Navigation Links
Therapeutic vaccines
Date:11/3/2008

This release is available in German.

SARS, avian flu, Ebola outbreaks of deadly viral infections are becoming increasingly frequent. And we still don't have vaccines for many of the pathogens responsible. One of the most dangerous classes of viral diseases is the zoonosis, which can be transmitted from animals to humans with sometimes fatal consequences. One of these is caused by the West Nile virus (WNV), which was first identified in Uganda in 1937. The virus was carried to the United States in 1999 and had spread through the whole of North America within five years. There is now a risk that it will propagate worldwide. Since its first appearance in the United States, around 400 people have died there after coming into contact with the West Nile virus. A new vaccine promises to provide protection.

Scientists at the Fraunhofer Institute for Cell Therapy and Immunology IZI in Leipzig have developed the DNA vaccine. "In this type of vaccine, DNA molecules known as plasmids extracted from the pathogen are used for inoculation, instead of the whole virus. They contain the genetic code for the antigens that stimulate the body to produce antibodies. We can thus replicate the virus's natural infection route without actually triggering the disease," explains Dr. Matthias Giese, the IZI's head of vaccine development. Conventional methods of vaccination involve injecting a dead or weakened form of the pathogen into the patient's body, which responds by producing the corresponding antibodies and developing immunity to the disease. An alternative is to inject a serum that already contains these antibodies. Such vaccines are merely preventive. By contrast with live vaccines, which carry a risk of provoking the disease, DNA vaccines are absolutely biologically safe. Moreover, they activate all existing defense mechanisms in the body, are cheap to produce and can be stored without a refrigerator which makes them ideal for use in subtropical and tropical climates.

"Since the human immune system is very similar to that of other mammals, we are developing a cross-species vaccine for use in both veterinary and human medicine. And unlike conventional vaccines, DNA vaccines can be used both as prophylactics and as therapeutics, i.e. in cases where the disease is already present," says Dr. Matthias Giese, citing the further benefits. The WNV vaccine has already passed initial tests. Giese expects the laboratory research to be completed by the end of 2009. After that, another 3 years or so will be needed for the approval procedure including clinical trials. Then, it is hoped, the world's first therapeutic WNV vaccine will be ready for market.


'/>"/>

Contact: Dr. Matthias Giese
matthias.giese@izi.fraunhofer.de
49-341-355-362-105
Fraunhofer-Gesellschaft
Source:Eurekalert

Related medicine news :

1. AUDIO from Medialink and Commit Lozenge: Wanna Quit Smoking With Therapeutic Nicotine? Just Follow the Directions
2. Prime Therapeutics Receives TIPPS Certification
3. Adams Respiratory Therapeutics to Celebrate 10th Anniversary of its Incorporation on September 12
4. Transition Therapeutics Announces Fiscal 2007 Year End Financial Results
5. Lorus Therapeutics announces election of three new Directors and appoints a new Chairman
6. Deane F. Johnson Center for Neurotherapeutics to Launch First Mobile Medical Unit on October 4th
7. Russell Investment Group Advises Protalix Biotherapeutics of Index Adjustment
8. Adams Respiratory Therapeutics Announces FDA Approval of Grape-Flavored Delsym(R)
9. Prime Therapeutics Announces URAC Accreditation
10. Cell Therapeutics, Inc. (CTI) to Present at BIO Investor Forum
11. Horizon Therapeutics, Inc. Scheduled to Present at Upcoming BioPartnering Europe Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance ... care insurance companies have a waiver for care if the client has a cognitive ... the family pays for care, is often waived, so the benefits from their insurance ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized ... have expanded their existing home health joint venture through an agreement, effective October ... a joint venture home health company with Asante, delivering clinically integrated care, for ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
Breaking Medicine Technology: