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Their immune cells, fighting your cancer
Date:9/19/2007

tant to cancer (Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.0602382103).

Cui hopes to begin human trials next summer in the US, when the immune systems of potential granulocyte donors will be at their peak.

The concept of using immune cells from one person to fight cancer in another person is a very hot topic right now, says John Gribben, a cancer immunologist at Cancer Research UKs experimental medicine centre at St Bartholomews Hospital, London.

However, if Cui plans to try this therapy in people, he will have to be very careful, Gribben says. If theyre using live cells there is a theoretical risk of graft-versus-host disease, which can prove fatal. This is a particular problem in patients with depleted immune systems, where transfused cells may proliferate and take over the hosts immune system, eventually destroying cells in the bone marrow. Cui says he is working with the FDA to minimise this risk.


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Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-207-611-1210
New Scientist
Source:Eurekalert

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