Navigation Links
The right dose for oncology
Date:3/4/2013

King Mithridates understood that poison is only as good as the dosage taken. Each day, he ingested small quantities of poison in order to become immunize and escape his court's plotters. Oncologists run up against the same principle when fighting cancer. Sometimes, a small dose of chemotherapy may induce dangerous resistance mechanisms in malignant cells, resulting in relapse. Now, EPFL research published in the journal PLOS ONE reports a tool that could simply and accurately determine the right dose for individual patients.

Dosage, a vital issue

This novel tool, developed by Philippe Renaud's team at EPFL, is based on a very simple principle: a cell's electrical conductivity depends on the level of stress induced by chemotherapy. In broad terms, by measuring a cancerous cell's capacity to conduct electricity, researchers can assess the intensity of the treatment's effect.

"When chemotherapy induces very little stress in cells, particularly after the application of a small dose, there is a problem," says Robert Meissner, a co-author of the study. "Not only is its effect not sufficient to kill the affected cells, but this actually increases the risk of inducing resistance, which will eventually make the treatment ineffective."

This is vital during relapse as cells have already developed resistance mechanisms and sometimes oncologists don't have an effective alternative therapy. Hence, it is fundamental to apply the right dose from the start.

Step towards personalized oncology

The method developed at EPFL could help doctors make more patient-specific decisions. "We fully subscribe to the trend of personalized medicine," explains Philippe Renaud. "By making a simple biopsy, oncologists could test the way a particular patient's cells respond to different types of treatments at various doses."

The tool, which was designed for a clinical environment, provides a simple and fast analysis without affecting the treated cells. Unlike methods based on biomarkers, which kill cells and are extremely strenuous to perform, the EPFL technology could be implemented easily in a medical environment. In fact, scientists have already tested it on malignant breast cells treated with a standard drug, doxorubicin.

The EPFL team is currently in discussion with oncologists to continue jointly developing their procedure. Within a few months, researchers say, a startup company will likely be created to help bring the laboratory work into the hospital setting.


'/>"/>

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Related medicine news :

1. Skechers Lawsuit Filed On Behalf of Ohio Woman, Alleging That the Defective Design of Shape-Ups Caused the Plaintiff’s Serious Knee Injuries, by Wright & Schulte
2. Skechers Lawsuit Has Been Filed by Wright & Schulte on Behalf of a Pennsylvania Woman Who Allegedly Sustained Multiple Arm Fractures Allegedly Due to Shape-Ups’ Defective
3. Wright Hip Implant Lawyers at Bernstein Liebhard LLP Note Scheduling of Next Status Conference in Federal Wright Conserve Hip Replacement Litigation
4. NuvaRing Lawsuit Filed on Behalf of a South Carolina Woman who Developed Two Blood Clots While Using NuvaRing, Reports Wright & Schulte LLC
5. Skechers Injury Lawsuit Filed on Behalf of an Alabama Man Who Suffered Severe Leg Fracture Allegedly Due to Skechers Shape-Ups Toning Shoes, by Wright & Schulte LLC
6. To feed the world, give women equal rights
7. Skechers Foot Fracture Lawsuit Filed on Behalf of Nevada Woman Who Suffered a Fracture Allegedly Due to Skechers Shape-Ups Toning Shoes, Reports Wright & Schulte LLC
8. Focal Upright Furniture Announces ErgoDepot as First Retail Partner
9. Dr. Farshchian to Interview Alisha Bright on "Arthritis Show"
10. Can Brightly Colored Fruits, Veggies Protect Against ALS?
11. Brightwater Senior Living of Stonebridge, Saskatoon's Newest Personal Care and Memory Care, Is Proud To Sponsor The Alzheimer Society of Saskatchewan's Walk For Memories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... ... “Ebola: In Praise of Prevention,” an animated video designed to prevent ... French translations of the video are being distributed throughout Togo, Liberia, Sierra Leone, ...
(Date:2/8/2016)... ... February 08, 2016 , ... CURE Media Group , the ... the Multiple Myeloma Heroes Awards event , which will annually honor individuals making ... patients with MM. The MM Heroes Awards nomination process is officially open ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Valentine’s Season is famous for gift giving with flowers, chocolates ... they are loved. This year, for more than 5.6 million Americans suffering with Alzheimer’s, ... be enough to remind them of the lives they’ve led and the people they’ve touched. ...
(Date:2/8/2016)... Hilton Head Island, SC (PRWEB) , ... February 08, 2016 , ... ... Head and surrounding areas with a vital new community enrichment program, has teamed up ... to local women and children suffering from intimate abuse. To support all those victimized ...
(Date:2/8/2016)... AUSTIN (PRWEB) , ... February 08, 2016 , ... Remember ... next time. , According to Perry A~, author of “Calcium Bentonite Clay” the ... a key role in balancing and detoxifying the body. , A former motivational speaker, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  Otsuka Pharmaceutical Co., ... that they have entered into a licensing agreement granting ... the U.S. and Puerto Rico . ... topical, non-steroidal phosphodiesterase IV (PDE-4) inhibitor, a new treatment ... --> In a Phase II clinical trial, ...
(Date:2/8/2016)... 2016  Echo Therapeutics, Inc. (Nasdaq: ... on non-invasive continuous glucose monitoring (CGM) and ... it will host a webcast and conference ... 9:00 a.m. Eastern Time to provide a ... advancements in its CGM system, and its ...
(Date:2/8/2016)... -- http://www.researchandmarkets.com/research/fqx6nz/global_skin ) has announced ... Equipment Market 2016-2020" report to their offering. ... announced the addition of the "Global Skin ... offering. --> Research and ... of the "Global Skin Protective Equipment Market ...
Breaking Medicine Technology: