Navigation Links
Theory of single stem cell for blood components challenged
Date:3/4/2010

HOUSTON -- (March 5, 2010) Components of the blood or hematopoietic system derive from stem cell subtypes rather than one single stem cell that gives rise to all the different kinds of blood cells equally, said scientists from Baylor College of Medicine (www.bcm.edu) in a report that appears in the current issue of the journal Cell Stem Cell (www.cell.com/cell-stem-cell/)

"While previous reports in journals have hinted at the possibility of stem cell subtypes, this study represents the clearest data to show that is true," said Dr. Margaret Goodell, director of the Stem Cells and Regenerative Medicine (STaR) Center (www.bcm.edu/star/) at BCM. "From a scientific point of view, it's making us re-evaluate the view of the stem cells that come from adults. It challenges the dogma that there is one type of stem cell."

She and the report's first author, Dr. Grant A. Challen, a postdoctoral associate in the Center for Cell and Gene Therapy (www.bcm.edu/genetherapy/) at BCM, said that the stem cell subtypes they identified meet the strictest criteria.

To accomplish this, Challen, Goodell and their colleagues used a special dye technique to discriminate the different hematopoietic stem cell subtypes myeloid, which have a preference for giving rise to red blood cells, macrophages (non-specific immune cells that engulf foreign bodies) and similar cells; and lymphoid, which similarly preferentially give rise to the body's immune system cells.

By transplanting single stem cells into individual mice, Challen was able to confirm that these subtypes exist and act as the researchers had thought. The subtypes also maintain a stable population of the stem cells over time, another characteristic of these progenitor cells.

"We cannot rule out that there is a single progenitor cell to both sub-types," said Goodell. "We don't know where to look for it. Maybe it does not exist or maybe it exists only when the bone marrow begins to be made but does not persist into adulthood."

The finding has implications for treatment.

"People have been looking for purer and purer stem cell types," Goodell said. "In doing that, they may not be getting all the stem cell types they need. Maybe in the clinic, it is better to have less pure types."

"You may need a spectrum of stem cells to create a complete blood system," said Challen.

In bone marrow or peripheral blood stem cell transplants for cancers or blood disorders, doctors often wipe out a patient's own bone marrow and replace it with stem cells that can repopulate the bone marrow. Scientists are constantly improving that system.

As animals age, their proportions of stem cell subtypes change, Challen said. "The myeloid cells have a slower rate of baseline turnover and a higher rate of self renewal. They persist over time, such that the myeloid-biased stem cells become more prevalent with time. This may have implications for how different types of cancers become more prevalent with age."

The two types react differently to the presence of transforming growth factor beta, Challen said. One type increases and the other decreases.

Challen said it is also important to remember the big question."Does this translate to humans as well? Some markers may be different, but I think it will."

Goodell holds the Vivian Smith Chair of Regenerative Medicine at BCM.


'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related medicine news :

1. Study Puts 1 Alzheimers Theory in Doubt
2. Discovery supports theory of Alzheimers disease as form of diabetes
3. Carnegie Mellon neuroscientist proposes new theory of brain flexibility
4. Controversial theory of Alzheimers origin funded
5. Cancer theory stands the test of time -- rediscovering Boveri a century later
6. Freshman 15 Theory Takes a Pounding
7. Study supports theory that rise in autism is related to changes in diagnosis
8. Parents stricter with older kids to set example: game theory study
9. Theory of How Brain Builds Images Earns Grawemeyer Prize
10. Mexico Presents Flawed Theory in Shooting Death of American Journalist
11. Einstein scientists propose new theory of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... June 28, 2017 , ... American Farmer proudly announces the participation of Pure ... television series, scheduled to broadcast fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET ... of garden pea seed. As demand grew, the small company located in Moscow, Idaho ...
(Date:6/28/2017)... ... June 28, 2017 , ... ... financial consultations to communities in northern Virginia and DC, is announcing a cooperative ... for patients with Alzheimer’s and other disorders that lead to memory impairment. , ...
(Date:6/27/2017)... ... , ... Harbour , a DAO (decentralized autonomous organization) that harnesses the ... their technical specifications . , 2017 has seen an explosion of token launches ... which offerings will garner the greatest ROI. Dean Eigenmann, Co-founder and CEO of Harbour, ...
(Date:6/27/2017)... ... , ... A January 18th article on medGadget reports that the ... the year 2024 according to a new report. The article also notes that the ... Los Angeles area clinic Beverly Hills Periodontics & Dental Implant Center says that it ...
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... ... P. Fabrykiewicz Scholarship Foundation Fundraiser hygiene symposium in Mystic, CT. Covering the process ... Urbanski offered their experience in these popular periodontal procedures. Drs. Toback and Urbanski ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)...  ivWatch LLC, a medical device company focused on ... is pleased to announce it was the Bronze Winner ... and Equipment at the 2017 Medical Design Excellence Awards ... The award was presented by Medical Device and Diagnostics ... New York during MD&M East, ...
(Date:6/12/2017)... , June 12, 2017 Kineta, Inc., a ... announced Kineta Vice President of R&D and Head ... the Pandemic Preparedness for the Northwest and Beyond ... held on June 14, 2017 from 8:30-10:30 AM PDT at ... Dr. Bedard will be joined by ...
(Date:6/9/2017)... and INDIANAPOLIS , June 9, ... living with diabetes. In a further effort to help ... affected by this condition, the International Diabetes Federation (IDF) ... ) have come together for the second phase of ... Systems programme (BRIDGES 2), reaffirming their commitment to helping ...
Breaking Medicine Technology: