Navigation Links
The metabolic effects of antipsychotic drugs
Date:7/11/2011

07/07/11, Clearwater Beach, FL. Research to be presented at the upcoming annual meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, may explain why some antipsychotic drugs can promote overeating, weight gain, and insulin resistance.

Olanzapine, an atypical antipsychotic drug approved by the FDA for the treatment of schizophrenia and bipolar disorder, has been associated with body weight gain and impaired glucose homeostasis in humans and in experimental animals. As part of a Dutch research consortium, studies led by Simon Evers (University of Groningen, the Netherlands) sought to reveal underlying mechanisms for olanzapine's metabolic effects by studying healthy adult male volunteers. The research was motivated by observations of what co-author Anton Scheurink described as "a mysterious interaction between schizophrenia and diabetes."

Their results confirmed previous findings that olanzapine induces weight gain by increasing caloric intake, but also revealed that olanzapine reduces body temperature, which contributes to decreased energy expenditure. Indeed, reduced body temperature after olanzapine treatment may generate many of the known side effects of this antipsychotic drug. The authors' new findings also demonstrate that olanzapine alters peripheral glucose metabolism, which may contribute to impaired insulin sensitivity. According to lead author Simon Evers, "Our research group believes that reduced body temperature is the foremost direct and consistent effect of olanzapine in humans and in experimental animals. Reduced body temperature might explain several of olanzapine's metabolic side effects, including increased food intake, reduced energy expenditure, sedation, high blood sugar, body weight gain, and insulin resistance."


'/>"/>

Contact: Jamie Price
jamie@spltrak.com
312-238-9068
Society for the Study of Ingestive Behavior
Source:Eurekalert

Page: 1

Related medicine news :

1. Metabolic shift may offer early cancer clue
2. Increased metabolic rate may lead to accelerated aging
3. Researchers identify the metabolic signaling pathway responsible for dyslipidemia
4. Metabolic syndrome may increase risk for liver cancer
5. Mediterranean Diet Reduces Risk of Metabolic Syndrome
6. Metabolic syndrome found in 52 percent of patients after liver transplantation
7. Vitamins C and E linked to metabolic syndrome in low-income Ecuadorians
8. Loud snoring and insomnia symptoms predict the development of the metabolic syndrome
9. Moderate alcohol consumption lowers the risk of metabolic diseases
10. Metabolic status before pregnancy predicts subsequent gestational diabetes
11. UC San Diego researchers find cause of metabolic disease -- and possible cure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 18, 2017 , ... Western University of Health Sciences ... to launch the University’s new Center for Innovation on Wednesday, September 6, 2017. , ... Lecture Hall 1, followed by a technology exhibition from 1 to 3 p.m. showcasing ...
(Date:8/19/2017)... ... August 19, 2017 , ... Praeclarus Press has ... These illustrations show the diversity of the breastfeeding mothers, using bright colors ... of sizes. These illustrations are also available on tote bags, notepads, smartphone cases, ...
(Date:8/18/2017)... Thailand (PRWEB) , ... August 19, 2017 , ... ... Business, Tourism Authority of Thailand presided over the Amazing Thailand Health and Wellness ... in Thailand. , Mr. Noppadon Pakprot, Deputy Governor for Tourism Products and Business ...
(Date:8/18/2017)... ... August 18, 2017 , ... August 18, ... & Hearing,” advocating for active, healthy lifestyles and highlighting the importance of proactive ... with hearing impairments and shares the latest innovations in hearing aid technology. ...
(Date:8/18/2017)... WV (PRWEB) , ... August 18, 2017 , ... ... financial consulting services and asset protection assistance to communities in North-Central West Virginia, ... provide critical services to at-risk boys in the area. , The Chestnut Mountain ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... 3, 2017  Agragen, LLC, a ... the biopharmaceutical, nutraceutical, and aquacultural feed sectors, announces ... lead drug candidates, AGR131.  This drug is designed ... the blood of patients suffering from inflammatory conditions ... disease. Biological ...
(Date:8/2/2017)... 2017 Fenita J. Caldwell ... Pinnacle Lifetime Professional in the Field of Healthcare. ... Turing Pharmaceuticals, AG. Her skills and areas of ... ... of experience as a highly successful sales specialist ...
(Date:8/2/2017)... AURORA, Ore. , Aug. 2, 2017  Life Flight ... Call Agreement. The agreement improves patient care and operational efficiency ... Springfield , Cottage Grove ... ICU level medical transportation. PeaceHealth and Life Flight Network work ... care available during transport, or when a time sensitive emergency ...
Breaking Medicine Technology: