Navigation Links
The search for predictors of risk for PTSD
Date:9/5/2011

ATLANTA Data in a study published in the Archives of General Psychiatry suggest that certain variants of a gene that helps regulate serotonin (a brain chemical related to mood), may serve as a useful predictor of risk for symptoms related to posttraumatic stress disorder (PTSD) following a trauma.

"One of the critical questions surrounding PTSD is why some individuals are at risk for developing the disorder following a trauma, while others appear to be relatively resilient," says lead author, Kerry J. Ressler, MD, PhD, Howard Hughes Medical Institute investigator and professor in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine.

"It is known that genetic heritability is one component of the differential risk for PTSD, but the mechanisms remain relatively unknown."

In this study, the researchers were able to look at college students who had been interviewed for a study prior to a 2008 mass shooting on the Northern Illinois University campus, and then were interviewed afterward. The researchers used these prospective psychological data to examine the association between variants in the serotonin transporter gene promoter region of the brain, and PTSD/acute stress disorder symptoms that developed in the aftermath of exposure to the shooting.

"We believe that the strength of this study is the availability of the same validated survey measure to assess PTSD symptoms prior to and after a shared acute traumatic event," explains Ressler, who is also a researcher at the Yerkes National Primate Research Center at Emory.

The data suggest that differential function of the serotonin transporter may mediate differential response to a severe trauma. This is interesting because the gene product is the target for the first-line treatment for PTSD, the selective serotonin reuptake inhibitors (SSRIs). Additionally, variants in the gene have previously been shown to be associated with different risk for depression following life stress.

The researchers concluded that when examined in a relatively homogenous sample with shared trauma and known prior levels of child and adult trauma, this serotonin transporter genotype may serve as a useful predictor of risk for PTSD related symptoms in the weeks and months following trauma.

Importantly, notes Ressler, this is one of likely a number of genes that will ultimately be found to contribute to risk and resilience. As more of these gene pathways are understood, it is hoped that such findings will contribute to improved treatment and prevention as well as better prediction of risk for PTSD following traumatic exposure.


'/>"/>

Contact: Kathi Baker
kobaker@emory.edu
404-227-1871
Emory University
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Nationwide Video Search Kicks off Ban Asbestos Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2017)... ... , ... More than half of Americans suffering from noise-induced hearing loss do ... that causes hearing loss? May 1 marks the beginning of Better Hearing & Speech ... well as schedule a hearing evaluation for anyone with concerns about his/her hearing. , ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... (The National Campaign) announces its support for the Access to Contraception for Women ... Shaheen (D-NH) and Rep. Jackie Speier (D-CA), will help to ensure that all ...
(Date:4/28/2017)... ... April 28, 2017 , ... Somnoware, a leading provider of ... which enables sleep physicians to create and edit their interpretation reports. This solution ... a familiar interface that does not require additional training to use. It also ...
(Date:4/28/2017)... ... ... affects much more than energy – it also has mental and physical benefits. According to ... time, which can increase the risk of having a car accident. , This week ... to help you sleep better and feel better:, , Turn off ...
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio America proudly introduces ... an instant energy-saving solution for F32T8 fluorescent lamps on most instant-start and programmed-start ... 50,000 hour rated lamps utilize the existing electronic ballast, saving labor and maintenance ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 Research and ... Technologies - Innovation Driven by Rapidly Expanding Injectables Market and Increasing ... their offering. ... for drug delivery technologies will rise from USD 20 Billion in ... Global Drug Delivery Technologies - Innovation Driven by Rapidly Expanding ...
(Date:4/20/2017)... , April 20, 2017 Research ... Pharmacogenomics Market Size, Market Share, Application Analysis, Regional Outlook, Growth ... report to their offering. ... The global pharmacogenomics market was valued at US$ 7,167.6 ... Mn by 2024, expanding at a CAGR of 5.6% from ...
(Date:4/19/2017)... Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), announces that it ... 2017 at the Sheraton Hotel in Toronto, Ontario ... the Company is scheduled to present on Tuesday, May 2 at ... Chairman of the Board, Tony Holler will also attend ... For more details ...
Breaking Medicine Technology: