Navigation Links
The structure of resistance
Date:2/22/2008

A team of scientists from the University Paris Descartes has solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics, according to a report in EMBO reports this month. This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.

Frdric Dardel and colleagues crystallized both the narrow and broad-spectrum resistance forms of the antibiotic-modifying acetyltransferase enzyme. Their report reveals that the enzyme has a flexible active site that can evolve to accommodate new antibiotics, allowing the bacteria to break them down and render them useless. This explains why this type of enzyme is now carried by many bacteria struggling for survival in the antibiotic age.

More importantly, the research provides new insight for the design of new antibiotics that could evade this form of resistance, and new inhibitors that would extend the effectiveness of current antibiotics, both of which could help in the fight against the deadly infections becoming more frequent in hospitals.


'/>"/>

Contact: Nonia Pariente
pariente@embo.org
49-622-188-91305
European Molecular Biology Organization
Source:Eurekalert

Page: 1

Related medicine news :

1. U of M researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1
2. Enzyme structure reveals new drug targets for cancer and other diseases
3. Scientists solve structure of gene regulator that plays key role in cancer
4. Porous structures help boost integration of host tissue with implants, study finds
5. Health Capital Group Warns of Fallout to Hospitals From the Subprime Mortgage Crisis and Urges Hospitals to Immediately Reassess Existing Debt Structures and Capital Financing Plans
6. QLT reduces workforce as first step in its strategic restructure
7. Researchers solve first structure of a key to intact DNA inheritance
8. UIC chemists characterize Alzheimers neurotoxin structure
9. Cell Structure Helps Direct Cancer Gene Switch
10. Telomerase enzyme structure provides significant new target for anti-cancer therapies
11. Salem Hospital Selects Phoenix Health Systems for Information Technology Infrastructure Management Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... April 21, 2017 , ... Brady (NYSE:BRC), a global leader ... and B-7569 vinyl label materials received certification for the BS5609 British ... to remain intact and legible, for use on chemical drums shipped by sea. ...
(Date:4/21/2017)... ... ... The adage “Show, don’t tell” applies perfectly to Green Builder Media’s Earth ... House demonstration project series. Manifesting the concept of right-sized living, the Flex House is ... affordably and abundantly without unduly taxing the resources of our beautiful planet. ...
(Date:4/21/2017)... ... 21, 2017 , ... The Hong Kong Polytechnic University (PolyU) launched today the ... education institutions in Hong Kong to support teaching, learning and research. It is also ... of facilities in Hong Kong. , With an area of 620 square metres ...
(Date:4/21/2017)... ... April 21, 2017 , ... Alive for Wellness is a group ... mental health struggles. The Alive team uses advanced behavioral sciences treatment modalities to ... with a mental health struggle is based on 10 modalities of treatment ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... ... Enterprise in the category of International Trade, the UK’s most prestigious award for ... trade, which represents 95% of total revenues and has grown by a total ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Vanderbilt University Medical ... patients in Nashville , Tennesse have ... Esophageal Sphincter Stimulation for GERD (LESS GERD) trial. The ... provide long-term reflux control by restoring normal function to ... 65 million people in the United States ...
(Date:4/19/2017)... , April 19, 2017  New research provides evidence that ... Parkinson,s, according to a study released today that will be ... Meeting in Boston , April 22 ... the treatment of Parkinson,s disease, the oral drug levodopa has ... and longevity. But as the disease progresses, the effects of ...
(Date:4/18/2017)... 2017 Cogentix Medical, Inc. (NASDAQ: CGNT), a ... Uro/Gyn and Gynecology markets with innovative and proprietary products, ... March 31, 2017 after the market close on Tuesday, ... host a conference call and webcast to discuss its ... 2017 at 4:30 p.m. Eastern Time (3:30 p.m. Central ...
Breaking Medicine Technology: