Navigation Links
The stemness of cancer cells
Date:12/14/2010

the tumor cell population expands, so goes the prevailing theory, individual cells pick up random mutations, and their molecular identity starts to diverge. By the time the cancer is detected, the millions of cells that make up the tumor have become as different from each other as third cousins twice removed.

There had also been a longstanding notion that fully committed and specialized cells might de-differentiate over the course of tumor initiation and progression, although it was unclear how this might be achieved. Eventually the theory was discarded in favor of the currently fashionable cancer stem cell theory, which holds that cancer stem cells-the cells that propagate a tumor and that could potentially arise from normal stem or early progenitors-are distinct from the bulk of the cancer cells in that they can self-renew as well as produce non-stem cells, just as normal stem cells do.

"Our findings indicate that cancer cells that resemble stem cells need not be part of the original tumor but rather may emerge during later stages of tumor development, facilitated by the loss of p53," says postdoctoral researcher and co-first author Benjamin T. Spike, Ph.D. "The observed tumor heterogeneity is probably a combination of growing genomic instability and epigenetic instability associated with the acquisition of a stem cell-like phenotype."

Wahl and his team first considered the possibility that p53 does more then function as a "genome guardian" when a collaborative study with Juan Carlos Izpisa Belmonte, Ph.D., also a professor in the Gene Expression Laboratory at the Salk Institute, revealed that this tumor suppressor also presents a barrier to somatic cell reprogramming.

To find out whether p53 inactivation does permit the emergence of tumor cells resembling stem cells, Spike and Mizuno combed through hundreds of archival gene expression profiles of breast and lung tumors, searching for stem cell-like signatures and correlating t
'/>"/>

Contact: Gina Kirchweger
858-453-410-01340
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Wistar scientists explain the persistence of melanoma through dynamic stemness
2. Ovarian cancer advances when genes are silenced
3. UCSF tests promising solutions for cancer hair loss
4. Online, Mail Reminders Improve Colon Cancer Screening Rates
5. Road Material in N. Dakota May Up Lung Cancer Risk: Study
6. Certain Drug Combinations May Beat Back Aggressive Breast Cancer
7. Few Lives Saved by Ovarian Cancer Screening: Study
8. Biological diversity of ovarian cancer lessens value of screening
9. Higher co-payments increase chance of early discontinuation of breast cancer therapy
10. Depression drug may relieve pain from breast cancer treatment, U-M study finds
11. Novel imaging technique may reduce lymphedema in breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The stemness of cancer cells
(Date:9/30/2014)... Fla. (PRWEB) September 30, 2014 Lea ... is giving breast cancer patients a new, more practical ... , Women who undergo mastectomies, biopsies and lumpectomy surgeries ... promote healing. But after seeing her patients describe the ... compelled to create a new bra in her spare ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 AxoGen, ... focused on the peripheral nerve repair market, announced the ... during the American Society for Surgery of the Hand ... in Boston. , The ASSH Best ... Utilization of Processed Nerve Allografts for Large Gap Nerve ...
(Date:9/30/2014)... Brig Hart, one of the most ... 500 Diamond-ranked professionals using his systematic way of building ... The Life Support System for Ultimate Success , founded ... using his experiences and successes over the past 30 ... and methodology taught by Brig in this system, Mick ...
(Date:9/30/2014)... 30, 2014 During this online ... approaches to health including achieving hormonal balance, relieving ... and detoxification. , The details ... Date: October 6-9, 2014, Location: Online Event, Registration: ... http://www2.hotzehwc.com/naturalhealthsummitregistration , Monday, October 6th, Steven F. ...
(Date:9/30/2014)... 2014 Timber Home Living Magazine is documenting ... Olsen family’s reclaimed Douglas fir timber frame home in Austerlitz, ... from architectural planning, to the frame raising, to enclosure, to ... Energy Works, after following the timber framing company for years ... dream vacation home on land they fell in love with ...
Breaking Medicine News(10 mins):Health News:Surgeon Creates New Bra for Breast Cancer Patients, Post-Surgery 2Health News:Surgeon Creates New Bra for Breast Cancer Patients, Post-Surgery 3Health News:AxoGen, Inc. Announces Presentation of Clinical Data for Avance® Nerve Graft at American Society for Surgery of the Hand 2014 Annual Meeting 2Health News:AxoGen, Inc. Announces Presentation of Clinical Data for Avance® Nerve Graft at American Society for Surgery of the Hand 2014 Annual Meeting 3Health News:AxoGen, Inc. Announces Presentation of Clinical Data for Avance® Nerve Graft at American Society for Surgery of the Hand 2014 Annual Meeting 4Health News:AxoGen, Inc. Announces Presentation of Clinical Data for Avance® Nerve Graft at American Society for Surgery of the Hand 2014 Annual Meeting 5Health News:Brig Hart Announces the First Diamond Elite Representatives using his Life Support System 2Health News:Brig Hart Announces the First Diamond Elite Representatives using his Life Support System 3Health News:Hotze Health & Wellness Center Announces First Natural Health Summit 2Health News:Reclaimed Timber Frame Home By New Energy Works Featured in Timber Home Living Magazine 2Health News:Reclaimed Timber Frame Home By New Energy Works Featured in Timber Home Living Magazine 3
... one of the most lethal cancers, with fewer than five ... new study that peers deeply into the genetics of pancreatic ... early diagnosis. In contrast to earlier predictions, many pancreatic tumors ... become lethal after the first genetic perturbations appear. "There ...
... People who regularly eat whole grains rather than refined grains ... a higher risk for heart disease and type 2 diabetes, ... (VAT) -- the fat that surrounds the intra-abdominal organs -- ... cholesterol and insulin resistance, health risk factors collectively known as ...
... , TUESDAY, Oct. 26 (HealthDay News) -- As many ... if people followed five simple healthy lifestyle recommendations, Danish ... overall health as well -- include exercise, a good ... weight, the researchers say. "Even a modest difference ...
... University and University of North Carolina (UNC) researchers report ... Research that narcotics and diagnostic testing are overused ... may overlook more effective treatments for neck pain, such ... study, evidence to support the effectiveness of therapeutic exercise ...
... Steven Reinberg HealthDay Reporter , TUESDAY, Oct. 26 ... the blood-thinning drug Plavix (clopidogrel) may be at increased risk ... finds. Having the gene variants seems to reduce the ... developing blood clots in the stent, suffering a heart attack ...
... -- Children who survive cancer face an increased risk ... The findings highlight the increased need for long-term ... researchers said. "Current treatments have dramatically increased survival ... many cancer therapies -- including surgery, radiation, and chemotherapy ...
Cached Medicine News:Health News:Revising the timeline for deadly pancreatic cancer 2Health News:Revising the timeline for deadly pancreatic cancer 3Health News:Eating Whole Grains, Fewer Refined Grains, May Help Heart 2Health News: Healthy Living Can Prevent Nearly 25% of Colorectal Cancers 2Health News: Healthy Living Can Prevent Nearly 25% of Colorectal Cancers 3Health News:Narcotics and diagnostics overused in treatment of chronic neck pain 2Health News:Gene Mutations May Blunt Plavix's Effectiveness, Study Finds 2Health News:Gene Mutations May Blunt Plavix's Effectiveness, Study Finds 3Health News:Childhood Cancer Survivors Risk Future GI Problems 2
(Date:9/30/2014)... DIEGO , Sept. 30, 2014 ... three-dimensional biology company focused on delivering breakthrough 3D ... Liver Model has been selected as a finalist in ... 2014 Most Innovative New Product Awards, sponsored by ... of innovative technology and life sciences products in ...
(Date:9/30/2014)... -- The Corporate Whistleblower Center is urging ER doctors, ... if they have well documented proof of a ... sent home, as an intentional way to overbill ... the Center would like to explain. http://CorporateWhistleblowerCenter.Com ... Photo - http://photos.prnewswire.com/prnh/20140929/149017 ...
(Date:9/30/2014)... EXECUTIVE SUMMARY The present report ... - Increasing Demand from Ageing Population to Drive ... past, present and future outlook. The report discusses ... market with outlook to 2017. Statistics include functional ... sub-segments of the industry, ongoing trends and developments, ...
Breaking Medicine Technology:Organovo Inc. Selected As A Finalist In 27th Annual CONNECT Most Innovative New Product Awards 2Organovo Inc. Selected As A Finalist In 27th Annual CONNECT Most Innovative New Product Awards 3Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 2Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 3Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 4North America Nutraceuticals Industry Outlook to 2017- Increasing Demand from Ageing Population to Drive Growth 2North America Nutraceuticals Industry Outlook to 2017- Increasing Demand from Ageing Population to Drive Growth 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: