Navigation Links
Therapeutic cloning treats Parkinson's disease in mice
Date:3/23/2008

NEW YORK, March 23, 2008Research led by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC) has shown that therapeutic cloning, also known as somatic-cell nuclear transfer (SCNT), can be used to treat Parkinsons disease in mice. The studys results are published in the March 23 online edition of the journal Nature Medicine.

For the first time, researchers showed that therapeutic cloning or SCNT has been successfully used to treat disease in the same subjects from whom the initial cells were derived. While this current work is in animals, it could have future implications as this method may be an effective way to reduce transplant rejection and enhance recovery in other diseases and in other organ systems.

In therapeutic cloning or SCNT, the nucleus of a somatic cell from a donor subject is inserted into an egg from which the nucleus has been removed. This cell then develops into a blastocyst from which embryonic stem cells can be harvested and differentiated for therapeutic purposes. As the genetic information in the resulting stem cells comes from the donor subject, therapeutic cloning or SCNT would yield subject-specific cells that are spared by the immune system after transplantation.

The new study shows that therapeutic cloning can treat Parkinsons disease in a mouse model. The scientists used skin cells from the tail of the animal to generate customized or autologous dopamine neuronsthe missing neurons in Parkinsons disease. The mice that received neurons derived from individually matched stem cell lines exhibited neurological improvement. But when these neurons were grafted into mice that did not genetically match the transplanted cells, the cells did not survive well and the mice did not recover.


'/>"/>

Contact: Jeanne D'Agostino
dagostij@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Vista Partners Initiates Coverage on Arana Therapeutics (ASX: AAH; AIM: AAHx)
2. Transition Therapeutics to Present at Cowen & Company 28th Annual Healthcare Conference
3. Juvaris BioTherapeutics, Inc. Announces the Appointment of Grant E. Pickering as Chief Executive Officer
4. Echo Therapeutics Announces Positive Results from Symphony(TM) Transdermal Continuous Glucose Monitoring System Study at Tufts Medical Center
5. Cell Therapeutics, Inc. (CTI) Reports Recent Accomplishments and 2007 Fourth Quarter and Year End Financial Results
6. Oracle Healthcare Acquisition Corp. and Precision Therapeutics, Inc. Mutually Terminate Merger Agreement; Oracle Healthcare Acquisition Corp. Cancels Special Meeting
7. Bayer HealthCare and Juvaris BioTherapeutics Announce Major Licensing Agreement
8. Cell Therapeutics, Inc. Announces Issuance of $51.7 Million of New 2012 Convertible Senior Notes
9. Jeffrey Modell Foundation and Talecris Biotherapeutics Expand Diagnostic Services for Primary Immunodeficiencies at Lucile Packard Childrens Hospital at Stanford
10. Nanomedicine system engineered to enhance therapeutic effects of injectable drugs
11. Sirion Therapeutics Receives NDA Acceptance and Priority Review From the FDA for Durezol(TM) in the Treatment of Postoperative Ocular Inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... Presence Technology ... has been included by Gartner, Inc. in the Contact Center Infrastructure Magic Quadrant ... Center Infrastructure technologies, some of which include: Computer-telephony integration (CTI)/Web services interfaces, ...
(Date:5/31/2016)... ... 31, 2016 , ... St. Joseph Medical Center (SJMC) announced ... which enables physicians at SJMC’s two hospital campuses, downtown and in the Heights, ... the exchange. SJMC’s membership in the health information exchange underscores the hospital’s commitment ...
(Date:5/31/2016)... ... May 31, 2016 , ... The University of Tennessee Medical ... and the latest in Clinical Patient Pod (CPP) technologies provided through ... directly into the clinical workflow. These insights are empowering the more than 30 ...
(Date:5/31/2016)... ... 2016 , ... DDL, Inc. announced today it has expanded the scope of ... ISO 594-1 and ISO 594-2 testing for conical (Luer) fittings. , A conical ... medical devices (e.g. a syringe and hypodermic needle) that carry small volumes of fluids. ...
(Date:5/31/2016)... ... May 31, 2016 , ... Spartan Bioscience today introduced the ... and convenience. , The Cube is exceptionally small—it takes up the space of ... easily into any space, whether in a hospital, doctor’s office, or pharmacy. , ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... 31, 2016 According to a ... (Scanners, Software), by Type (Human, Animal Pathology), by End ... Drug Discovery) - Global Forecasts to 2021", published by ... forecast period of 2016 to 2021. This market is ... USD 384.3 Million in 2016, at a CAGR of ...
(Date:5/31/2016)... 2016   Plexus Technology Group, LLC ... management systems (AIMS), is pleased to announce the ... President of Technology. In this new capacity, Mr. ... the company,s technological development. He will collaborate with ... the expansion of new products, product features and ...
(Date:5/31/2016)... BASEL, Switzerland , May 31, 2016 ... has announced the initiation of a first-in-human clinical trial ... class, fusion molecule - S101 is currently being developed ... phase 1 study is designed to evaluate the safety ... be conducted at several sites across the ...
Breaking Medicine Technology: