breast Cancer Risk: Study
6. Progress toward new chemotherapy agents
7. New genomic test spares patients chemotherapy with no adverse effect on survival
8. Radiotherapy for DCIS still protects against recurrence after 15 years
9. Double whammy: RNAi enhances lung cancer therapy
10. Adrenaline Therapy for Cardiac Arrest Linked to Worse Outcomes
11. Stem Cell Therapy Could Boost Kidney Transplant Success: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... FL- May 05, 2014 (PRWEB) May 06, 2015 ... Grant Lock accepted, on behalf of MEBC, an ... organizations from JDA Software during FOCUS 2015, JDA’s ... attendees across the manufacturing, retail and wholesale distribution ... ensuring that their clients are receiving services that ...
(Date:5/6/2015)... 06, 2015 Baptist Medical Center ... first in north Florida and southeast Georgia region ... latest innovation in total hip replacement surgery performed ... robotic arm that enables the accurate alignment and ... has offered MAKOplasty® partial knee resurfacing using the ...
(Date:5/6/2015)... “ SideChef ” was featured on NewsWatch as part of ... coolest applications on the market for iOS, Android, and Windows. Joe ... review and shared with viewers how this application walks users through ... a good navigator people had to know how to read a ... master navigator. Well what if people could “GPS” their way through ...
(Date:5/6/2015)... Anitha Nallari, MD has joined ... Inc. in Columbus, OH. Dr. Nallari will see patients ... in breast cancer, lung cancer, GI and gallbladder cancer, head ... benign hematology. , Dr. Anitha Nallari is Board ... American Board of Internal Medicine. She completed her medical education ...
(Date:5/6/2015)... California (PRWEB) May 06, 2015 ... hand sanitizers are increasing, driven by the rising consumer ... the spread of contagious diseases. Hand washing is becoming ... of consumer apprehension over contracting infections. Periodic outbreak of ... the recent Ebola virus disease (EVD) epidemic ...
Breaking Medicine News(10 mins):Health News:MEBC Receives Award for Consulting Excellence in Retail 2Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 2Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 3Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 4Health News:An Application to Guide Users through Recipes Was Featured on NewsWatch Television 2Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 2Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 2Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 4
... Blacksburg, Va. Researchers from the Virginia Bioinformatics Institute ... a large family of virulence proteins in oomycete plant ... of their hosts. The protein region contains the amino ... ability to carry the virulence proteins across the membrane ...
... Comparison Tool Gives Anthem Members in Colorado,s metro, ... with Medical Procedures, DENVER, Aug. 4 ... today the launch of its industry-leading transparency,initiative. Now, ... Anthem,Care Comparison, an online tool that provides total ...
... Cancellation of New Medicare Regulation Protects,Texas Seniors, Access ... The Texas Health Care,Association (THCA) today thanked ... E.B. Johnson (D-TX) for helping to lead a,successful, ... Administration,from moving forward with a new regulation that ...
... a rewards club and medication review ... ... operated Sav-Mor Drug Stores has officially introduced the Prescription,Rewards Club, a discount ... Working with their suppliers, Sav-Mor has responded to competitors, $4,generic drug ...
... The methods mothers use to control their children during playtime ... their child,s self-esteem and behavior, according to a new Purdue ... interact with their children based on one study, but what ... for being verbally aggressive have a tendency to try to ...
... Inc. (NYSE: WLP ) today,announced the appointment ... Senior,Business and Consumer Business marketing, effective immediately., ... for leading WellPoint,s,Medicare business division and Consumer Business ... from the unique knowledge of,Medicare and marketing that ...
Cached Medicine News:Health News:Key to virulence protein entry into host cells discovered 2Health News:Anthem Blue Cross and Blue Shield in Colorado Introduces Industry Leading and Comprehensive Transparency Initiative to Colorado 2Health News:Anthem Blue Cross and Blue Shield in Colorado Introduces Industry Leading and Comprehensive Transparency Initiative to Colorado 3Health News:U.S. Representatives Gohmert, Granger, E.B. Johnson Praised by THCA for Helping Lead House Effort to Stop $45.6 Million Texas Medicare Cuts 2Health News:U.S. Representatives Gohmert, Granger, E.B. Johnson Praised by THCA for Helping Lead House Effort to Stop $45.6 Million Texas Medicare Cuts 3Health News:Michigan-based Company Introduces Discount Prescription Drug Program 2Health News:Study: verbal aggression may affect children's behavior 2Health News:WellPoint Appoints Krista A. Bowers as President of Senior Business 2
(Date:5/6/2015)... -- Delcath Systems, Inc. (NASDAQ: DCTH ), a ... with an emphasis on the treatment of primary and ... months ended March 31, 2015.  Highlights ... , Achieved quarterly product revenue of $0.44 million, an ... quarter of 2014; , Activated a prospective patient ...
(Date:5/6/2015)... NEW YORK , May 6, 2015 /PRNewswire/ ... patient activation and patient-reported outcomes for chronic pain, ... report released by The Bravewell Collaborative ... by the Patients Receiving Integrative Medicine Interventions Effectiveness ... medicine. Using data from PRIMIER ...
(Date:5/6/2015)... The Parenteral Drug Association (PDA) Board of ... Richard M. Johnson to continue as President ... pleased to have Richard Johnson continue as ... the Chair of the Board of Directors. "Under Richard,s ... has led a strong staff and dedicated volunteers, hosting ...
Breaking Medicine Technology:Delcath Reports 2015 First Quarter Financial Results 2Delcath Reports 2015 First Quarter Financial Results 3Delcath Reports 2015 First Quarter Financial Results 4Delcath Reports 2015 First Quarter Financial Results 5Delcath Reports 2015 First Quarter Financial Results 6Delcath Reports 2015 First Quarter Financial Results 7Delcath Reports 2015 First Quarter Financial Results 8Integrative Medicine has Positive Impact on Patient Activation, Chronic Pain, Depression 2PDA Extends Richard M. Johnson as President/CEO for Six Additional Years 2
... organizations and individuals across the country and around the ... 1, 2007. Since 1988,World AIDS Day has provided countless ... reinvigorate global, national, regional,and local efforts to stop AIDS., ... Day is leadership. Nearly 27,years since it was first ...
... to Conduct Conference Call on, December 10, 2007 to Discuss ... ... Data, SOUTH SAN FRANCISCO, Calif., Nov. 29 Sunesis,Pharmaceuticals, Inc. ... today announced that it,will present data on the company,s two lead ...
Cached Medicine Technology:AIDS Action Council Statement on World AIDS Day 2007: Leadership Needed for a National Strategy to Stop the AIDS Epidemic 2Sunesis Pharmaceuticals to Present Data on Two Product Candidates at the 49th Annual Meeting of the American Society of Hematology 2Sunesis Pharmaceuticals to Present Data on Two Product Candidates at the 49th Annual Meeting of the American Society of Hematology 3
... (ECP) is a surgical approach to glaucoma ... laser application. The ciliary body (which produces ... from the anterior or posterior segment, through ... tissues are easily and accurately identified utilizing ...
... Centuries of German Craftsmanship have ... in the world. Ocutek® now ... Only holders of the coveted ... eight-year apprenticeship, are qualified to ...
... surgical approach to glaucoma management that employs ... ciliary body (which produces aqueous humour) is ... or posterior segment, through the endoscope in ... and accurately identified utilizing endoscopy. This allows ...
... surgical approach to glaucoma management that employs ... ciliary body (which produces aqueous humour) is ... or posterior segment, through the endoscope in ... and accurately identified utilizing endoscopy. This allows ...
Medicine Products: