Navigation Links
The prevalence of hepatitis B virus infection in inflammatory bowel disease patients
Date:9/17/2008

Patients with IBD have high risk of infection by hepatitis viruses B or C because during the course of their disease, they need blood transfusions, and sometimes surgical and endoscopic procedures for diagnosis and treatment. It is important to alert health professionals about prevention and early diagnosis of HBV infection because the steroids and immunosuppressant drugs used in IBD treatment worsen the HBV liver disease. Few studies exist to verify if these drugs influence HBV infection in IBD patients.

A research article to be published on 28 May 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Yolanda Faia Manhes Tolentino from Federal University of Rio de Janeiro evaluated the prevalence of HBV infection in IBD patients that followed up in the hospital and the possible risk factors involved in HBV infection transmission in the patients group.

It was a cross-sectional study for which 176 patients were selected according to their arrival for the medical interview. All those patients had already IBD diagnosis. The patient was interviewed and a questionnaire was filled out.

It was concluded that there was a high incidence of positive anti-HBc (17%) and positive HBsAg (2.3%) in IBD patient when compared with the overall population (7.9%).

The statistical analysis couldn't identify one possible risk factor for HBV transmission but the study found among the IBD patients 4 persons with positive HBsAg that was called inactive bearers. Studies show that immunological supression caused by steroids, immunosupressants drugs and the anti-TNF (anti necrosis antibodies - Infliximab) in IBD patients can influence the course of hepatic disease once used in HBsAg positive patients. Those drugs would take a viral replication and infection spread inside hepatocytes. It has already been related 1 case of hepatic insufficiency and death in a Crohn's disease (CD) patient and 1 case of fulminant hepatitis in rheumatoid arthritis patient both with positive HBsAg and treated with these drugs. In patients with positive HBsAg, it would be recommended the lamivudine use before immunological suppression.

After this study, it was recommended HBV vaccination for IBD patients that have never been infected by BV and also recommend lamivudine for patients with positive anti-HBc and needs to use steroids and immunomodulators.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Prevalence of COPD Greater Than Thought
2. A low prevalence of H pylori in HIV-positive patients
3. Asymptomatic peripheral artery disease prevalence is rising
4. CDC Reports Prevalence of Worms Transmitted by Dogs and Cats to Humans is Higher Than Previously Understood
5. Miscarriage myths persist despite prevalence of medical information
6. The prevalence and impact of arthritis and other rheumatic conditions in the United States
7. Painful Sex in Women: Studies Show High Prevalence, but New Hope
8. APIC launches first national C. difficile prevalence study
9. APIC Launches First National C. Difficile Prevalence Study
10. Prevalence of pre-cancerous masses in the colon same in patients in their 40s and 50s
11. Researchers uncover higher prevalence of periodontal disease in rheumatoid arthritis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... 25, 2016 , ... Extremity Healthcare, Incorporated has implemented Phreesia ... check-in and post visit surveys. , “The Phreesia front desk system has already ... the check-in process for our clinic network, providing a world class administration system ...
(Date:5/25/2016)... ... May 25, 2016 , ... A new update to ... motion capture, all by utilizing a common Wi-Fi network and a mobile device. When ... from any location with Wi-Fi, and use a mobile device to control the recording. ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... (KOHP), a $500,000 two-year pilot initiative to improve oral health-related awareness, education, prevention ... development for health care providers and promote best practices in 10 New Jersey ...
(Date:5/25/2016)... ... May 25, 2016 , ... Today American University ... College of Medicine announced the AUA-FIU Global MD Program. Students in the ... from AUA and a Certificate of Completion from the FIU Herbert Wertheim College ...
(Date:5/25/2016)... ... ... Today Omega Institute, a leading destination for yoga education in New York’s Hudson ... the growing field of yoga therapy . Yoga therapy adapts the practice of ... injuries, illnesses, and temporary or chronic health conditions. , “Yoga therapy is a complementary ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... -- Een app die artsen over de ... kunnen behandelen, hun kennis kunnen delen en van elkaar ... en revolutionaire MDLinking App, ontwikkeld door een internationale groep ... Flu en oncologisch chirurg dr. Gijs van Acker ... op dinsdag 24 mei officieel gepresenteerd op het Amsterdam ...
(Date:5/23/2016)... 23, 2016 Transparency Market Research ... Pancreatic Insufficiency Market - Global Industry Analysis, Size, Share, ... to the report, the exocrine pancreatic insufficiency market is ... 2015 to 2023 to reach US$2.85 Bn by 2023. ... characterized by the deficiency of the exocrine pancreatic enzymes, ...
(Date:5/23/2016)... 23, 2016 Non-invasive diagnostic test ... multiple diseases; ,Technology to be presented at Yissum’s booth, ... Research Development Company of the Hebrew University of Jerusalem ... agreement with Aurum Ventures MKI, the technology investment arm of ... new diagnostic approach for early detection of multiple diseases ...
Breaking Medicine Technology: