Navigation Links
The pericyte becomes a player in Alzheimer's, other diseases
Date:11/17/2010

Cells in the brain called pericytes that have not been high on the list of targets for treating diseases like Alzheimer's may play a more crucial role in the development of neurodegenerative diseases than has been realized.

The findings, published Nov. 4 in Neuron, cast the pericyte in a surprising new role as a key player shaping blood flow in the brain and protecting sensitive brain tissue from harmful substances. By manipulating pericyte levels, scientists were able to re-create in the brains of mice an array of abnormalities that mirror in striking fashion the brain difficulties that occur in many people as they age.

"For 150 years these cells have been known to exist in the brain, but we haven't known exactly what they are doing in adults," said Berislav Zlokovic, M.D., Ph.D., the neuroscientist who led the research at the University of Rochester Medical Center. "It turns out that pericytes are very important for helping maintain a brain environment crucial to the health of neurons. The pericyte offers us an exciting new target for new treatments for neurodegenerative diseases."

While damage to neurons oftentimes causes the symptoms that patients experience dementia in Alzheimer's, and movement difficulties in Parkinson's disease, for instance neuroscientists know that neurons depend on a broad variety of factors coming together to create just the right environment to thrive. Zlokovic himself has pioneered the concept that impaired blood flow and flaws in the blood-brain barrier may play a huge role in the development of diseases like Alzheimer's through their impact on neurons.

In the most recent findings from Zlokovic's laboratory, the two first authors who contributed equally to the research, graduate student Robert Bell and M.D./Ph.D. student Ethan Winkler, teased out the role of the pericyte in the process. Pericytes ensheath the smallest blood vessels in the brain, wrapping around capillaries like ivy wrap
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. When climate change becomes a health issue, are people more likely to listen?
2. North Shore-LIJ Becomes NY's First Health System to Require New Nurses to Get Bachelor's Degree
3. TowerStrides Inc. Becomes Oracle PartnerNetwork Gold Level Partner
4. Pet Insurance from Trupanion Becomes Available in Hawaii
5. Mercy Ships Releases Abel Dalome Just in Time for Father's Day - A Father's Dream Becomes a Reality
6. Dubai Podiatry Centre Becomes the Gulf Region's First Clinic to Bring Apple iPads to the Healthcare Field
7. Scientist Becomes First Human Infected With Computer Virus
8. Houston Northwest Medical Center Becomes First Hospital in the Southwest Region Designated a Community of Respect™ Partner
9. CAP Becomes IHE Laboratory Domain Sponsoring Organization
10. InPro Becomes AAHID Industry Partner
11. Glidewell Dental Lab Becomes Exclusive U.S. Distributor of aveoTSD Anti-Snoring Device
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014 (HealthDay News) -- The United States is ... Ebola-affected nations of West Africa land at one ... infection with the virus. In a statement ... that 94 percent of air passengers from Guinea, ... of these five airports -- New York City,s ...
(Date:10/22/2014)... Grants Pass, OR (PRWEB) October 22, 2014 ... while Southern California’s fresh water supply runs dangerously low, ... climate change. Southern Oregon’s rivers, despite the lowest mountain ... fast even in late summer and early autumn.* That ... Urness, authors of the new book “Hiking Southern Oregon,” ...
(Date:10/22/2014)... Lintelus, Inc., an event software provider, ... Sales, will be speaking on the subject of “Event ... October 28, at the Holiday Inn in New York ... well as a Tech Demo at 12:45pm, to educate ... more engaging event experience. , The Annual Meetings Technology ...
(Date:10/22/2014)... TUESDAY, Oct. 21, 2014 (HealthDay News) -- Two sisters ... and heart damage. Ilina and Medha Krishen use ... for sounds of trouble in breathing patterns or heartbeats. ... School in Michigan, wanted to find a way to ... air pollutants. Using an electronic stethoscope, Ilina recorded one ...
(Date:10/22/2014)... By Dennis Thompson HealthDay ... freelance cameraman who was diagnosed with Ebola while working for ... system and can leave the special isolation unit at Nebraska Medical ... two weeks, the hospital said Tuesday. A blood test confirmed ... Ashoka Mukpo, 33, can head home to Providence, R.I., NBC ...
Breaking Medicine News(10 mins):Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3
... The hair-like protrusions of bacteria have a sticky protein on ... of these protrusions are in the form of a coiled// ... tightly, even through rough fluid flow inside the body, researchers ... group of researchers at the University of Washington in Seattle ...
... by Karolinska Institutet in Sweden and Makerere University in Uganda ... pregnant women// and this is the reason for pregnant women ... is the worst of the four malaria parasites that infect ... the placenta of pregnant women, with fatal consequences for both ...
... HIV/AIDS in the Northeast say that the media is insensitive ... to them// . ,"I have come across ... from me, and didn't even look at my eyes during ... the stigma," said Vanlalmuana, the president of the Positive Network ...
... indirect costs, the financial burden on a woman who has ... $1 million during her lifetime// . But even a woman ... condition to take a toll in the neighborhood of $800,000, ... M.D., medical director of the Preventive and Rehabilitative Cardiac Center ...
... which provided stem cell therapy for her multiple sclerosis. She ... and her illness has not improved. ,Speaking to ... to where I was before the treatment. It's quite gutting ... to work and it didn't. I spoke to the doctor ...
... of death almost three times pronounced for women undergoing ... , ,Catherine Deneux-Tharaux, M.D., M.P.H., of Hospital ... either during or within a month after delivery, were ... a vaginal delivery; irrespective of whether the caesarian was ...
Cached Medicine News:Health News:Fimbriae Help Bacteria Stick Around Inside the Body 2Health News:Malarial Parasite Hides In Placenta 2Health News:Study Says Chest Pain Toll in Women is More than Physical 2Health News:Study Says Chest Pain Toll in Women is More than Physical 3
(Date:10/22/2014)... , Oct. 22, 2014  With a vision ... health medications, a Global Pharmaceutical and Biotech manufacturer ... technology and turnkey solution to protect their animal ... http://photos.prnewswire.com/prnh/20141021/153438 Photo - ... was serialized and aggregated by the Xyntek and ...
(Date:10/22/2014)... 2014   BioNano Genomics , the genome ... centers to purchase an Irys™ System . Among ... Institute (NCI), NIH Intramural Sequencing Center (NISC) and Genoscope ... a comprehensive view of a genome was a ... not deliver the scalability or reliability to detect ...
(Date:10/22/2014)... Abaxis, Inc. (NasdaqGS: ABAX ), ... today reported financial results for the second fiscal quarter ... , Revenues of $53.9 million, up 18% over ... $0.24, up 33% over last year,s comparable quarter. ... Veterinary Reference Laboratories (AVRL) of $3.5 million, up 50% ...
Breaking Medicine Technology:Xyntek and Antares Serialization Solution Protects Pets Too! 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 4Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 5Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 6Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 7Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 8Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 9Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 10Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 11Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 12Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 13Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 14
... and local dignitaries ushered in a new chapter in ... of a laboratory complex designed to speed up cures ... housing 78 labs and other facilities, signifies a break ... different fields and allowing them to communicate more effectively. ...
... Sanofi Pasteur, the vaccines division of Sanofi (EURONEXT: SAN ... a new study examining the immunogenicity and safety profiles of ... and younger adults to a standard dose of Fluzone vaccine. ... the Infectious Diseases Society of America on October 21, 2011. ...
Cached Medicine Technology:MUSC Dedicates New Bioengineering and Drug Discovery Hubs 2Sanofi Pasteur Presents New Data Confirming Fluzone® High-Dose (Influenza Virus Vaccine) Produces Higher Antibody Response in the Age 65+ Population 2Sanofi Pasteur Presents New Data Confirming Fluzone® High-Dose (Influenza Virus Vaccine) Produces Higher Antibody Response in the Age 65+ Population 3Sanofi Pasteur Presents New Data Confirming Fluzone® High-Dose (Influenza Virus Vaccine) Produces Higher Antibody Response in the Age 65+ Population 4Sanofi Pasteur Presents New Data Confirming Fluzone® High-Dose (Influenza Virus Vaccine) Produces Higher Antibody Response in the Age 65+ Population 5Sanofi Pasteur Presents New Data Confirming Fluzone® High-Dose (Influenza Virus Vaccine) Produces Higher Antibody Response in the Age 65+ Population 6
... Microvolume technology , The ADVIA 1650 has ... as 2 L/test), reagent consumption (as low ... L/hour) - thus maximizing management efficiency. , ... cycle and system throughput of up to ...
... and controls interchangeable with other Roche/Hitachi ... training costs. Consistent patient results throughout ... handling. 70 positions for routine, STAT ... volumes. Intermix sample types. Intermix 5 ...
With the sample processing core unit and intelligent process management, combines a wide variety of analytical modules to enable full consolidation of clinical chemistry and immunochemistry....
... The Roche Diagnostics Task ... a state-of-the-art automation of ... the laboratories: decapping, sorting / ... aliquoting into bar code labeled ...
Medicine Products: