Navigation Links
The nanomechanical signature of breast cancer
Date:2/1/2013

Philadelphia, Pa. The texture of breast cancer tissue differs from that of healthy tissue. Using a cutting-edge tissue diagnostic device, a group of researchers in Basel, Switzerland, has determined one key difference: cancerous tissue is a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This new finding may one day help improve breast cancer diagnosis and therapy by providing a unique nanomechanical signature of tumor tissue properties that indicates the potential for the cancer to spread. The team will present its work at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

"It is slowly being recognized that a key to the cancer problem lies in the physical properties of the tumor tissue and that biomechanics plays a key role in cancer cell migration, invasion, and metastasis," explains Marija Plodinec of the University of Basel in Switzerland. However, contradictory opinions persist about tissue texture, and the information is hard to get at cellular mechanics happen at the nanoscale, 1-100 millionths of a meter. This research may help resolve the controversy.

To determine stiffness, the team applied a nanoscale microscope tip to a breast tissue biopsy to make an indentation, then visualized and measured the indentation with an indentation-type atomic force microscope, which provides unprecedented spatial resolution. "The most significant outcome of our measurements is determining that in healthy tissue the stiffness of the sample is homogeneous," Plodinec says. "Benign tissue exhibits a larger variability and malignant tissue shows a unique, very heterogeneous profile with soft and stiff parts alternating."

A key aspect of their experiment is the adaptation of atomic force microscopy to rapidly collect and correlate nanoscale stiffness measurements across entire biopsy samples. They used a device called ARTIDIS ("Automated and Reliable Tissue Diagnostics"), invented by Plodinec and colleagues Marko Loparic and Roderick Lim. Partnering with industry, their next step is to develop ARTIDIS into an easy-to-use device for clinical application, hopefully within two years.

"A critical advantage of ARTIDIS technology, as we see it, is that it provides an estimate of tumor aggressiveness and metastatic spread based on the unique nanomechanical signature," Plodinec says. "This signature may have potential prognostic and predictive value as a marker for therapeutic applications."


'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers validate molecular signature to predict radiation therapy benefit
2. URMC researchers connect new genetic signature to leukemia
3. Moffitt researchers identify unique immune gene signature across thousands of patients solid tumors
4. ABC Home & Commercial Services’ Houston Branch Now Offering Discount on Initial Service with Signature Rodent Agreement
5. Personal epigenetic signatures found consistent in prostate cancer patients metastases
6. The Tampa Signature Massage Center Announces Couples Massage Awareness Month
7. Eliminating the good cholesterol receptor may fight breast cancer
8. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
9. Researchers develop a new cell and animal model of inflammatory breast cancer
10. Scientists uncover multiple faces of deadly breast cancer
11. Depo-Provera Birth Control Might Raise Breast Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... TopConsumerReviews.com recently ... Lab Testing . , The healthcare industry in the United States has undergone ... are the days of needing to have a doctor’s order to get a blood ...
(Date:8/16/2017)... Petaluma, CA (PRWEB) , ... August 16, 2017 ... ... donate and distribute $100,000 in AED (Automated External Defibrillator) machines to their local ... an AED device from Arrow Benefits Group. AED machines are an integral part ...
(Date:8/16/2017)... ... ... of A Child” is the creation of published author, Pauline DiBenedetto. , “As my mother ... was in such great pain, my mother thought that her time has come. Once I ... I was about eight years old, when I had a vision of my own, that ...
(Date:8/15/2017)... Los Angeles, CA (PRWEB) , ... August 15, 2017 , ... The city of Los ... styles exist in harmony with “Cali Style”. LA’s Top Style List, a website that spotlights ... to help the public wear their wardrobe all year long. , According to the senior ...
(Date:8/15/2017)... ... August 15, 2017 , ... The V Foundation ... 19th Annual V Foundation Wine Celebration raised nearly $9 million for cancer research ... million in “Fund-A-Need” donations to support the study of BRCA mutation research in ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... WARSAW, Ind., July 27, 2017  Zimmer Biomet Holdings, ... the quarter ended June 30, 2017.  The Company reported ... of 1.1% over the prior year period, and an ... approximately 240 basis points of contribution from the LDR ... from the second quarter of 2016, or 0.3% on ...
(Date:7/26/2017)... Fla. , July 26, 2017 Sancilio ... enrollment of our clinical trial evaluating Altemia TM , ... Anemia (SCA) and Sickle Cell Disease (SCD). The SCOT ... evaluate the efficacy and safety of Altemia TM ... is conducted under US IND 125274. ...
(Date:7/24/2017)... N.Y. , July 24, 2017 IBM (NYSE: ... the Gartner Magic Quadrant for Solid-State Arrays (SSA) for the ... According to Gartner, "Vendors in the Leaders ... and Completeness of Vision. A vendor in the Leaders quadrant ... needed to drive the acceptance of new technologies. These vendors ...
Breaking Medicine Technology: