Navigation Links
The prevalence of gluten-sensitive enteropathy in iron-deficient anemia patients
Date:12/31/2008

Gluten sensitive enteropathy (GSE) is an autoimmune enteropathy due to food gluten intolerance in genetically predisposed people. While GSE was thought to be a rare disease in the past and was believed to be essentially a disease of Europeans, recent screening studies showed that GSE is one of the most frequent genetically based diseases occured worldwide. Iron deficiency anemia could be a sole manifestation of GSE, and it might result in the delayed diagnosis of GSE, resulting in complications.

A research team led by Prof. Reza Malekzadeh studied the prevalence of gluten sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. Their findings will be published on December 28, 2008 in the World Journal of Gastroenterology.

In this prospective study, 4120 patients with IDA were enrolled in this study. Anti-endomysial antibody (EMA) and tissue transglutaminase antibody (tTG) levels were evaluated and duodenal biopsies were taken and scored according to the Marsh classification. The diagnosis of GSE was based on a positive serological test and abnormal duodenal histology. Gluten free diet (GFD) was advised for all the GSE patients.

Of the 4 120 IDA patients, 206 (95 male) patients were found to have IDA of obscure origin. Thirty out of 206 patients (14.6%) had GSE. Sixteen patients had Marsh 3, 12 had Marsh 2, and 2 had Marsh 1 lesions. The severity of anemia was in parallel with the severity of duodenal lesions. Twenty-two GSE patients (73.3%) had no gastrointestinal symptoms. Fourteen GSE patients who adhered to GFD without receiving iron supplementation agreed to undergo follow up visits. After 6 mo of GFD, their mean hemoglobin levels (Hb) increased from 9.9 1.6 to 12.8 1.0 g/dL (P < 0.01). Interestingly, in 6 out of 14 patients who had Marsh 1/2 lesions on duodenal biopsy, mean Hb increased from 11.0 1.1 to 13.1 1.0 g/dL (P < 0.01) while they did not receive any iron supplementation. These results indicate that there is a high prevalence of GSE in patients with IDA of obscure origin. Gluten free diet can improve anemia in GSE patients who have mild duodenal lesions without villous atrophy.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. The prevalence of hepatitis B virus infection in inflammatory bowel disease patients
2. Prevalence of dementia in the developing world underestimated
3. Prevalence of US osteoprotic hip fracture hospitalizations declines despite an aging population
4. Researchers uncover higher prevalence of periodontal disease in rheumatoid arthritis patients
5. Prevalence of pre-cancerous masses in the colon same in patients in their 40s and 50s
6. APIC Launches First National C. Difficile Prevalence Study
7. APIC launches first national C. difficile prevalence study
8. Painful Sex in Women: Studies Show High Prevalence, but New Hope
9. The prevalence and impact of arthritis and other rheumatic conditions in the United States
10. Miscarriage myths persist despite prevalence of medical information
11. CDC Reports Prevalence of Worms Transmitted by Dogs and Cats to Humans is Higher Than Previously Understood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... , ... On Sunday, September 24, hundreds will gather at Flo Jo Park ... the fastest woman of all time. Flo Jo passed away from complications related ... National Anthem. Mary was a contestant on the 2012 season of America’s Got ...
(Date:9/22/2017)... ... September 22, 2017 , ... Fenwick Agency of Plano, TX has announced the ... part of the nationally recognized ‘Agents of Change’ movement. The agency pledges to select ... leaders to seek out those who most need help. Their hope is to bring ...
(Date:9/22/2017)... ... September 22, 2017 , ... After ... a senior finds a new lease on life with assistance from CreditAssociates. CreditAssociates ... resolve their problem with unsecured debt. The senior is one of the satisfied ...
(Date:9/22/2017)... , ... September 22, 2017 , ... ... SABRE Safe Is Smart Scholarship Sweepstakes.,  , Molli C., a graduate student from ... in Educational Leadership and Administration at St. Thomas University in Miami, Florida, was ...
(Date:9/22/2017)... IL (PRWEB) , ... September 22, 2017 , ... Pullano ... attorney Richard L. Pullano has been selected to serve as President of ... 50th President at the Installation and Award Dinner hosted by the NSBA at the ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 6, 2017 Eli Lilly and Company (NYSE: ... new data for galcanezumab and lasmiditan, two investigational treatments ... Headache Society (IHC) taking place Sept. 7-10 in ... highlight new, long-term data from an open-label study evaluating ... (120 mg and 240 mg) for the prevention of ...
(Date:9/5/2017)... , Sept. 5, 2017  Just 18 months ... Insight is pleased to announce the appointment of three ... Tammy Wynne , Dominic Jones-Phillips and ... industry. Tammy ... team of market access writers. She has over ten ...
(Date:9/1/2017)... , Sept. 1, 2017  Bayer will present the latest ... Society for Medical Oncology (ESMO) 2017 Congress, September 8-12 in ... include new preclinical and clinical data on Bayer,s marketed portfolio ... pipeline projects. "We ... minds in cancer research at ESMO," said Carsten Brunn ...
Breaking Medicine Technology: