Navigation Links
The safety of daily magnesium oxide treatment for children with chronic constipation
Date:3/8/2011

Magnesium-containing cathartics are commonly used to treat chronic constipation. Although hypermagnesemia is a rare clinical condition, it can occur as a side effect of increased intake of magnesium salts. The Japanese government has recently reported fatal cases of hypermagnesemia in adults treated with magnesium oxide. It is now important for pediatricians to know whether hypermagnesemia can develop in children with functional constipation who are receiving daily magnesium oxide treatment.

A research article to be published on February 14, 2011 in the World Journal of Gastroenterology addresses this question. The authors enrolled 120 patients (57 male and 63 female) aged 1󈝺 years old (median: 4.7 years old) with functional constipation from 13 hospitals and two private clinics. All patients fulfilled the Rome III criteria for functional constipation and were treated daily with oral magnesium oxide for at least 1 mo. The median treatment dose was 600 (500�) mg/d. Patients were assessed by interview and laboratory examination to determine possible hypermagnesemia. Serum magnesium concentration was also measured in sex- and age-matched control subjects (n = 38).

Serum magnesium concentrations increased significantly after daily magnesium oxide treatment, but the magnitude of the increase appeared modest. Serum magnesium level decreased significantly with age in constipated children treated with magnesium oxide, but not in the control children. No correlation was found between duration of treatment or daily dose of magnesium oxide and serum magnesium concentration.

The authors concluded that serum magnesium concentrations increase significantly after daily magnesium oxide intake, but the magnitude of the increase appears modest. Younger age, but not prolonged use of daily magnesium oxide might be a relative risk factor, and it should be determined by further studies whether serum magnesium concentration should be assessed in these subjects.


'/>"/>

Contact: Ye-Ru Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. New UCSF robotic pharmacy aims to improve patient safety
2. Perinatal safety initiative reduces adverse obstetrical outcomes
3. RA sufferers armed with kitchen safety tool
4. Supreme Court Rejects Vaccine-Safety Lawsuit
5. ASGE recognizes 35 endoscopy units for quality and safety as part of its Endoscopy Unit Recognition Program
6. Spate of Hunter Injuries Spurs New Call for Tree Stand Safety
7. Take Safety Precautions in the Snow, Ice
8. Safety checklist use yields 10 percent drop in hospital deaths
9. More doctors must join nurses, administrators in leading efforts to improve patient safety, outcomes
10. Linhardt to discuss drug safety and the impacts of globalization on pharmaceutical manufacturing
11. Study raises safety concerns about experimental cancer approach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... ... American Osteopathic Association’s (AOA) Match Program Tuesday, February 9, taking one of the ... into osteopathic graduate medical education positions across the country. Of the 103 student-doctors ...
(Date:2/11/2016)... ... 2016 , ... Image One USA veteran franchise owner Maria Bogacki ... buildings of Nashville that will benefit. , “I’ve enjoyed being a part of the ... was no question that I would bring my business with me,” Bogacki said. “The ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... and women’s health, is pleased to announce the promotions of Allison Kelly to ... team, Steve Catone to executive vice president of North American capital sales, and ...
(Date:2/11/2016)... ISLAND, Australia (PRWEB) , ... February 11, 2016 ... ... full potential ?" motivational speaker, trainer and author Ray Clarke poses a question ... personal fulfillment . In his book, "Being in the Being" (published by ...
(Date:2/11/2016)... ... February 11, 2016 , ... AccuVein ... resource, Infusion Therapy Standards of Practice, to include vascular visualization as a standard ... estimated 85% share of the market, facilitates adherence to this standard with its ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Potrero Medical, Inc., the developer of the Accuryn™ ... of George M. Rapier, III , MD, to its ... , WellMed is one of the nation,s largest physician owned ... in Texas and Florida ... own internal medicine practice, he has been instrumental to the ...
(Date:2/11/2016)... Feb. 11, 2016 AAIPharma Services Corp./Cambridge ... custom manufacturing and development services for the pharmaceutical ... capabilities and capacity in its Charleston, ... has driven several recent investments. ... one filling line with small-scale lyophilization. The site ...
(Date:2/11/2016)... , Feb. 11, 2016 Wearable posture tracker, ALEX , has taken Kickstarter by ... and just seven days left to go, ALEX is said to be delivered to backers starting May ... ... ... Created by ...
Breaking Medicine Technology: