Navigation Links
The small cell neuroendocrine carcinoma of the ampulla of vater

Ampullary small cell neuroendocrine carcinoma is extremely rare and has only been documented in few case reports and retrospective study. The patients with ampullary small cell neuroendocrine carcinoma usually presented after the age of 60 years, and a male predilection was observed. Only two cases of a small cell neuroendocrine carcinoma associated with an adenoma have been described in a retrospective study. There has been no radiology report describing the imaging features of these coexisting tumors of the ampullary region.

An article published on August 7, 2008 in the World Journal of Gastroenterology addresses this report. The medical team composed of Dr. Sun JH and his colleagues from Second Affiliated Hospital and Sir Run Run Shaw Hospital, Zhejiang University revealed the novel case based on the clinical, histopathological and radiological features.

A 74-year-old man presented with a 3 week history of abdominal discomfort and jaundice. Abdominal ultrasonography, computed tomography (CT) and MR cholangiogram (MRCP) showed two well-defined masses in the ampullary region, dilated bile ducts and pancreatic duct, and peripancreatic lymphadenopathy. The patient underwent Whipple's operation with local lymph node dissection. Histopathology after the operation revealed the coexistence of a small cell neuroendocrine carcinoma and a villous adenoma in the ampulla of Vater. Unfortunately, the patient died of pneumonia 3 months after the operation.

The preoperative diagnosis of these rare tumors in the ampulla is potentially problematic. CT finding of a polypous mass with a long pedicle was helpful to diagnose an adenoma. However, it may not be possible to differentiating ampullary small cell neuroendocrine carcinoma from ampullary adenocarcinoma on CT. Thus, small cell neuroendocrine carcinoma should be included in the differential diagnosis of ampullary masses especially when the patient is an old male. These tumors' associations suggest a common origin in the ampulla of Vater. It is probable that the two neoplasms originate from non-neoplastic multipotent stem cells that terminally differentiate into all kinds of epithelial cells including ciliated cells, mucous cells and endocrine cells.


Contact: Lai-Fu Li
World Journal of Gastroenterology

Related medicine news :

1. Discoverers of Small Regulatory RNAs and Cholesterol-Lowering Drugs to Receive Lasker Awards for Medical Research
2. Baird Hosts Small Cap Health Care Conference : Senior Healthcare Distribution & Services Research Analyst Eric Coldwell Shares Insights on Sector
3. Conventions Conclude, Fall Campaign Begins: NFIB Looks for More Focus on Small Business Healthcare Concerns
4. Health Insurance Industry Listens to Health Care Concerns of Utah Small Business Owners
5. Managed Compliance Services Program (MCSP) Introduced for Small Healthcare Practitioners
6. Epilepsy drug may help alcoholics recover from dependence, small study suggests
7. Malaria Vaccine Developer Sanaria Inc. and the University of Maryland Biotechnology Institute Awarded Collaborative, Multi-Year, US $600,000 NIH Phase I Small Business Innovation Research Grant
8. The Five Biggest Marketing Mistakes Made By Medical Offices and Small Businesses
9. Mesa Laboratories, Inc. Named to Fortune Small Business Magazines 2008 List
10. Seizures in newborns can be detected with small, portable brain activity monitors
11. PA ABC Health Care Proposal Will Benefit Small Businesses, Revenue Secretary Says
Post Your Comments:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... As health ... medicine known as “patient engagement.” The patient is doing more than filling out a ... , “There is an increasing emphasis in health care and research on the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of ... collection of specialty vendors and unique items from across the nation, this holiday-themed event ... wellness services offered by the VNA. The boutique will be open Saturday, November ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... SAN DIEGO , Sept. 22, 2017 ... ll medical device is now successfully helping those with ... Union. Fibromyalgia diagnosed Amanda in ... getting dressed and washing my hair, experiencing no sleep ... body in painful spasm… I cannot recommend [the AVACEN ...
(Date:9/19/2017)... Ky. , Sept. 19, 2017   ZirMed Inc ... predictive analytics, today announced that it has been ranked #1 ... Black Book™ Rankings 2017 User Survey. ZirMed was ... solution for large hospitals and medical centers over 200 beds ... Black Book,s healthcare technology user survey history. ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: