Navigation Links
The role of sleep in brain development
Date:2/21/2010

Marcos Frank, PhD, associate professor of Neuroscience at the University of Pennsylvania School of Medicine, will present information on early brain development and the importance of sleep during early life when the brain is rapidly maturing and highly changeable.

Building on his research that the brain during sleep is fundamentally different from the brain during wakefulness, Dr. Frank has found that cellular changes in the sleeping brain that may promote the formation of memories. "This is the first real direct insight into how the brain, on a cellular level, changes the strength of its connections during sleep," Frank says.

When an animal goes to sleep it's like a switch is thrown, everything is turned on that's necessary for making synaptic changes that form the basis of memory formation. The team used an animal model of cortical plasticity the making and breaking of neural connections in response to life experiences. They found that once the brain is triggered to reorganize its neural networks in wakefulness (by visual deprivation, for instance), intra- and intercellular communication pathways engage, setting a series of enzymes into action within the reorganizing neurons during sleep. The key cellular player in this process is a molecule called N-methyl D-aspartate receptor (NMDAR), which acts like a combination listening post and gate-keeper. It both receives extracellular signals in the form of glutamate and regulates the flow of calcium ions into cells.

"As soon as the animal had a chance to sleep, we saw all the machinery of memory start to engage." Frank will discuss recent experiments and how these relate to memory formation at the molecular level, why humans need sleep, and why they are so affected by the lack of it.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Severe Sleep Apnea Has Silver Lining
2. Severe sleep apnea decreases frequency of nightmare recall
3. Sleep problems and sleepiness increase the risk of motor vehicle accidents in adolescents
4. Behavioral therapy improves sleep and lives of patients with pain
5. Solutions for Sleep Problems: Harvard's Improving Sleep Special Health Report and New Sleep Apnea Video
6. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
7. Sleep HealthCenters to Sponsor North East Sleep Society 2010
8. Obstructive Sleep Apnea in Kids May Have Genetic Cause
9. Family meals, adequate sleep and limited TV may lower childhood obesity
10. Sleep Expert on "Sleep Talkin' Man:" It Could Happen To Anyone
11. Artificial Pancreas Helps Type 1 Diabetics During Sleep
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 2017 , ... “The Communion of Saints: A Pastor’s Potpourri ... congregations across the United States. “The Communion of Saints” is the creation ... served congregations in seven states throughout his long career of devotion to the ...
(Date:3/23/2017)... Seattle, WA (PRWEB) , ... March 23, 2017 , ... ... emergency and now estimates that there could be four million Zika-related cases in the ... to date with numbers of US cases reported per year skyrocketing to an estimated ...
(Date:3/23/2017)... ... March 23, 2017 , ... The physicians of KSF Orthopaedic ... greater Houston Area. The new location is located at 2255 E. Mossy Oaks Rd., ... Village. This newest location will provide patients living in the north Houston area (The ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... Texas ... located at 960 Gruene Road in Building 2. The clinic is the group’s second ... Bennett, PT, says opening the company’s second New Braunfels location brings things full circle ...
(Date:3/23/2017)... Minneapolis, MN (PRWEB) , ... March 23, 2017 , ... ... with internet and WiFi connectivity are making a huge impact on businesses and individual ... Global Institute estimates the IoT will have a value anywhere from $4 trillion to ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... BARBARA, Calif. and INDIANAPOLIS ... (NYSE: LLY ) and the William Sansum ... the lives of Latino people affected by diabetes through ... tremendous burden of diabetes and cardiovascular disease bears a ... United States ," said David Kerr , ...
(Date:3/23/2017)... , March 23, 2017  The U.S. Food ... (avelumab) for the treatment of adults and pediatric patients ... (MCC), including those who have not received prior chemotherapy. ... a rare, aggressive form of skin cancer. ... cancers, patients with a rare form called Merkel cell ...
(Date:3/23/2017)... MOINES, Iowa , March 23, 2017   ... and career resource, has partnered with Indiana Biosciences ... Indiana organizations and educational institutions to bring ... with the first-ever BioIndiana Hotbed map, an artistic representation ... framed print was presented to Vice President Mike ...
Breaking Medicine Technology: