Navigation Links
The search for an early biomarker to fight atherosclerosis
Date:5/13/2013

Montral, May 14, 2013 It's on Saturday that the Journal of the American Heart Association published the conclusive results from a study directed by Dr. ric Thorin of the Montreal Heart Institute (MHI), which suggests for the first time that a blood protein contributes to the early development of atherosclerosis.

Dr. Thorin, his team and his collaborators discovered that the blood levels of angiopoietin-like protein 2 (angptl2) are six times higher in subjects with coronary heart disease than in healthy subjects of the same age. Their basic research study also revealed that angptl2, which is undetectable in young mice, increases with age in healthy subjects and increases prematurely in subjects who have high cholesterol and pre-atherosclerotic lesions. Entitled "Angiopoietin-like 2 promotes atherogenesis in mice," this study was conducted using an animal model consisting of three to twelve-month-old mice.

These results represent a major advance in the prevention and treatment of atherosclerosis. "Although much work remains to be done to broaden our knowledge of this protein's mechanisms of action, angiopoietin-like protein 2 may represent an early biomarker not only to prevent vascular damage but also to predict atherosclerotic disease," explained Dr. Thorin.

For 15 years, Dr. Thorin, a researcher at the MHI Research Centre and full professor at Universit de Montral, has been interested in the evolution of artery function during the aging process and in the underlying mechanisms of atherosclerosis. More specifically over the past five years, he has looked at the role of this particular protein. Thanks to his work, we now know that angptl2 causes a high degree of vascular inflammation. Blood levels of this protein increase in patients with cardiovascular disease as well as in people with complications related to diabetes, obesity and cancer in which the small blood vessels are damaged, as all of these diseases are associated with chronic inflammation.

According to Dr. Anil Nigam, a cardiologist and specialist in cardiovascular disease prevention at the MHI and co-author of the study, "Prevention is the ideal solution to delay the onset of atherosclerosis, and an early blood marker such as angptl2if future clinical studies confirm this findingwill serve as an important tool to identify at-risk subjects who do not present with any symptoms of atherosclerotic disease."


'/>"/>

Contact: Marie-Josée Nantel
marie-josee.nantel@icm-mhi.org
514-376-3330
Montreal Heart Institute
Source:Eurekalert

Related medicine news :

1. Beaumont cardiologist Kavitha Chinnaiyan, M.D., receives excellence in research award
2. Most Michigan parents, grandparents prefer research hospitals for pediatric care
3. Leap in leukemia treatment reported by Dartmouth researchers
4. Researchers discover master regulator that drives majority of lymphoma
5. Global Cell Culture Market - New Market Research Report Published by Transparency Market Research
6. Researchers develop smart phone app to help weight loss
7. Food Allergy Research & Education (FARE) Takes Action to Address Growing Problem of Food Allergy Bullying
8. POC Abused Drugs & Lipid Testing Market Analysis For US, Germany & Spain in New Research Reports at RnRMarketResearch.com
9. Global Reinsurance Carriers Industry Market Research Report from IBISWorld Has Been Updated
10. Bix of Sanders-Brown receives NIH funding for stroke research
11. Mount Sinai Researchers Identify Gene Mutations in Congenital Heart Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... The ThedaCare Center for ... General Hospital on April 5-7. The series is a multi-day, multi-workshop event designed ... workshops cover a broad range of topics, including coaching skills, the scientific method ...
(Date:2/12/2016)... Las Vegas, NV (PRWEB) , ... February 12, 2016 , ... ... of North Las Vegas Mayor John J. Lee, Nevada Military Support Alliance president Scott ... newest Fisher House at the VA Southern Nevada Healthcare System. This will be ...
(Date:2/12/2016)... ... February 12, 2016 , ... Vail knee specialist Robert LaPrade, MD, ... in 2016 . The list consists of physicians establishing, leading and partnering with ambulatory ... , An Ambulatory Surgery Center, also known as an ASC, is a modern ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Donor Network West, ... California and Nevada, announced a partnership with San Ramon Regional Medical Center. Under the ... hospital’s facilities as a way to accommodate a more certain time frame for donor ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... southwest Houston and surrounding communities by continuing it’s commitment to act as Agents ... Promise. The organization works closely with area homeless families to fulfill immediate needs ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Kindred Biosciences, Inc. ... saving and improving the lives of pets, today announced ... of the New Animal Drug Application (NADA) for Zimeta™ ... field study (KB0120) of Zimeta for the control of ... Company. --> --> ...
(Date:2/11/2016)... FRANCISCO , Feb. 11, 2016   Health ... advancement of new health technologies, announced today " 10 ... achievements in health tech over the past ten years.   ... For nearly a decade, Health 2.0 has served as ... showcased and connected with thousands of technologies, companies, innovators, ...
(Date:2/11/2016)... Feb. 11, 2016  MiMedx Group, Inc. (NASDAQ: ... amniotic membrane and other birth tissues, human skin and ... and market advanced products and therapies, announced today that ... Global Healthcare Conference in New York ... Michael J. Senken , Chief Financial Officer and ...
Breaking Medicine Technology: