Navigation Links
The profound effects of numbing agents
Date:12/11/2008

A large proteomics study on the brains of newborn mice provides more evidence that numbing drugs often used in obstetric or pediatric medicine can have profound and long-term negative effects, even after minimal exposure.

This study, appearing in the December issue of Molecular and Cellular Proteomics, highlights the delicate state of the developing nervous system and reinforces the use of caution when administering sedatives, anesthetics, and anti-convulsants to pregnant women or infants.

Compounds that either block excitatory NMDA receptors or activate inhibitory GABA receptors in the brain are clinically useful as anesthetics or for treating disorders like seizures and insomnia. However, just like other chemicals that produce similar mind-soothing effects (e.g. alcohol), excessive use can be detrimental particularly in still-developing individuals.

To examine how far-reaching the physiologic effects of such 'numbing' drugs (sedatives, hypnotics, analgesics) are, Angela Kaindl and colleagues treated 6-day old mice with two doses of either the NMDA receptor blocker dizocilpine or the GABA receptor activator Phenobarbital and then analyzed subsequent changes in brain protein expression.

They observed both acute and sustained effects, with protein changes in the cerebral cortex (the area controlling memory, thought, awareness, and language) evident after just 24 hours, and these changes were still present one week and one month after the one-day drug treatment. The affected proteins are involved in crucial processes like cell growth, cell death, and the formation of neural circuits (In another recent study, the authors were able to confirm that such drug treatment negatively influences learning and memory).

A similar drug dose given to adult mice did not produce such changes, which the authors note clearly shows how susceptible infant brains are compared to adults. Importantly, this study shows that drug overuse on even one occasion (for example, during the delivery procedure) can have long-term implications.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related medicine news :

1. Sugammadex Study First to Show Rapid Reversal of Profound Rocuronium-Induced Muscle Relaxation is Possible
2. New study may explain Vioxx side-effects
3. 13 percent of women stop taking breast cancer drug because of side effects, U-M study finds
4. Natural aorta grafts have few side effects for infection-prone patients
5. New Report: Dangerous Drug Side Effects and Deaths Doubled Since 1998... Seniors Hit Hardest
6. Detroit Metro Tower Air Traffic Controllers File Lawsuit Alleging Improper Mold Removal and Health Effects
7. Empowerment Program Gets Patients on the PATH to Managing the Physical and Emotional Effects of Psoriatic Arthritis
8. Shaking may cause brain damage and serious long-term effects to infants
9. Smoking can harm the long-term effects of some oral surgery procedures
10. ECLIPSE data on effects of Otsukas investigational novel treatment, Tolvaptan
11. Combination therapy reverses effects of portal hypertension in rats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... ... February 25, 2017 , ... The February 13, 2017, assassination of Kim Jong-nam, ... nerve agents and the deadly use of chemical weapons. Many questions exist about the ... small doses can be lethal. , Jay Jagannathan, M.D., of Michigan-based Jagannathan Neurosurgical Institute, ...
(Date:2/26/2017)... San Mateo, CA (PRWEB) , ... February 26, 2017 , ... ... Bay Area cities as diverse as Millbrae, Belmont, and Palo Alto, is proud to ... San Mateo. Many Bay Area consumers look for home care close to home, and ...
(Date:2/26/2017)... Overland Park, KS (PRWEB) , ... ... ... launch of StaffBridge sets a new technology standard in staffing, scheduling, and ... to manage, monitor, and predict activity throughout the entire staffing process. StaffBridge ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... (PD) in persons with a specific LRRK2 mutation, according to a study released ... studies have provided evidence of a link between pesticides and incidence of sporadic ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... tooth replacement options at his office, Antoine Dental Center. Currently, patients can get ... Some restrictions may apply, but patients can learn more about these offers by ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017 Medical information groups within the ... self-service capabilities to manage inquiries from external stakeholders ... New research from consulting leader Best Practices, LLC ... website portals where HCPs can sign on and ... many findings to emerge from the new study ...
(Date:2/24/2017)... -- Report analyzes the worldwide markets for Endodontic Supplies in ... US, Canada , Japan ... , Latin America , and Rest of ... 2015 through 2022. Also, a six-year historic analysis is provided ... primary and secondary research. Company profiles are primarily based on ...
(Date:2/24/2017)... -- Directors from Pharma To Market Pty Ltd and Ador Consulting Pte ... the founding of Pharma To Market Pte Ltd, based in ... to announce their expansion into Asia with ... The company are delighted to appoint Joelle Chia , former ... based entity. Joelle brings with her an extensive business ...
Breaking Medicine Technology: