Navigation Links
Therapeutic melanoma vaccine improves response rate, progression-free survival
Date:6/2/2011

HOUSTON ― A vaccine for one of the most lethal cancers, advanced melanoma, has improved response rate and progression-free survival for patients when combined with the immunotherapy drug Interleukin-2, according to research led by scientists from The University of Texas MD Anderson Cancer Center and Indiana University Health Goshen Center for Cancer Care.

The findings, published in the June 2 New England Journal of Medicine, mark the first vaccine study in the disease and one of the first in cancer overall to show clinical benefit in a randomized Phase III clinical trial. It's also the first cancer vaccine to show an improved response rate in patients.

The research was first presented on the plenary session of 2009 American Society of Clinical Oncology.

According to the American Cancer Society, melanoma has one of the fastest growing incidence rates of all cancers. In 2010, more than 68,130 people in the U.S. were diagnosed with melanoma and 8,700 died from the disease. The five-year survival rates for those with regional and metastatic disease are 65 percent and 16 percent, respectively.

"Obviously, this is a disease, in its advanced setting, in need of better therapies for patients," said Patrick Hwu, M.D., professor and Chair of the Department of Melanoma Medical Oncology and the study's senior author. "This study serves as a proof-of-principle for the role of vaccines in melanoma and in cancer therapy overall. If we can use the body's own defense system to attack tumor cells, we provide a mechanism for ridding the body of cancer without destroying healthy tissue."

During their tenure at the National Cancer Institute NCI), Hwu and Douglas Schwartzentruber, M.D., the medical director of the Goshen Center for Cancer Care, were involved in the vaccine's development and early basic and clinical studies. The peptide vaccine, known as gp100:209-217 (200M), works by stimulating patients' T cells, kno
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Heart drug cuts prostate cancer risk; holds potential for therapeutic use
2. New therapeutic target for lung cancer
3. McCain gives $5 million to St. Michael’s Hospital for therapeutic endoscopy
4. Researchers discover possible biomarker and therapeutic target for melanoma
5. Study identifies therapeutic target for liver cancer and predictive biomarker of response
6. Therapeutic lifestyle changes as useful as drugs in improving mental health
7. Mayo Clinic researchers confirm value of therapeutic hypothermia after cardiac arrest
8. Study compares balanced propofol sedation with conventional sedation for therapeutic GI endoscopic procedures
9. Save messengers -- modified mRNAs open up new therapeutic possibilities
10. Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
11. Optimizing patient outcomes after therapeutic hypothermia for traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 17, 2015 Enthusiasts of gourmet cuisine and ... April 25, 2015. The event will be held in the ... (201 Monroe Ave NW, Grand Rapids, MI 49503) and will ... Michigan area. Patrons are encouraged to savor the food and ... , This year’s event will feature seven chefs, including:, ...
(Date:4/17/2015)... At the end of February 2015, ... “Salute to the Oscars” in the Stardust Penthouse on ... the impressive Los Angeles skyline. These events honoring the ... LA’s leading producer of sustainable product placement in TV ... premier providers of eco-friendly and socially conscious products and ...
(Date:4/17/2015)... York (PRWEB) April 17, 2015 ... allege this class of prescription medications increases the ... attack, stroke or other life-threatening cardiovascular event continue ... U.S. District Court, Northern District of Illinois. According ... U.S. Judicial Panel on Multidistrict Litigation (JPML) on ...
(Date:4/17/2015)... La Farge, WI (PRWEB) April 17, 2015 ... farmers, will participate in the United Nations’ International Year ... From April 19-25, Organic Valley farmer-owners and employees will ... coast, learning from experts along the way about the ... , Hailing from as far as Maine, Wisconsin, ...
(Date:4/17/2015)... 17, 2015 The American College of Traditional Chinese ... Application Day on April 29. The event will be held from ... at 555 DeHaro St. in San Francisco, CA. , The agenda ... in at the DeHaro campus (room F), 11:10 a.m. – ... Noon – Light lunch with current students, faculty and staff, 1 ...
Breaking Medicine News(10 mins):Health News:Children’s Leukemia Foundation of Michigan Presents 3rd Annual CRUSH Grand Rapids 2Health News:Choices Recovery Speaks with Dakota Hood of “The Hunger Games” about Addiction in Hollywood 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4Health News:Organic Valley Farmers and Employees "Cycling for Sustainability" Through 215 Miles of California Watershed April 19-25 2Health News:Organic Valley Farmers and Employees "Cycling for Sustainability" Through 215 Miles of California Watershed April 19-25 3Health News:American College of Traditional Chinese Medicine Hosts Open House 2
... Mass. -- In the fall of 1917, a new strain ... a typical flu epidemic: Most deaths occurred among the elderly, ... 1918, a deadlier version of the same virus began spreading, ... 50 million people about 3 percent of the world,s ...
... , WEDNESDAY, March 9 (HealthDay News) -- A ... new ways to treat pain and disease in humans, scientists ... ion channels, which control the flow of ions across cell ... biological processes and diseases. In their research on the ...
... What difference does it make if homo sapiens lost ... turns out. Losing a few snippets of DNA may explain ... mammals. It may also be the reason that male penises are ... and mice. It appears that a genetic trait for a ...
... of a common etiquetteholding a door for someonesuggests that courtesy ... reduce the work for those involved. The research, by Joseph ... is the first to combine two fields of study ordinarily ... published in a forthcoming issue of Psychological Science , ...
... clear and watery substance that bathes the brain and ... previously realized. Howard Hughes Medical Institute investigator Christopher ... Zappaterra, and their colleagues have discovered that cerebrospinal fluid ... dramatically with age. In the lab, CSF by itself ...
... News) -- Certain types of medical errors are 46 ... than bottom-ranked hospitals, according to a new study. ... 2007 to 2009 and focused on 13 patient safety ... foreign objects left in the body after procedures and ...
Cached Medicine News:Health News:MIT scientists identify new H1N1 mutation that could allow virus to spread more easily 2Health News:MIT scientists identify new H1N1 mutation that could allow virus to spread more easily 3Health News:Lost DNA May Have Made Us More Human 2Health News:More reasons to be nice: It's less work for everyone 2Health News:Cerebral spinal fluid guides stem cell development in the brain 2Health News:Cerebral spinal fluid guides stem cell development in the brain 3Health News:Hospital Safety Varies Widely Nationwide: Report 2
(Date:4/17/2015)... ASSESS shows   plasma circulating ... viable alternative to tumour biopsy   IGNITE ... advanced NSCLC   AstraZeneca today presented results from ... DNA (ctDNA) testing for epidermal growth factor receptor (EGFR) mutation ... cancer (NSCLC) in clinical practice. [ 1 ] ...
(Date:4/17/2015)... April 17, 2015  Over the next five years, the ... grow, with ArcView predicting that 14 more states will legalize ... The U.S. market for legal cannabis grew 74 percent in ... Analysts project the market could grow more than fourfold to ... soften their stance on marijuana. Cannabiz Mobile Inc. ...
(Date:4/17/2015)... Apr. 16, 2015 Research and Markets ... of the "The Corporate Reputation of Pharma ... Edition " report to their offering. ... Perspective, is now in its fourth edition. This ... early 2015). For each annual Corporate Reputation report, ...
Breaking Medicine Technology:"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 2"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 3"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 4Cannabiz Mobile Analyst Brief: Next Big Thing by Torus IR Issued by BrokerBank Securities, Inc. 2The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2
... WIRE)--May 30, 2007 - INNOVIVE Pharmaceuticals,Inc. (OTCBB: ... a Phase I,trial of INNO-406, an orally ... or,treatment-intolerant chronic myelogenous leukemia, will be,presented at ... Annual,Meeting. The meeting takes place June 1- ...
... from various,clinical studies including a pivotal Phase III trial ... Nexavar (sorafenib) tablets will be presented at the Annual,Meeting ... USA from June 1 - 5, 2007. , On ... be held on June 4, 2007. Starting at around ...
Cached Medicine Technology:Innovive Pharmaceuticals to Present Interim Data from Phase I Study,of INNO-406 at the American Society of Clinical Oncology Annual,Meeting 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: