Navigation Links
The proof's in the bubbles
Date:3/1/2010

Reston, Va.An imaging technique combining ultrasound and specially modified contrast agents may allow researchers to noninvasively detect cancer and show its progression, according to research published in the March issue of The Journal of Nuclear Medicine (JNM). The technique enables researchers to visualize tumor activity at the molecular level.

"We hope this technique might be helpful for the early detection of disease," said Juergen K. Willmann, M.D., lead author of the study and assistant professor of radiology at Stanford University School of Medicine. "It may help save lives by finding cancersuch as breast, ovarian or pancreatic cancerin the very early stages, when it is still curable."

In the study, researchers intravenously injected microbubblesgas-filled spheres small enough to travel through vesselsinto mice with cancers. The microbubbles, which were paired with a new peptide (a molecule that consists of a chain of amino acids), were designed to travel through the vascular system and attach to integrina well-characterized molecular marker that acts as a "red flag" for tumor vessel growth, or angiogenesis. Tumor vessel growth occurs when active tumor cells create certain pathways to provide the tumor with a sufficient supply of oxygen, nutrients and other factors needed for growth.

Once the gas-filled microbubbles seek out the cancers and attach to their vessel walls, they send out strong signals that are picked up by standard clinical ultrasound scanners. The imaging signals produced by the microbubbles are reflected back to the ultrasound transducer and illuminate the areas that outline the tumor, thus providing researchers with a sonogram of tumor vessel growth on a molecular level.

"Ultrasound holds great promise for the application of molecular imaging because it is widely available, relatively inexpensive and safe. There is no exposure to radiation and repetitive imaging is not a concern," said Dr. Willmann. "Furthermore, the targeted microbubbles have great potential for translation from bench to bedsidewhich will be explored in future studies," said Sanjiv Gambhir, M.D., Ph.D., director of the molecular imaging program at Stanford.

Contrast-enhanced ultrasound can be used to image blood perfusion in organs, to measure blood flow rate in the heart and other organs and to perform other applicationssuch as characterization of focal lesions in the liver. Current interest is focused on modifying contrast agents to make them specifically useful for molecular imaging. The microbubbles, paired with the new peptide that binds to tumor vessel cells as studied in the current research, may be more effective than antibody molecules, which are time-intensive to produce, are costly and may cause adverse reactions in patients.

Noninvasive imaging strategies such as the one described in the JNM study may be particularly helpful for diagnosing cancer in its earliest stages as well as for developing therapeutic agents to treat cancer and monitoring whether treatment is working.


'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Cancer cells spread by releasing bubbles, according to an MUHC study
2. VIDEO from Medialink and Philips: Microbubbles Developed to Administer Medications That Fight Cancer and Reduce Side Effects
3. Im forever imploding bubbles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own ... others prefer to read it, and some people don't like it at all. FindaTopDoc ... what they found: , Erotic literature can give readers a taste of their deepest, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ensuring meat products have ... highlight the importance of correctly using a meat thermometer. The videos feature University ... research on consumer food safety habits. Dr. Bruhn explains the variety of meat ...
(Date:6/23/2017)... West Palm Beach, FL (PRWEB) , ... June 23, 2017 , ... ... June 19, in Pinecrest, Florida. This is MD Now’s 28th facility overall and marks ... 12301 S. Dixie Highway, located one mile North of The Falls shopping mall. The ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... American Farmer, ... winning series, which is slated to air fourth quarter 2017. American Farmer airs Tuesdays ... Hansen, a Danish pharmacist, founded Chr. Hansen in Denmark in 1874 after a ...
(Date:6/23/2017)... ... 23, 2017 , ... Jusino Insurance Services, a locally owned ... greater Chicago metropolitan area, is embarking on a charity drive in conjunction with ... Founded in 1897, Hephzibah Children’s Association is one of the oldest social services ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)...  NxStage Medical, Inc. (Nasdaq:  NXTM), a leading medical technology company ... demonstrating positive biochemical outcomes related to more frequent hemodialysis ... will be presented at the ERA-EDTA Congress being held ... . The research was conducted by ... Europe (KIHDNEy) Cohort team ...
(Date:5/30/2017)... TEL AVIV, Israel , May 30, 2017 /PRNewswire/ ... clinical stage pharmaceutical Company specializing in the development ... management will present a company overview at three ... The 7th Annual LD Micro Invitational: ... Date:                     ...
(Date:5/24/2017)... 2017  ivWatch LLC today announced the launch ... to enable seamless integration of ivWatch,s groundbreaking IV ... pumps and other devices. By integrating ivWatch technology ... help health care customers deliver a higher level ... IV therapy. "The ivWatch OEM Board ...
Breaking Medicine Technology: