Navigation Links
The making and unmaking of stem-like, aggressive breast cancer cells
Date:8/9/2012

Breast cancers that depend on the hormones estrogen and progesterone are susceptible to treatments targeting these hormones. Take away this dependence and you lose a valuable treatment option. A University of Colorado Cancer Center study published as a featured article in the journal Oncogene shows how progesterone does just this by suppressing a key microRNA, progestins return breast cancer cells to a stem-cell-like state in which they haven't yet differentiated, and are thus more resistant to chemotherapies and more likely to carry a poor prognosis.

"The reason we were looking into the possible role of microRNAs in the dedifferentiation of breast cancer cells into this aggressive, chemo-resistant phenotype is that microRNAs tend to be good, druggable targets. Because one microRNA may regulate many genes involved in a cancerous signaling pathway, we hoped to find one target with many beneficial effects," says Diana Cittelly, PhD, postdoctoral fellow at the CU Cancer Center and the paper's first author. The study was a collaboration between the CU Cancer Center labs of Jennifer Richer, PhD, and Carol Sartorius, PhD.

Specifically, the study shows that progestins regulate miRNA-29 a molecule that helps to decide which of a cell's genes are and are not turned into proteins. This regulation of miRNA-29 creates a cascade that stimulates breast cancer cells to revert back to a stem-like state, marked by proteins CD44 and CK5. In animal models, these stem-like cells helped breast cancer evolve around the blockages of current treatments..

"We can manipulate this miRNA-29 in cell lines," Cittelly says, "and we hope technology isn't too far in the future that will allow us to deliver miRNA-29 in human cancers as well."

Turn off the role of miRNA-29 and the hope is that breast cancers won't be able to gain stem cell-like traits and lose their hormone dependence.


'/>"/>
Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1

Related medicine news :

1. Making it easier to learn to read
2. Neuroeconomics to study decision-making in anxious individuals
3. First Is Viewed as Best When Making Quick Decisions
4. New Electronic Cigarette Free Trial Kit Adds More Years to Smokers Life by Making it Easy to Quit Smoking
5. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
6. Making bad worse for expectant mothers
7. After 25 years, World No Tobacco Day is making an impact
8. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
9. Brain Changes May Hamper Decision-Making in Old Age
10. Research identifies a promising new therapeutic target for aggressive breast cancer
11. Researchers study vaccine as potential weapon against aggressive brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... 2015 Indiana Fiber Network, LLC (IFN), ... Computer Services, Inc (BCS) has selected IFN as a ... “The technology, service, and working relationship with IFN has ... local feel you get with IFN. I like ... makes local decisions and operates as a local community ...
(Date:5/3/2015)... (PRWEB) May 03, 2015 SpineFrontier, a ... from the FDA to produce and market their new ... can be used in outpatient settings and is compatible ... alternate posterior approach has been extensively researched and refined ... approval to use this approach in conjunction with a ...
(Date:5/2/2015)... May 02, 2015 Ticket Down has secured ... for the long awaited event today, Saturday, May 2nd at ... boxing fans will be able to secure tickets for both ... fight that boxing fans have wanted for more than five ... Floyd “Money” Mayweather will step inside the ring to fight ...
(Date:5/2/2015)... New York, NY (PRWEB) May 02, 2015 ... – when a deadly natural disaster strikes anywhere on ... ways to leverage human sympathy and compassion for their ... US-CERT (United States Computer Emergency Readiness Team) issued ... warning users “of potential email scams citing the earthquake ...
(Date:5/2/2015)... 02, 2015 Kare Visits LLC. launched in ... busy caregivers. Kare Visits offers relief for caregivers by ... facilities. According to the Caregiver Action Network, eight ... of 20 hours a week caring for an elderly or ... to hire a nurse, a caregiver is now empowered to ...
Breaking Medicine News(10 mins):Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 3Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2
... 3 Health Care Service Corporation (HCSC),which operates the ... Oklahoma and Texas, today announced that its board of ... chief executive officer,effective Nov. 1, 2008., Hemingway Hall, ... since November 2007, will succeed Raymond F. McCaskey, who ...
... emergency physicians access to earn CME ... credit for watching online video procedures, NEW ... leading global provider of information resources for the,scientific and ... the largest membership organization for emergency,physicians, to launch Continuing ...
... Educational resources and special product offers available in store during ... American Diabetes Month ... retail pharmacy, is educating patients about managing and,preventing diabetes during ... during the month on products for patients,with diabetes., Nearly ...
... is available in German . , SARS, ... becoming increasingly frequent. And we still don,t have vaccines for ... classes of viral diseases is the zoonosis, which can be ... of these is caused by the West Nile virus (WNV), ...
... have found that reducing the levels of vascular endothelial growth ... new blood vessel growth, in adult mice causes the death ... that are essential to visual function. This finding, published in ... for the chronic use of promising new anti-VEGF drugs such ...
... Program; Inaugural Partner for ... Fund(R), LONDON, Nov. 3 Susan G. ... organization in the world, is teaming with,Samsung Electronics ... in Europe, in a collaboration unparalleled in the ...
Cached Medicine News:Health News:Hemingway Hall Named CEO of Health Care Service Corporation 2Health News:McGraw-Hill Professional and American College of Emergency Physicians Roll Out CME Functionality On AccessEmergency Medicine 2Health News:McGraw-Hill Professional and American College of Emergency Physicians Roll Out CME Functionality On AccessEmergency Medicine 3Health News:CVS/pharmacy Helps Patients Manage Diabetes Care 2Health News:Therapeutic vaccines 2Health News:Anti-VEGF drugs for retinal diseases could have serious side effects, scientists caution 2Health News:Anti-VEGF drugs for retinal diseases could have serious side effects, scientists caution 3Health News:Samsung and Susan G. Komen for the Cure(R) Launch Historic Breast Cancer Alliance 2Health News:Samsung and Susan G. Komen for the Cure(R) Launch Historic Breast Cancer Alliance 3
(Date:5/1/2015)... and Markets ( http://www.researchandmarkets.com/research/pjbxjd/us_aco_it ) has announced ... Outlook 2018" report to their offering. ... ACO would grow at a CAGR of 22% during ... has been studied on three main grounds viz. spending ... Our research provides current market estimation and forecast till ...
(Date:5/1/2015)... , May 1, 2015 At the American ... in Washington D.C. , Elekta will ... that enables clinicians to leverage the enormous amount of ... treatments conducted each year – to advance clinical research ... Registry is a cloud-based solution that allows practitioners to ...
(Date:5/1/2015)... , May 1, 2015 The Institute for ... health literacy award winners. The IHA Health Literacy Awards ... an impact on the practice of educating or empowering ... IHA gives awards in three categories: innovative programs, published ... Health Literacy Hero award. In the area ...
Breaking Medicine Technology:United States ACO IT Spending Outlook 2014-2018 2Elekta to showcase Leksell Gamma Knife Registry at AANS Annual Meeting 2Elekta to showcase Leksell Gamma Knife Registry at AANS Annual Meeting 3Institute for Healthcare Advancement Announces 2015 Award Winners 2
... Awarepoint Corporation , the leading provider of ... today that it named Ralph Keiser as executive vice ... president of marketing and business development to accommodate explosive ... domestic and international RTLS markets. (Logo: ...
... NEPH) announced today financial results for the three months ended March ... Increased revenues of $164,000 or 32% in the first quarter ... Rights Offering and Private Placement resulting in gross proceeds of approximately ... represented a transition period for Nephros," said Dr. Paul Mieyal, acting ...
Cached Medicine Technology:Awarepoint Expands Senior Management Team 2Awarepoint Expands Senior Management Team 3Nephros Reports First Quarter 2011 Financial Results 2Nephros Reports First Quarter 2011 Financial Results 3Nephros Reports First Quarter 2011 Financial Results 4Nephros Reports First Quarter 2011 Financial Results 5
... instrument engineered to match the speed of ... system is based on heat transfer by ... tubes or thin walled micorcentrifuge tubes. Heating ... high velocity air results in nearly instantaneous ...
Contains: Card, cabling and instructions to remotely access a RoboCycler® instrument from a PC or Macintosh® computer...
... Biosystems has designed its 60-well, 0.5 mL ... PCR applications (both DNA and RNA). The ... Frame ensure oil-free operation in the 0.5 ... the 0.5 mL GeneAmp PCR System 9700 ...
... Mx3005P instrument and custom filter wheels ... filters. The standard filter set includes: ... ROX/Texas Red (585nm-610nm), Cy5 (635nm-665nm) and ... Mx3005P analysis software, Beacon Designer oligo ...
Medicine Products: