Navigation Links
Therapy exploits 'addiction' of leukemia cells
Date:4/16/2012

A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules. The research, published by Cell Press online on April 16th in the journal Cancer Cell, identifies non-classical oncogenes critical for tumor development and survival, and describes a potentially less toxic strategy that selectively targets these molecules.

Many cancers are associated with the loss of function of the PTEN tumor suppressor gene, including T-cell acute lymphoblastic leukemia (T-ALL). Loss of PTEN leads to unbridled activation of the PI3K/Akt signaling pathway that drives tumor growth and survival. "We know that there are multiple types of PI3K molecules, designated PI3K, , , or , the unrestricted activities of which could contribute to these processes," explains senior study author, Dr. Thomas Diacovo, from Columbia University Medical Center. "However, what role, if any, distinct PI3K subtypes play in the pathogenesis of T-ALL was unknown."

Using a mouse model of T-ALL, Dr. Diacovo and colleagues found that in the absence of PTEN, the unrestricted activity of either PI3K or PI3K was sufficient to support cancer progression and that deletion of both subtypes was required to impair the development of T-ALL. "We found that these two molecules act as a kind of bottleneck in the progression of T-ALL and that the cancer cells can become addicted to these two specific signaling molecules," says Dr. Diacovo. The researchers went on to show that dual inhibition of both PI3K subtypes was necessary to prolong survival of mice with T-ALL and to promote the death of human tumor cells.

"Our work represents a significant advancement in the understanding of the dynamic interplay that exists between PTEN and specific PI3K subtypes in regulating both normal and abnormal T cell development, as well as in sustaining tumor proliferation and survival," concludes Dr. Diacovo. "By pinpointing these therapeutic targets, it may be possible to limit the toxicity that is associated with current T-ALL therapies and to avoid the potential global impact that less selective inhibition of the PI3K/Akt signaling pathway may have on cancer patients."


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Immunotherapy for elderly cancer patients finds new promise in drug combination
2. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
3. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
4. KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
5. Long-Term Estrogen Therapy Does Up Breast Cancer Risk: Study
6. Progress toward new chemotherapy agents
7. New genomic test spares patients chemotherapy with no adverse effect on survival
8. Radiotherapy for DCIS still protects against recurrence after 15 years
9. Double whammy: RNAi enhances lung cancer therapy
10. Adrenaline Therapy for Cardiac Arrest Linked to Worse Outcomes
11. Stem Cell Therapy Could Boost Kidney Transplant Success: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... The iaedp Foundation, the premier provider ... caring for those suffering from the full spectrum of disordered eating, announced today that ... professionals from nearly all 50 states and several countries converged on the Green Valley ...
(Date:3/24/2017)... ... March 24, 2017 , ... As the ... create a communications platform that positions them as the go-to thought leader in ... their online publication as an always-on, always-fresh news, views and advocacy engine, called ...
(Date:3/24/2017)... ... March 24, 2017 , ... Viewers who like to educate themselves ... facts, cultural practices, goods, services, and societal issues tend to appreciate and love the ... popular practice of utilizing running events for causes around the world. , ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... with God #TruthwithGrace”: a devotional journal chronicling the writer’s path toward true communion ... to Walk with God #TruthwithGrace” is the creation of published author Lea Michelle ...
(Date:3/24/2017)... ... , ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a ... to the fullest, as God intended. “The Adventures of Joey, The Dog Who Barks ... pursuing her passion for writing, especially about truth and human behavior. , Published by ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to ... global medical cannabis market will reach a value of USD 55.8 billion ... for the new growing industry. By the end of 2016, 28 states ... medical cannabis. More conservative states like Arkansas and ...
(Date:3/24/2017)... Today Stock-Callers.com have issued research reports ... Inc. (NASDAQ: NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences Corp. ... ). These companies are part of the Healthcare sector, which ... 23 rd , 2017, with the NYSE Health Care Index ... companies in the S&P 500 were down about 0.4% as ...
(Date:3/24/2017)... 23, 2017  Mirabilis Medical, a ... for non-invasive surgery, announced today CE Mark authorization ... of uterine fibroids throughout the European Union.  The ... from the US Food and Drug Administration to ... in the United States.  The Mirabilis System combines ...
Breaking Medicine Technology: