Navigation Links
The stress and cancer link: 'Master switch' stress gene enables cancer's spread
Date:8/22/2013

dditional studies bear out these results, Hai said. In the meantime, she said the results provide important insights into how cells in a tumor use their signaling power to coopt the rest of the body into aiding cancer's survival and movement to distant organs.

The research is published in a recent issue of the Journal of Clinical Investigation.

Hai, a member in the Ohio State University Comprehensive Cancer Center, has studied ATF3 in cancer cells for years. When she had a chance to examine human samples from about 300 breast-cancer patients, she was stunned to find that the expression of ATF3 gene in certain immune-system cells was associated with worse cancer outcomes in this group of patients. ATF3 in cancer cells showed no such association.

To test that clinical data, she and colleagues conducted two rounds of studies in mice. The researchers first injected breast cancer cells into two groups: normal mice and mice that cannot express ATF3 in any cells. The cancer in normal mice metastasized to the lungs far more rapidly and extensively than did cancer in the mice lacking ATF3. In the second round of experiments, they used genetically altered mice that could not express ATF3 in a group of immune system cells called myeloid cells, and the results were similar.

"The cancer cells were always the same, but we had different hosts. The primary tumors were similar in size, but only in the host that can express ATF3 the stress gene did the cancer cells metastasize efficiently," Hai said. "This suggests that the host stress response can help cancer to metastasize.

"If the body is in perfect balance, there isn't much of a problem. When the body gets stressed, that changes the immune system. And the immune system is a double-edged sword," she said.

In general, when cancer cells first appear, the immune system recognizes them as foreign and various immune cells travel to the site to attack them. Early on in cance
'/>"/>

Contact: Tsonwin Hai
Hai.2@osu.edu
614-292-2910
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Mood is influenced by immune cells called to the brain in response to stress
2. Experts Agree Too Much Stress and Too Little Water Are Hidden Causes of Most Disease
3. Thinking about family matters linked to stress for working moms, not dads
4. How parents see themselves may affect their childs brain and stress level
5. Probiotics and Exercise for Anxiety and Stress Reduction Article and Video Released by Health News Wires
6. Dr. Rod J. Rohrich Stresses Role of Evidence-Based Medicine in Plastic Surgery
7. $1.8 Million Grant to Support Research on Impact of Social Stress
8. $1.8 million grant to support research on impact of social stress
9. Pure Prodigy's L-Tyrosine Shown in Studies to Improve Mental Alertness Under Stress
10. Dahryn Trivedi on How Stress Leads to Success and Prosperity
11. Dahryn Trivedi to Deliver Magnetic Insight on the "Benefits of Stress in a Human's Prosperity"
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... 2015 , ... Every year, One-to-1 Fitness and the Red Deer Fit ... Red Deer community with free fitness training and indoor fitness boot camp classes for ... entertainment raised thousands of charity dollars and ended with a $10,000 donation to the ...
(Date:7/2/2015)... VA (PRWEB) , ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to ... 18th sweetFrog store located in the Lone Star State. The premium frozen yogurt chain was ... The store, which opened June 19 in the Village at Bachman Lake, is located at:, ...
(Date:7/2/2015)... ... July 02, 2015 , ... The American Association of ... the Stop Overdose Stat (S.O.S.) Act of 2015 on June 23, 2015. Together ... seeks to decrease drug overdose – especially of heroin and opioid medication – ...
(Date:7/2/2015)... ... , ... With summer in full swing, Americans are flocking to Canada’s many lakes to reel ... fishing in the world, and it’s easy to understand why. From the Pacific Northwest Coast ... , Recreational fishing is a huge industry, and Americans make up the vast majority of ...
(Date:7/2/2015)... ... 02, 2015 , ... As Americans celebrate the Fourth of July outdoors this ... on the rise. July is UV Safety Month, and physicians at American Family Care ... getting skin checks. Experts say most skin cancers can be found early with regular ...
Breaking Medicine News(10 mins):Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 3Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3Health News:Local Physicians Warn of Holiday Health Hazards 2Health News:Local Physicians Warn of Holiday Health Hazards 3Health News:Local Physicians Warn of Holiday Health Hazards 4
... Help Families Organize, Navigate the,Complicated Medical, Education Needs ... Today, the Autism,Society of America (ASA) and MeadWestvaco,s ... to design an autism-themed Cambridge,Planner in honor of ... go on sale at 1,000 Wal-Mart stores nationwide ...
... a type of acute leukemia may occur in part because ... over-activity of genes important to the disease. , , The research ... mutation called NPM1, an alteration seen in about one-third of ... for treating the disease and should improve the understanding of ...
... Association,of Homes and Services for the Aging (AAHSA) ... the Medicare SNF payment system, rationalize,payments and better ... The research presented at today,s MedPAC meeting shows ... payments would shift and - among other,things - ...
... inflammation helps blunt cardiovascular threats, study suggests , , THURSDAY, ... rheumatoid arthritis may also be reducing their risk of ... , People with rheumatoid arthritis (RA), which causes pain, ... face a greater risk of cardiovascular disease, because it ...
... Pharmaceuticals,Inc. (Nasdaq: TRBN ), today announced that it plans ... Dec. 31, 2007, after the,close of market on March 13, ... 2008, at 2 p.m. PDT (5 p.m. EDT)., Third-Quarter ... March,13, 2008, Participants are invited to call 877-545-1491 or ...
... HOUSTON, March 6 Carriage Services, Inc.,(NYSE: CSV ) ... 2008 Outlook that was previously announced on February 4, 2008.,Highlight ... operations for 2006 were as follows:, -- Revenues ... of $150.3 million for 2006. -- Total Field EBITDA ...
Cached Medicine News:Health News:MeadWestvaco and Autism Society of America Launch 2008 ASA Autism Awareness Cambridge Planner 2Health News:MeadWestvaco and Autism Society of America Launch 2008 ASA Autism Awareness Cambridge Planner 3Health News:Low micro-RNA level linked to high gene activity in AML 2Health News:Rheumatoid Arthritis Drugs May Lower Heart Attack, Stroke Risk 2Health News:Trubion Pharmaceuticals Announces Dates for Fourth-Quarter and Year-End 2007 Earnings Conference Call 2Health News:Carriage Services Reports 2007 Full Year Results 2Health News:Carriage Services Reports 2007 Full Year Results 3Health News:Carriage Services Reports 2007 Full Year Results 4Health News:Carriage Services Reports 2007 Full Year Results 5Health News:Carriage Services Reports 2007 Full Year Results 6Health News:Carriage Services Reports 2007 Full Year Results 7Health News:Carriage Services Reports 2007 Full Year Results 8Health News:Carriage Services Reports 2007 Full Year Results 9Health News:Carriage Services Reports 2007 Full Year Results 10Health News:Carriage Services Reports 2007 Full Year Results 11Health News:Carriage Services Reports 2007 Full Year Results 12Health News:Carriage Services Reports 2007 Full Year Results 13Health News:Carriage Services Reports 2007 Full Year Results 14Health News:Carriage Services Reports 2007 Full Year Results 15Health News:Carriage Services Reports 2007 Full Year Results 16Health News:Carriage Services Reports 2007 Full Year Results 17Health News:Carriage Services Reports 2007 Full Year Results 18Health News:Carriage Services Reports 2007 Full Year Results 19Health News:Carriage Services Reports 2007 Full Year Results 20Health News:Carriage Services Reports 2007 Full Year Results 21Health News:Carriage Services Reports 2007 Full Year Results 22Health News:Carriage Services Reports 2007 Full Year Results 23Health News:Carriage Services Reports 2007 Full Year Results 24Health News:Carriage Services Reports 2007 Full Year Results 25Health News:Carriage Services Reports 2007 Full Year Results 26Health News:Carriage Services Reports 2007 Full Year Results 27Health News:Carriage Services Reports 2007 Full Year Results 28Health News:Carriage Services Reports 2007 Full Year Results 29
(Date:7/3/2015)... July 3, 2015 A global ... hypertension, diabetes and thyroid disorders in Latin ... a major conference dedicated to these diseases. ... Online , Manage Hypertension Online and ... by EXCEMED - combine the world,s top ...
(Date:7/3/2015)... , July 3, 2015 Redwood ... Broda Technologies Co., Ltd., operating in both the US ... company,s proprietary IntelliGel ® supramolecular hydrogel technology in ... and other ophthalmic therapies. The Broda technology offers many ... is a free-forming liquid and with low concentrations of ...
(Date:7/2/2015)... N.C. , July 2, 2015 ... employees to capture critical product and market insights ... many benefits to employee-based studies, it is essential ... their own internal employees to capture critical business-related ... by benchmarking firm, Best Practices, LLC, most benchmarked ...
Breaking Medicine Technology:Combating Three Major Chronic Diseases in Latin America With Medical Education 2Redwood Pharma Licenses Novel Hydrogel Drug Delivery Technology From Broda Technologies 2Leveraging Employee Insights to Produce Cutting-Edge Market Research 2
... Physics Consulting, the leading national provider of medical and health physics ... an exclusive arrangement with Digirad Corporation to provide all radiation safety ... division, Digirad Imaging Solutions, Inc. (DIS). , ... "West Physics prides itself on being the ...
... INDIANAPOLIS , May 21 Despite ... of homelessness, Joseph Rogers refused to let ... potential imprint on the world. Despite once being branded ... challenges of being a change agent in mental health ...
Cached Medicine Technology:West Physics Consulting Signs Exclusive Arrangement With Digirad Corporation 2West Physics Consulting Signs Exclusive Arrangement With Digirad Corporation 3West Physics Consulting Signs Exclusive Arrangement With Digirad Corporation 4Annual Welcome Back Awards Program Honors Individuals for Tremendous Contributions to the Depression Community 2Annual Welcome Back Awards Program Honors Individuals for Tremendous Contributions to the Depression Community 3Annual Welcome Back Awards Program Honors Individuals for Tremendous Contributions to the Depression Community 4Annual Welcome Back Awards Program Honors Individuals for Tremendous Contributions to the Depression Community 5Annual Welcome Back Awards Program Honors Individuals for Tremendous Contributions to the Depression Community 6Annual Welcome Back Awards Program Honors Individuals for Tremendous Contributions to the Depression Community 7
VG1 ALIF (Anterior Lateral) Anterior lumbar interbody fusion. Frozen freeze-dried preservation....
Allograft implants can be easily used to repair and promote the healing of a wide variety of bone and other tissue defects....
Allograft implants can be easily used to repair and promote the healing of a wide variety of bone and other tissue defects....
Duet Lumbar Allografts are comprised of a raised cancellous inner core providing biomechanical properties for rapid healing. Specially designed instruments facilitate the insertion of Duet Allografts...
Medicine Products: