Navigation Links
The zebrafish revealed a central regulator for the development of the brain histamine system
Date:2/5/2013

Research has shown that mutations in the psen1 gene are common in the familial forms of Alzheimer's disease, and the Presenilin-1 protein that the gene encodes is known to be involved in the cleavage of the amyloid precursor protein. In Alzheimer's disease the amyloid precursor protein is not cleaved the normal way, and the protein accumulates in the brain damaging neuronal tracts and neurons. It is still unknown if the psen1 gene is involved in the etiology of Alzheimer's disease via another mechanism.

Professor Pertti Panula's research team at the University of Helsinki has elucidated the role of psen1 gene in the development of the neuronal histamine system and its modulation. Histamine is one of the neurotransmitters, which all are essential for cognitive functions, which in turn are impaired in Alzheimer's disease. The histamine system is altered during the progression of Alzheimer's disease.

In the study the zebrafish was used as a model organism. The rapidly developing zebrafish is suitable as a model organism, as its transparency allows researchers to study the development and function of vital organs. To study the function of psen1 gene, zebrafish that did not produce functional Presenilin-1 protein were generated. Despite the fact that the fish lacked functional Presenilin-1 they were viable and developed until adulthood.

The lack of Presenilin-1 protein induced a change in the behavior of the larval zebrafish, they did not as normal fish react to fast changes in the light intensity. "Based on previous research we know that this change in behavior is associated with lack of histamine in the brain", Panula explains.

In adulthood the motor behavior of the mutant zebrafish differed from the normal fish: the fish swam by the edges of the arena that was available and avoided the inner part. Previous studies from the group have shown that this behavioral alteration also is due to changes in the histamine system.

<
'/>"/>
Contact: Pertti Panula
pertti.panula@helsinki.fi
358-405-922-323
University of Helsinki
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
2. Zebrafish reveal promising mechanism for healing spinal cord injury
3. Tension on gut muscles induces cell invasion in zebrafish intestine, mimicking cancer metastasis
4. Individual gene differences can be tested in zebrafish
5. Weirdest hCG Questions Revealed
6. Green Tea Weight Loss Results and Health Benefits Revealed
7. Secrets of lung cancer drug resistance revealed at UCSF
8. Better treatment for brain cancer revealed by new molecular insights
9. More Benefits of Breast Milk Revealed
10. Lack of support for ring-fencing cancer drugs fund revealed
11. Secret of Anesthesia Revealed, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... proliferation of endogenous neural precursor cells cannot alone ... From the perspective of neural plasticity, Dr. Yun ... China observed the effects of functional electrical stimulation ... expression of basic fibroblast growth factor and epidermal ... infarct side. The researchers found that functional electrical ...
(Date:4/22/2014)... the New Jersey Institute of Technology (NJIT) today ... the launch of the New Jersey Innovation Institute ... model for business innovation through the leveraging of ... U.S. Senator Cory Booker, Panasonic Corp. of North ... Lieutenant Governor Kim Guadagno, New Jersey Secretary of ...
(Date:4/22/2014)... primary care for low-income patients may ease the ... while improving patient health, researchers have concluded. , ... clinics that avoid costs associated with insurance administration ... admission rates and emergency room visits, according to ... , The researchers estimated that the major ...
(Date:4/22/2014)... risk of pregnancy among women using a newer method ... 10 times greater over a 10-year period than using ... researchers at Yale University and UC Davis has found. ... Contraception , the study found the higher risk ... the brand name Essure. , "This study provides ...
(Date:4/22/2014)... Johns Hopkins scientists have found a way to block ... development of atherosclerosis, the main cause of heart attacks ... humans. The condition develops when fat builds inside blood ... hardened, greatly reducing their ability to feed oxygen-rich blood ... a series of experiments, described April 7 in the ...
Breaking Medicine News(10 mins):Health News:Government and industry leaders herald launch of NJIT's New Jersey Innovation Institute 2Health News:Clinics not bogged down by red tape can ease health cost burdens 2Health News:Risk of pregnancy greater with newer method of female sterilization 2Health News:Risk of pregnancy greater with newer method of female sterilization 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 2Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 4
... influenza testing is associated with reductions in the use ... ,The study was posted online today that ... of Archives of Internal Medicine, one of the JAMA/Archives ... speed at which influenza and other viral diseases are ...
... stress and depression,// may be associated with higher ... in turn are related to an increased risk for ... 22 issue of Archives of Internal Medicine, one of ... studies have linked psychosocial characteristics with cardiovascular disease and ...
... Union after a break of six months. Officials from Hungary ... holding of 3000 geese, and the death of 40 geese. The ... has been confirmed as the deadly H5N1 strain, samples are being ... measures are on to control the spread. A protection zone of ...
... Is the everyday talk of HIV/AIDS falling on deaf ears? ‘Careless’ ... today,// who appear to be completely in-charge of their lives, yet ... ,A new survey has shown that, nearly three out of ... getting HIV. , ,The Body Shop and MTV got ...
... history of abuse by intimate partners have significantly higher ... history of such abuse, according to a study conducted ... ,The higher costs and utilization continued long after the ... University of Washington (UW), and the Harborview Injury Prevention ...
... is how some passengers describe it.// , ... who were infected with a stomach flu-causing bug; norovirus aboard ... , This virus causes a contagious gastric illness, gastroenteritis that ... , The liner’s owner Cunard Line notified ...
Cached Medicine News:Health News:Rapid Flu Testing Decreases Antibiotic Use in Hospitalized Adults 2Health News:Psychosocial Factors Associated With Higher Levels of Inflammatory Markers 2Health News:Fowl Fall in Hungary-Bird Flu Strikes 2Health News:Health Care Costs - Significant for Abused Women 2
(Date:1/15/2014)... Most osteoporosis patients want a choice in the medication ... by Mission Pharmacal Company. The survey, conducted by ... community, revealed that 74 percent of osteoporosis patients surveyed ... other than a pill or a tablet. ...
(Date:1/15/2014)... 15, 2014 AARP Foundation today announced it has established ... from the severe cold weather that has gripped much of ... those in need; so to support these emergency relief efforts ... $250,000, which could mean up to $500,000 in aid. The ...
(Date:1/15/2014)... THOUSAND OAKS, Calif. , Jan. 15, 2014 ... and Amgen (NASDAQ: AMGN ) announced ... to jointly discover and validate new therapeutic targets ... (IBD), a chronic disorder that affects millions worldwide. ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... Healthcare and,Laboratory Corporation of America(R) Holdings (LabCorp(R)) ... agreement to discuss future,possibilities to co-develop new ... diagnostics, metabolic syndrome, oncology and diabetes. Under ... new tests that,could make the biggest impact ...
... of the American Pain Society ... ... sustained pain relief from diabetic neuropathic pain (DNP),compared to placebo-treated patients, according ... (APS) in Tampa, Fla., "This is the first placebo-controlled trial of ...
Cached Medicine Technology:Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 2Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 3Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 4New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 2New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 3New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 4
Codman Hakim Programmable micro offers the ability to optimize the opening pressure of a shunt system before and after implantation. A shunted patient's condition will often change over the course of...
Codman Hakim Programmable valve cylindrical with PrechamberInline offers the ability to optimize the opening pressure of a shunt system before and after implantation. A shunted patient's condition wi...
... V is a low viscosity bone cement, ... vertebroplasty. The bone cement is injected into ... Osteopal V is used for the augmentation ... zirconium dioxide is included in the cement ...
Leadpoint Micro-Electrode Recording...
Medicine Products: