Navigation Links
The role of sleep in brain development
Date:2/21/2010

Marcos Frank, PhD, associate professor of Neuroscience at the University of Pennsylvania School of Medicine, will present information on early brain development and the importance of sleep during early life when the brain is rapidly maturing and highly changeable.

Building on his research that the brain during sleep is fundamentally different from the brain during wakefulness, Dr. Frank has found that cellular changes in the sleeping brain that may promote the formation of memories. "This is the first real direct insight into how the brain, on a cellular level, changes the strength of its connections during sleep," Frank says.

When an animal goes to sleep it's like a switch is thrown, everything is turned on that's necessary for making synaptic changes that form the basis of memory formation. The team used an animal model of cortical plasticity the making and breaking of neural connections in response to life experiences. They found that once the brain is triggered to reorganize its neural networks in wakefulness (by visual deprivation, for instance), intra- and intercellular communication pathways engage, setting a series of enzymes into action within the reorganizing neurons during sleep. The key cellular player in this process is a molecule called N-methyl D-aspartate receptor (NMDAR), which acts like a combination listening post and gate-keeper. It both receives extracellular signals in the form of glutamate and regulates the flow of calcium ions into cells.

"As soon as the animal had a chance to sleep, we saw all the machinery of memory start to engage." Frank will discuss recent experiments and how these relate to memory formation at the molecular level, why humans need sleep, and why they are so affected by the lack of it.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Severe Sleep Apnea Has Silver Lining
2. Severe sleep apnea decreases frequency of nightmare recall
3. Sleep problems and sleepiness increase the risk of motor vehicle accidents in adolescents
4. Behavioral therapy improves sleep and lives of patients with pain
5. Solutions for Sleep Problems: Harvard's Improving Sleep Special Health Report and New Sleep Apnea Video
6. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
7. Sleep HealthCenters to Sponsor North East Sleep Society 2010
8. Obstructive Sleep Apnea in Kids May Have Genetic Cause
9. Family meals, adequate sleep and limited TV may lower childhood obesity
10. Sleep Expert on "Sleep Talkin' Man:" It Could Happen To Anyone
11. Artificial Pancreas Helps Type 1 Diabetics During Sleep
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
Breaking Medicine Technology: