Navigation Links
Therapy exploits 'addiction' of leukemia cells
Date:4/16/2012

A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules. The research, published by Cell Press online on April 16th in the journal Cancer Cell, identifies non-classical oncogenes critical for tumor development and survival, and describes a potentially less toxic strategy that selectively targets these molecules.

Many cancers are associated with the loss of function of the PTEN tumor suppressor gene, including T-cell acute lymphoblastic leukemia (T-ALL). Loss of PTEN leads to unbridled activation of the PI3K/Akt signaling pathway that drives tumor growth and survival. "We know that there are multiple types of PI3K molecules, designated PI3K, , , or , the unrestricted activities of which could contribute to these processes," explains senior study author, Dr. Thomas Diacovo, from Columbia University Medical Center. "However, what role, if any, distinct PI3K subtypes play in the pathogenesis of T-ALL was unknown."

Using a mouse model of T-ALL, Dr. Diacovo and colleagues found that in the absence of PTEN, the unrestricted activity of either PI3K or PI3K was sufficient to support cancer progression and that deletion of both subtypes was required to impair the development of T-ALL. "We found that these two molecules act as a kind of bottleneck in the progression of T-ALL and that the cancer cells can become addicted to these two specific signaling molecules," says Dr. Diacovo. The researchers went on to show that dual inhibition of both PI3K subtypes was necessary to prolong survival of mice with T-ALL and to promote the death of human tumor cells.

"Our work represents a significant advancement in the understanding of the dynamic interplay that exists between PTEN and specific PI3K subtypes in regulating both normal and abnormal T cell development, as well as in sustaining tumor proliferation and survival," concludes Dr. Diacovo. "By pinpointing these therapeutic targets, it may be possible to limit the toxicity that is associated with current T-ALL therapies and to avoid the potential global impact that less selective inhibition of the PI3K/Akt signaling pathway may have on cancer patients."


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Immunotherapy for elderly cancer patients finds new promise in drug combination
2. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
3. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
4. KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
5. Long-Term Estrogen Therapy Does Up Breast Cancer Risk: Study
6. Progress toward new chemotherapy agents
7. New genomic test spares patients chemotherapy with no adverse effect on survival
8. Radiotherapy for DCIS still protects against recurrence after 15 years
9. Double whammy: RNAi enhances lung cancer therapy
10. Adrenaline Therapy for Cardiac Arrest Linked to Worse Outcomes
11. Stem Cell Therapy Could Boost Kidney Transplant Success: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2019)... ... December 06, 2019 , ... Allegheny Health Network (AHN) has named ... joined AHN from WVU Medicine in May 2018, previously served as AHN’s Vice Chair ... interim chair since October and is also part of the pathology faculty at Drexel ...
(Date:12/6/2019)... ... December 06, 2019 , ... Dr. Scott Howell, a 2019 graduate of Trident ... the health benefits of coconut oil in the 7 November 2019 edition of ... Cardiometabolic Profile: A Structured Literature Review,” led by Dr. Hector O. Santos, examines the ...
(Date:12/5/2019)... ... December 05, 2019 , ... ... ranging from launching exceptional products that help people embrace, achieve, and maintain a ... “We’ve never been more committed to our mission of impacting world health, so ...
(Date:12/4/2019)... ... December 04, 2019 , ... Healthcare Real ... the only national awards dedicated to recognizing excellence in the areas of healthcare ... presented in nine different categories during the GlobeSt Healthcare Conference today in Scottsdale, ...
(Date:12/2/2019)... ... December 02, 2019 , ... TrialScope, the global leader ... the North American branch of the healthcare business of Merck KGaA, Darmstadt, Germany, ... educate and inform patients, caregivers, the public, patient advocacy groups and healthcare professionals ...
Breaking Medicine News(10 mins):
(Date:12/6/2019)... ... December 06, 2019 , ... ... of treatments for psychiatric and neurodegenerative disorders, announced today that the U.S. Food ... NBTX-001 Inhaler, allowing the Company to initiate its Phase 2b trial for the ...
(Date:12/5/2019)... ... December 05, 2019 , ... ... entrance into the Amazon Web Services (AWS) Public Sector Partner Program; a ... Public Sector Partner program recognizes and collaborates with partners that offer solutions ...
(Date:12/4/2019)... ... December 04, 2019 , ... Tenex ... minimally invasive technologies to treat chronic pain in soft and hard tissue, recently ... TX® technology. , Dr. Bernard Morrey, Chief Medical Officer of Tenex ...
Breaking Medicine Technology: