Navigation Links
The safety of daily magnesium oxide treatment for children with chronic constipation
Date:3/8/2011

Magnesium-containing cathartics are commonly used to treat chronic constipation. Although hypermagnesemia is a rare clinical condition, it can occur as a side effect of increased intake of magnesium salts. The Japanese government has recently reported fatal cases of hypermagnesemia in adults treated with magnesium oxide. It is now important for pediatricians to know whether hypermagnesemia can develop in children with functional constipation who are receiving daily magnesium oxide treatment.

A research article to be published on February 14, 2011 in the World Journal of Gastroenterology addresses this question. The authors enrolled 120 patients (57 male and 63 female) aged 1󈝺 years old (median: 4.7 years old) with functional constipation from 13 hospitals and two private clinics. All patients fulfilled the Rome III criteria for functional constipation and were treated daily with oral magnesium oxide for at least 1 mo. The median treatment dose was 600 (500�) mg/d. Patients were assessed by interview and laboratory examination to determine possible hypermagnesemia. Serum magnesium concentration was also measured in sex- and age-matched control subjects (n = 38).

Serum magnesium concentrations increased significantly after daily magnesium oxide treatment, but the magnitude of the increase appeared modest. Serum magnesium level decreased significantly with age in constipated children treated with magnesium oxide, but not in the control children. No correlation was found between duration of treatment or daily dose of magnesium oxide and serum magnesium concentration.

The authors concluded that serum magnesium concentrations increase significantly after daily magnesium oxide intake, but the magnitude of the increase appears modest. Younger age, but not prolonged use of daily magnesium oxide might be a relative risk factor, and it should be determined by further studies whether serum magnesium concentration should be assessed in these subjects.


'/>"/>

Contact: Ye-Ru Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. New UCSF robotic pharmacy aims to improve patient safety
2. Perinatal safety initiative reduces adverse obstetrical outcomes
3. RA sufferers armed with kitchen safety tool
4. Supreme Court Rejects Vaccine-Safety Lawsuit
5. ASGE recognizes 35 endoscopy units for quality and safety as part of its Endoscopy Unit Recognition Program
6. Spate of Hunter Injuries Spurs New Call for Tree Stand Safety
7. Take Safety Precautions in the Snow, Ice
8. Safety checklist use yields 10 percent drop in hospital deaths
9. More doctors must join nurses, administrators in leading efforts to improve patient safety, outcomes
10. Linhardt to discuss drug safety and the impacts of globalization on pharmaceutical manufacturing
11. Study raises safety concerns about experimental cancer approach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... September 22, 2017 , ... PITTSBURGH...Defibrillators are ... saves lives. However, if one isn’t accessible in certain locations, the risk of ... I came up with this idea," said an inventor from Ridgecrest, Calif. , ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... Safe Is Smart Scholarship Sweepstakes.,  , Molli C., a graduate student from Sonora, ... Educational Leadership and Administration at St. Thomas University in Miami, Florida, was selected ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... emergency rooms is celebrating the one year anniversary of its Houston-Fallbrook facility. ... said Dr. Otinwa, Facility Medical Director of First Choice Emergency Room Houston-Fallbrook. “It ...
(Date:9/22/2017)... Diego, CA (PRWEB) , ... September 22, 2017 ... ... offer groceries, wearable, and more products at customers’ doorstep. According to Smart Mart, ... Smart Mart has stated to offer wearable, and customers can find clothing at ...
(Date:9/21/2017)... ... September 21, 2017 , ... Process ... 1:30 p.m. – 3:00 p.m. ET, http://www.fdanews.com/processcapabilityindices      , ... wrong, run afoul of The Quality System Regulation (§820.250), and Devicemakers find themselves ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... Eli Lilly and Company (NYSE: LLY ) ... and lasmiditan, two investigational treatments for migraine, at the ... place Sept. 7-10 in Vancouver . ... from an open-label study evaluating the safety and effectiveness ... mg) for the prevention of migraine. Galcanezumab is a ...
(Date:9/5/2017)... Sept. 5, 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... clinical-stage pharmaceutical company focused on the development of oral ... concluded its meeting with the U.S. Food and Drug ... formulation. At the ... pathway for submission of ORMD-0801, would be a Biologics ...
(Date:8/29/2017)... 2017 ivWatch, LLC, the leading provider of continuous monitoring ... has been awarded an Innovative Technology contract from Vizient, Inc., the ... ... in the early detection of peripheral IV infiltration and extravasation events ... The Innovative Technology contract was awarded to ...
Breaking Medicine Technology: