Navigation Links
The new source of islet cells
Date:10/25/2007

The shortage of islet cells limits the development of islet transplantation. One new approach was reported in the October 21 issue of the World Journal of Gastroenterology because of its great significance in enhancing the output of islet cells. This article will undoubtedly bring benefit to diabetic patients.

The article describes the differentiation of rat pancreatic ductal epithelial cells into insulin-producing cells by the transfection of PDX-1. In recent years, though great efforts have been made to differentiate embryonic stem cells, pancreatic ductal epithelial multipotent progenitor cells and bone marrow stem cells into islet cells, the process of cell differentiation and growth is long. Moreover, the amount of islet cells of differentiation, and the insulin released by islets, is not enough to meet the clinical needs.

To shorten the process of differentiation and enhance the output of insulin-producing cells and increase the amount of insulin-releasing, Dr Liu et al. transfected PDX-1 into primary pancreatic ductal epithelial cells and then differentiated the transfected cells into insulin-producing cells. In contrast, the expression of PDX-1 and insulin mRNA and protein were detectable in the transfected cells. Endogenous PDX-1 might play an important role during differentiation and the transfected cells can produce more insulin-releasing cells and release more insulin after induction.

The results of this study suggest a promising future for many diabetic patients who need islets transplantation. Due to the high percentage of diabetes mellitus and severe complications around the world, this case reported by Dr. Liu et al. is surely worth the attention of the researchers of diabetes.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Startling Expose – Physicians Often Have No Regular Source Of Health Car
2. Indian Cherry: Richest Source of Vitiamin C
3. Stem cells - New and richer source found
4. Platelets May Be The Source Of Gene Regulations
5. Walnuts a source of the Anti –oxidant Hormone Melatoni
6. Mushroom found to be a source of a new antibiotic: Plectasin
7. Urban Monkeys Source Of Virus Infections
8. Parents – Teen’s Most Reliable Source for Sex Educatin
9. Singapore’s Healthcare To Outsource To Indian Firm For Faster X-Ray Result
10. ADB To Provide Resources For Combating Bird Flu
11. Investigation to identify the source of HIV infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... ... May 26, 2016- In search of the K. Warriors, Shaolin Institute is ... Warriors” on June 4, 2016 at Ashbury Hotel and Suites 600 West Interstate 65 ... by Shaolin Institute and sanctioned by KSF (Kungfu Sanda Federation), This is the 28th ...
(Date:5/27/2016)... ... May 27, 2016 , ... Two director-level employees of Horizon ... to Women and Industry (TWIN) 2016 honorees. The award recognizes businesswomen who excel ... year, Geri Boone, Director of the MLTSS (Managed Long-Term Services and Supports) Program at ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities and thought ... industry, from leading advocates, associations and industry leaders such as Bioness. , ...
(Date:5/27/2016)... PALMYRA, Wis. (PRWEB) , ... May 27, 2016 ... ... over $90,000 in scholarships to students studying complementary medicine. Allison Outerbridge is this ... She accepted her award on May 18 at the university’s Student Leadership Awards ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, Pfizer, and 3M ... to court documents and SEC filings. A jury has returned a verdict ... Optical Corporation, Case No. BC588866, Los Angeles County, California. The jury awarded $22.8 ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... biopharmaceutical company focused on late-stage drug development, today ... Pharma of pivotal batches required for registration ... Administration (FDA). This follows Kitov,s announcement ... trial successfully met its primary efficacy endpoint. ...
(Date:5/26/2016)... May 26, 2016 TARE ... Both Cost Savings and Overall Decreased Use ... BTG), an international specialist healthcare company, has today ... 21st Annual Meeting of ISPOR (International Society for ... hepatocellular carcinoma (HCC) using yttrium-90 glass microspheres is ...
(Date:5/25/2016)... GERMANTOWN, Maryland , May 25, 2016 /PRNewswire/ ... dringenden Bedarf zur Steuerung ... N.V. (NASDAQ: QGEN ; Frankfurt Prime ... Entwicklungsvereinbarung mit Therawis Diagnostics GmbH zur Entwicklung und ... sein. Ein erstes Projekt wird die Entwicklung und ...
Breaking Medicine Technology: