Navigation Links
The search for an early biomarker to fight atherosclerosis
Date:5/13/2013

Montral, May 14, 2013 It's on Saturday that the Journal of the American Heart Association published the conclusive results from a study directed by Dr. ric Thorin of the Montreal Heart Institute (MHI), which suggests for the first time that a blood protein contributes to the early development of atherosclerosis.

Dr. Thorin, his team and his collaborators discovered that the blood levels of angiopoietin-like protein 2 (angptl2) are six times higher in subjects with coronary heart disease than in healthy subjects of the same age. Their basic research study also revealed that angptl2, which is undetectable in young mice, increases with age in healthy subjects and increases prematurely in subjects who have high cholesterol and pre-atherosclerotic lesions. Entitled "Angiopoietin-like 2 promotes atherogenesis in mice," this study was conducted using an animal model consisting of three to twelve-month-old mice.

These results represent a major advance in the prevention and treatment of atherosclerosis. "Although much work remains to be done to broaden our knowledge of this protein's mechanisms of action, angiopoietin-like protein 2 may represent an early biomarker not only to prevent vascular damage but also to predict atherosclerotic disease," explained Dr. Thorin.

For 15 years, Dr. Thorin, a researcher at the MHI Research Centre and full professor at Universit de Montral, has been interested in the evolution of artery function during the aging process and in the underlying mechanisms of atherosclerosis. More specifically over the past five years, he has looked at the role of this particular protein. Thanks to his work, we now know that angptl2 causes a high degree of vascular inflammation. Blood levels of this protein increase in patients with cardiovascular disease as well as in people with complications related to diabetes, obesity and cancer in which the small blood vessels are damaged, as all of these diseases are associated with chronic inflammation.

According to Dr. Anil Nigam, a cardiologist and specialist in cardiovascular disease prevention at the MHI and co-author of the study, "Prevention is the ideal solution to delay the onset of atherosclerosis, and an early blood marker such as angptl2if future clinical studies confirm this findingwill serve as an important tool to identify at-risk subjects who do not present with any symptoms of atherosclerotic disease."


'/>"/>

Contact: Marie-Josée Nantel
marie-josee.nantel@icm-mhi.org
514-376-3330
Montreal Heart Institute
Source:Eurekalert

Related medicine news :

1. Beaumont cardiologist Kavitha Chinnaiyan, M.D., receives excellence in research award
2. Most Michigan parents, grandparents prefer research hospitals for pediatric care
3. Leap in leukemia treatment reported by Dartmouth researchers
4. Researchers discover master regulator that drives majority of lymphoma
5. Global Cell Culture Market - New Market Research Report Published by Transparency Market Research
6. Researchers develop smart phone app to help weight loss
7. Food Allergy Research & Education (FARE) Takes Action to Address Growing Problem of Food Allergy Bullying
8. POC Abused Drugs & Lipid Testing Market Analysis For US, Germany & Spain in New Research Reports at RnRMarketResearch.com
9. Global Reinsurance Carriers Industry Market Research Report from IBISWorld Has Been Updated
10. Bix of Sanders-Brown receives NIH funding for stroke research
11. Mount Sinai Researchers Identify Gene Mutations in Congenital Heart Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... Linda, Ca (PRWEB) , ... February 27, 2017 ... ... Life Sciences, provides an overview on laser diffraction analysis as a tool to ... its capabilities, significance and potential to obtain improved results and novel scientific findings. ...
(Date:2/27/2017)... , ... February 27, 2017 , ... POUGHKEEPSIE, N. Y. ... has disclosed that despite scientific studies, the Center for Disease Control ( CDC ) ... disease . Kenneth B. Liegner, M.D. has compiled into a single volume a ...
(Date:2/27/2017)... ... February 27, 2017 , ... Sunshine Coast ... in British Columbia, Canada, at https://www.sunshinecoasthealthcentre.ca/ , is proud to announce the ... Mackenzie Alsager, showcases the Centre's commitment to innovation in drug rehab and alcohol ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley Hair Institute, a ... an upgrade to the company's Yelp listing. Bay Area residents struggling from thinning ... as Platelet Rich Plasma (PRP) therapy, hair transplantation techniques such as Follicular Unit ...
(Date:2/26/2017)... ... 25, 2017 , ... The February 13, 2017, assassination of Kim Jong-nam, the ... agents and the deadly use of chemical weapons. Many questions exist about the effect ... doses can be lethal. , Jay Jagannathan, M.D., of Michigan-based Jagannathan Neurosurgical Institute, and ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... 2017 Mederi Therapeutics today announced the ... 2468 patients who received  Stretta Therapy  to treat ... Systematic Review and Meta-Analysis of Controlled and Prospective ... of Gastroesophageal Reflux Disease ", was published in ... , MD, head of the Esophageal and Swallowing ...
(Date:2/27/2017)... Feb. 27, 2017  International Biophysics Corporation, a global medical ... today announced a 34% revenue growth in 2016 when compared ... unit sales.  This growth was fueled by its AffloVest® sales ... to the expansion of its global sales of surgical product ... CEO, "As we enter our 25 th year in ...
(Date:2/27/2017)... 2017  Infinity Pharmaceuticals, Inc. (NASDAQ: INFI ... 37 th Annual Healthcare Conference on Monday, March ... Boston, MA. A live webcast of Infinity,s ... Infinity,s website at www.infi.com , and will be ... About Infinity,Infinity is an innovative biopharmaceutical company dedicated to ...
Breaking Medicine Technology: