Navigation Links
The prevention of hereditary breast and ovarian cancer by PGD is 'feasible'
Date:7/2/2012

Istanbul, 2 July 2012: Preimplantation genetic diagnosis (PGD) for the breast cancer genes BRCA1/2 is now feasible and established, with good success rates for those treated, according to investigators from the reproduction, oncology and genetics centres of the university hospitals of Maastricht and Brussels. The results follow a review of the largest number of PGD treatments for BRCA1/2 in Europe and were presented today at the annual meeting of ESHRE (European Society of Human Reproduction and Embryology) by Professor Willem Verpoest from the Centre for Reproductive Medicine at Vrije Universiteit Brussel, Belgium.

Behind his vote of confidence lie 145 PGD cycles for BRCA1/2 mutations performed in 70 couples at the two centres (a mean of 2.1 cycles per woman). Almost 60% of the mutation carriers were female, two-thirds with a BRCA1 mutation. Just over one quarter (26.2%) of female carriers had undergone a prophylactic bilateral mastectomy.

Following IVF, 717 embryos were found suitable for genetic analysis, and of these 43.1% were diagnosed as affected by the mutation, with 40.7% unaffected and thus suitable for transfer (the remainder had an abnormal genotype or the analysis was inconclusive). Hence, 62.1% of the PGD cycles led to fresh embryo transfer - with 3.6% transferred from one or two frozen-thawed unaffected embryos - resulting in 42 pregnancies in 40 women. Pregnancy rates were 41.4% per fresh embryo transfer and 23.1% per frozen. The overall pregnancy rate was 29%.

The series also included three cases of PGD on embryos previously cryopreserved for fertility preservation prior to chemotherapy, and these too resulted in two ongoing pregnancies.

Two female BRCA1 carriers were diagnosed with breast cancer within three months of the PGD treatment, despite breast screening shortly before treatment. One had a history of breast cancer, the other patient hadn't. The former patient went on to have healthy twins three years
'/>"/>

Contact: Christine Bauquis
christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
2. Researchers call for obesity prevention efforts to focus on community-wide systems
3. HIV prevention measures must include behavioral strategies to work, says APA
4. New guidelines deliver concise messages for implementing cardiovascular prevention
5. Better health in adulthood starts with early prevention in childhood
6. Supplements and cancer prevention: A cautionary tale
7. Cyberbullying May Call for New Prevention Tactics
8. Animated characters keep it real in teen violence prevention videos
9. Report outlines successes, challenges in cancer prevention efforts
10. HIV Prevention Pill Cost-Effective for High-Risk Men: Study
11. Decision guide reduced uncertainty over breast cancer prevention, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... Angeles, CA (PRWEB) April 21, 2015 ... power score of 3.8 out of 5, indicating generally ... due to its low barriers to entry and the ... are only moved relatively short distances,” says IBISWorld research ... scattered throughout the country, typically serving local and regional ...
(Date:4/21/2015)... 21, 2015 As nationally recognized ... in various components of breast reconstruction research spanning ... , "Breast reconstruction research continues to significantly contribute ... recent advances, many unanswered questions remain requiring continuous ... optimal results," says Dr. Oscar Ochoa emphasizing the ...
(Date:4/21/2015)... The Northeast Football Clinic (NEFC) has ... prep school in Byfield, MA. Applications are being accepted ... entering grades 6-12. , The outstanding professional, college, and ... coaching. , Offensive and defensive linemen and ... the most unsung positions on the field, the the ...
(Date:4/21/2015)... 2015 Freeslate, Inc ., the ... today announced that the Centre for Catalysis Research ... has acquired a Freeslate Core Module 3 (CM3) ... (SPR) to accelerate current research programs. The systems ... they will be available to academic users and industrial ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 This ... pathologists, physical therapist assistants, occupational therapist assistants, teachers, ... and techniques to help children across the autism ... through Education Resources Inc. , ... 2008, this highly acclaimed yoga curriculum addresses learning ...
Breaking Medicine News(10 mins):Health News:Bulk Food-Grade Transportation Services Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Bulk Food-Grade Transportation Services Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Research Performed at PRMA Expands Breast Reconstruction Knowledge 2Health News:Research Performed at PRMA Expands Breast Reconstruction Knowledge 3Health News:Research Performed at PRMA Expands Breast Reconstruction Knowledge 4Health News:Research Performed at PRMA Expands Breast Reconstruction Knowledge 5Health News:US Sports Camps and The Northeast Football Clinic Announce 2015 Lineman/Linebacker Clinic Schedule 2Health News:University of Ottawa Selects Freeslate Reaction Screening System to Support High-Throughput Research at the Centre for Catalysis Research and Innovation 2Health News:University of Ottawa Selects Freeslate Reaction Screening System to Support High-Throughput Research at the Centre for Catalysis Research and Innovation 3Health News:ABC News Interviews Anne Buckley-Reen, Education Resources Inc. Faculty Member, on Yoga Therapy in the Classroom 2
... and pediatricians have relied on humid air to relieve the ... condition that sometimes// sends worried families to the emergency room. ... relied-on remedy has little medical benefit. ,“Typically you ... the bathroom. Or you get them to boil a kettle ...
... by most major medical associations, including the American Academy of ... , More than nine in 10 doctors who are taught ... consideration before circumcising a baby boy; compared with only seven ... survey shows that 97 percent of these doctors now learn ...
... IV antibiotic that can be used for the treatment ... by antibiotic// resistant bacteria such as methicillin-resistant Staphylococcus aureus ... today. Availability of this new antibiotic comes at a ... greater than ever and clinicians are running out of ...
... Meeting of SNM in San Diego witnessed a meeting ... imaging and nuclear medicine branch// and this meeting was ... ,“SNM continues to successfully offer a unique ... new and evolving aspects of nuclear medicine and molecular ...
... from the civic hospitals on Friday have indicated that ... and other rain-related ailments,// taking the death toll in ... officials have claimed that additional precautions have been taken ... including Kurla and parts of Malad. The earlier reports ...
... is being launched in Australia to help men manage ... so that men who are diagnosed// every year have ... (NBCC) maintains the website. ,It was explained ... with the condition. Alison Evans, from the National Breast ...
Cached Medicine News:Health News:Humid Air is Little Help for Croup's Barking Cough 2Health News:Humid Air is Little Help for Croup's Barking Cough 3Health News:Pain Relief During Circumcision 2Health News:Broad Spectrum Antibiotic Available for Antibiotic Resistant Bacteria 2Health News:SNM recognizes exemplary contributors in nuclear medicine 2Health News:Monsoon Related Diseases On The Rise In Mumbai 2
(Date:4/20/2015)... , April 20, 2015  Sigma-Aldrich Corporation ... Corporate Responsibility (CR) Magazine,s list of the 100 ... on outstanding corporate responsibility performance.  Sigma-Aldrich ranked fifth, ... appearance on the list. "We are ... corporate responsibility efforts and we are extremely pleased ...
(Date:4/20/2015)... The preclinical contract research organization Absorption Systems ... safety testing of medical devices, announces that its Chief Scientist, ... " Drug Transporters in ADME: From the Bench to the ... title of Dr. Hidalgo,s talk is "Modern Tools for the ... Tools of the Future." The workshop, organized jointly ...
(Date:4/20/2015)...  Ameritox,s Ingenuity Health, a leading provider of monitoring ... at the National Council of Behavioral Health annual conference ... nearly 25 percent of the samples collected from patients ... prescribed antipsychotic medication. ... Medication nonadherence ...
Breaking Medicine Technology:Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2Absorption Systems Chief Scientist Ismael Hidalgo to Present at International Workshop on Drug Transporters 2Ingenuity Health Research Flags Potentially High Rate of Medication Nonadherence Among Those with Serious Mental Illness 2Ingenuity Health Research Flags Potentially High Rate of Medication Nonadherence Among Those with Serious Mental Illness 3
... FOREST, Ill., April 11, 2011 PharMEDium Healthcare Corporation ... of Anesthesiologists (ASA), as a part of a new ... practice management companies. David N. Jonas, PharMEDium ... ASA,s efforts to advance the anesthesiology field through leadership, ...
... In response to Thursday,s Medicare Payment Advisory ... substantially higher levels of advanced diagnostic imaging services ... approval before being able to provide those services, ... instead look to existing clinical decision support tools ...
Cached Medicine Technology:PharMEDium Becomes a Corporate Supporter of the American Society of Anesthesiologists (ASA) 2Healthcare Providers, Technology Experts Call for Use of Existing Decision Support Tools to Promote Diagnostic Imaging Appropriate Use 2Healthcare Providers, Technology Experts Call for Use of Existing Decision Support Tools to Promote Diagnostic Imaging Appropriate Use 3
... Centuries of German Craftsmanship ... instrumentation in the world. Ocutek® ... you! Only holders of the ... and eight-year apprenticeship, are qualified ...
... Endoscopic CycloPhotocoagulation (ECP) is a surgical ... endoscopy and visualized laser application. The ciliary ... by the surgeon, from the anterior or ... time. The target tissues are easily and ...
... a surgical approach to glaucoma management that ... The ciliary body (which produces aqueous humour) ... anterior or posterior segment, through the endoscope ... easily and accurately identified utilizing endoscopy. This ...
... (ECP) is a surgical approach to glaucoma ... laser application. The ciliary body (which produces ... from the anterior or posterior segment, through ... tissues are easily and accurately identified utilizing ...
Medicine Products: