The missing link between belly fat and hear...(n the abnormal reaction of the bodys im...),Health
n the abnormal reaction of the bodys immune system to its own tissue and in the damage that immune-system cells and molecules can inflict.
Since normal mice dont develop atherosclerosis, the team had to turn to a strain that had been developed to be especially prone to high cholesterol and hardened arteries. These ApoE-negative mice, as they are called, were divided into three groups: two that received fat transplants from normal mice, and one that did not, but that had the same operation that would be used to implant the fat in other mice.
Some of the fat-transplant ApoE-negative mice received transplants of visceral fat, which forms in the belly around the major organs, while others received transplants of subcutaneous fat the type thats found just under the skin throughout the body.
Sure enough, the mice that received the visceral fat transplants developed atherosclerosis at a much-accelerated rate, and experienced the same type of inflammation as the leptin-deficient mice had. Meanwhile, those that received subcutaneous fat did not experience an increase in atherosclerosis despite having increased inflammation. The mice that had the sham operations developed neither inflammation nor increased atherosclerosis.
There appeared to be an interaction between the macrophages causing the inflammation in the visceral fat, and the process of atherosclerosis, says Eitzman, who notes that blood vessels far from the site of the fat transplant developed increased atherosclerosis.
Finally, the team attempted to calm the inflammation and curb the atherosclerosis by treating the mice with pioglitazone a member of the class of drugs called thiazolidinediones or TZDs that are often used to treat diabetes. While TZD drugs have an impact on metabolism, which makes them useful in diabetes, they also have been discovered to have an anti-inflammatory effect.
And in fact, the drug reduced both the concentration of macrophag
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| Contact: Kara Gavin kegavin@umich.edu 734-764-2220 University of Michigan Health System Source:Eurekalert |
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