Navigation Links
The protective milk shot
Date:5/23/2014

Antibodies against C. suis are transferred via the sow's very first milk to the piglets immediately after birth. This was discovered by veterinarian and parasitologist Lukas Schwarz and his colleagues in 2013. These findings prompted the researchers at the Institute for Parasitology to look for a way to increase the level of these antibodies in sows. The ultimate goal was to provide the piglets with as much antibodies as possible via their mother's milk during the first few days of life.

Piglets from infected mothers are healthier

The idea paid off. Piglets from infected sows suffered less from the infection than piglets from non-infected sows. Overall offspring from immunised mothers had less severe diarrhoea or no diarrhoea at all. Piglets that became ill recovered faster and excreted fewer parasites compared to those from non-immunised sows.

"An infection with Cystoisospora suis causes serious gastrointestinal disease in piglets. The infection is continues completely asymptomatic in adult pigs", explains lead author Schwarz.

Sows produce antibodies for their offspring

To stimulate antibody production against Cystoisospora suis in sows, researchers exposed pregnant sows to infectious stages (oocysts) of the parasite two weeks before parturition. Oocysts as the primarily infectious stage stick to the floor and other objects in the farrowing barns. Piglets ingest them and the parasite colonizes the gut, attacking the mucous membrane. The parasites multiply in the body before being excreted and the cycle starts again. Cystoisospora suis can survive in pigsties for a number of months and is very hard to kill. This leaves farmers faced with the likelihood of new infections. Sows also ingest the parasite, but due to age resistance they are not affected by this coccidian parasite.

High concentrations of antibodies against the parasites are passed on to the piglets in the first few hours of life through their mother's milk, where they enter the blood stream and the intestines of the newborns who cannot yet produce their own antibodies. These maternal antibodies protect the piglets from infections in the first few weeks of life. The higher the concentration of antibodies in the sow's milk, the better protected her offspring are.

More antibodies mean less diarrhoea

Piglets with milder symptoms showed higher concentrations of IgA in their blood. These immunoglobulins are not just in the bloodstream, they are primarily found on the surface of the mucous membranes including the intestines where they serve as a defence against pathogens. Researchers found equally high levels of IgA in the blood of the infected mothers. "To date it has been assumed that immunoglobulins do not play a role in the course of swine coccidiosis. Our results provide the first indications that immunoglobulins could actually be quite important. Additional studies are required to identify the exact role played by the antibodies", Schwarz explains.

Protective milk as the basis for a vaccine

Researchers found particularly high concentrations of IgA in the very first milk known as colostrum, a highly nutritious milk all mammals ingest during the first days of life. This form of "milk vaccination" might serve as a basis for developing an immunisation strategy to prevent swine coccidiosis.

"There are some effective medications for swine coccidiosis, but we would like to use the piglet's immune response to stop it in its tracks before the infection even gets started," lead author Lukas Schwarz concludes.

The importance of Cystoisospora suis

Neonatal porcine coccidiosis caused by Cystosisospora suis is a severe parasitic disease of the intestinal tract of neonatal piglets caused by the unicellular organism Cystoisospora suis. Coccidiosis is associated with extensive destruction of the gut mucosa and thus with reduced food conversion, causing decreased weight gain and economic losses for farmers. Infection with Cystoisospora suis results in heavy diarrhoea and may cause fatalities if secondary bacterial infections are present. For animal welfare considerations as well as for economic reasons there is considerable interest in trying to control the disease.


'/>"/>

Contact: Lukas Schwarz
lukas.schwarz@vetmeduni.ac.at
43-125-077-6848
University of Veterinary Medicine -- Vienna
Source:Eurekalert  

Related medicine news :

1. Protective Wear for Health-Care Workers Invented by InventHelp Client (CTO-279)
2. Strong state alcohol policies protective against binge drinking
3. Protective Clothing Market is Growing at a CAGR of 6.0% & to Reach $8 Billion by 2018 - New Report by MarketsandMarkets
4. Protective effects of dl-3n-butylphthalide against diffuse brain injury
5. Propofols effect on the sciatic nerve: Harmful or protective?
6. Pregnant rats exposed to obesity hormone lose births protective effect on breast cancer
7. Investigational malaria vaccine found safe and protective
8. Stryker Hip Lawsuit News: Bernstein Liebhard LLP Notes Issuance of Protective Order in New Jersey Stryker Hip Recall Litigation
9. Higher education may be protective against MS-associated cognitive deficits
10. Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Protective Order in Federal C.R. Bard Vaginal Mesh Litigation, Bernstein Liebhard LLP Reports
11. Study: Research reveals protective properties of influenza vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The protective milk shot
(Date:12/2/2016)... , ... December 02, 2016 , ... "Pro3rd Accents Volume ... editors to create versatile lower third titles with just a few clicks of the ... Volume 2 includes 30 lower third animations. Choose from various styles with accented animations, ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... to needy individuals and families from eight different sites throughout Miami-Dade and Broward ... Over 1,000 volunteers worked very hard on Thanksgiving morning by putting together individual ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... Laboratory Scientist & Author of Type 2 Diabetes: The Owner’s Manual, http://realtimepressrelease.com/press-releases-tagged-with/daryl-wein ... Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health radio ...
(Date:11/30/2016)... Massachusetts (PRWEB) , ... November 30, 2016 , ... ... proud to announce that we have been designated as a Cigna Infertility Center ... or exceed rigorous performance standards. , “It’s an honor to be designated ...
(Date:11/30/2016)... ... 30, 2016 , ... "I hate when the mixture of saliva and toothpaste ... an inventor from Bridgewater, N.J. "I thought that there had to be a way ... developed the patent-pending DEFLECTOR to prevent saliva and toothpaste from running down the brush ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... bioLytical Laboratories, ein Weltführer bei schnellen Tests für Infektionskrankheiten, hat sein ... eingeführt. Continue Reading ... ... , ... ) bioLytical wurde durch die Clinton Health Access ...
(Date:12/2/2016)... , Dec. 2, 2016   CytoSorbents Corporation ... commercializing its European Union approved CytoSorb ® cytokine ... surgery patients worldwide, announced that Dr. Phillip Chan ... 9th Annual LD Micro Main Event investor conference ... at the Luxe Sunset Boulevard Hotel in ...
(Date:12/2/2016)... LYME, Conn. , Dec. 1, 2016  Today, ... has announced the honor of being selected as winners ... include: Simpson Healthcare Executives Website at the PLATINUM level, ... Conversations Training Module at the GOLD Level, and our ... At Simpson Healthcare Executives, we are excited ...
Breaking Medicine Technology: