Navigation Links
The nanomechanical signature of breast cancer
Date:2/1/2013

Philadelphia, Pa. The texture of breast cancer tissue differs from that of healthy tissue. Using a cutting-edge tissue diagnostic device, a group of researchers in Basel, Switzerland, has determined one key difference: cancerous tissue is a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This new finding may one day help improve breast cancer diagnosis and therapy by providing a unique nanomechanical signature of tumor tissue properties that indicates the potential for the cancer to spread. The team will present its work at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

"It is slowly being recognized that a key to the cancer problem lies in the physical properties of the tumor tissue and that biomechanics plays a key role in cancer cell migration, invasion, and metastasis," explains Marija Plodinec of the University of Basel in Switzerland. However, contradictory opinions persist about tissue texture, and the information is hard to get at cellular mechanics happen at the nanoscale, 1-100 millionths of a meter. This research may help resolve the controversy.

To determine stiffness, the team applied a nanoscale microscope tip to a breast tissue biopsy to make an indentation, then visualized and measured the indentation with an indentation-type atomic force microscope, which provides unprecedented spatial resolution. "The most significant outcome of our measurements is determining that in healthy tissue the stiffness of the sample is homogeneous," Plodinec says. "Benign tissue exhibits a larger variability and malignant tissue shows a unique, very heterogeneous profile with soft and stiff parts alternating."

A key aspect of their experiment is the adaptation of atomic force microscopy to rapidly collect and correlate nanoscale stiffness measurements across entire biopsy samples. They used a device called ARTIDIS ("Automated and Reliable Tissue Diagnostics"), invented by Plodinec and colleagues Marko Loparic and Roderick Lim. Partnering with industry, their next step is to develop ARTIDIS into an easy-to-use device for clinical application, hopefully within two years.

"A critical advantage of ARTIDIS technology, as we see it, is that it provides an estimate of tumor aggressiveness and metastatic spread based on the unique nanomechanical signature," Plodinec says. "This signature may have potential prognostic and predictive value as a marker for therapeutic applications."


'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers validate molecular signature to predict radiation therapy benefit
2. URMC researchers connect new genetic signature to leukemia
3. Moffitt researchers identify unique immune gene signature across thousands of patients solid tumors
4. ABC Home & Commercial Services’ Houston Branch Now Offering Discount on Initial Service with Signature Rodent Agreement
5. Personal epigenetic signatures found consistent in prostate cancer patients metastases
6. The Tampa Signature Massage Center Announces Couples Massage Awareness Month
7. Eliminating the good cholesterol receptor may fight breast cancer
8. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
9. Researchers develop a new cell and animal model of inflammatory breast cancer
10. Scientists uncover multiple faces of deadly breast cancer
11. Depo-Provera Birth Control Might Raise Breast Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... ... seen a significant spike in their clients' employee participation for their wellness initiatives. ... screening by implementing a high-deductible health plan with outcome-based deductible incentives. As a ...
(Date:5/25/2016)... ... May 25, 2016 , ... Consumer access to organic foods and grower ... a maker of whole grain cereals and other plant-based foods, will introduce the first ... red winter wheat processed by Hesco/Dakota Organic Products. , The transitional designation means the ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... that it will join America's leading engineers at the American Society of Safety ... Georgia World Congress Center. , Engineers, speakers and exhibitors from more than ...
(Date:5/25/2016)... ... 25, 2016 , ... American Spine in Frederick, Maryland is ... surgeries in the Montgomery County, Howard County and Washington, D.C. areas, renowned spine ... American Spine every Monday. He will also perform surgeries in our Germantown surgical ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... Sterling Global ... feature a unique and patented refillable hanging wipe dispenser. The campaign kick-off video is ... and will end June 25, 2016. The goal is to raise $1,000 per day ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 ... "Patient Handling Equipment Market by Product (Wheelchair, Scooters, ... Care (Bariatric Care, Critical Care, Wound), Accessories (Lifting, ... Forecast to 2021", published by MarketsandMarkets, the patient ... 17.18 Billion by 2021 at a CAGR of ...
(Date:5/23/2016)... Transparency Market Research has published ... Market - Global Industry Analysis, Size, Share, Growth, Trends, ... report, the exocrine pancreatic insufficiency market is anticipated to ... 2023 to reach US$2.85 Bn by 2023. ... the deficiency of the exocrine pancreatic enzymes, causing failure ...
(Date:5/23/2016)... , May 23, 2016 The World Health ... PrePex device to include adolescents aged 13 years, and ... can be offered for adult and adolescent males in the ... . PrePex was the first male circumcision device to ... MedTech,s CEO, Eddy Horowitz said: " The ...
Breaking Medicine Technology: