Navigation Links
The language of RNA decoded: Study reveals new function for pseudogenes and noncoding RNAs
Date:6/23/2010

imension by which cellular and tumor biology can be regulated, and effectively doubling the size of the functional genome."

MicroRNAs are small RNA molecules that repress the expression levels of numerous genes by binding to mRNA, thereby preventing it from delivering its protein coding message. As a result, microRNAs are known to have a hand in human diseases, including cancer.

But, the Pandolfi team thought that RNA might be taking a different tactic. "Although it is conventional knowledge that microRNA can block mRNA function, we suspected that the roles of microRNA and mRNA were actually flipped," explains Pandolfi. "In other words, instead of microRNA binding to mRNA, we thought that RNAs were actually sequestering the microRNAs, thereby protecting mRNA and rendering the microRNAs ineffective on their other targets."

And, indeed this proved to be the case. The authors coined the term "competitive endogenous RNAs" or "ceRNAs" to describe this new RNA activity.

To further test their hypothesis, the scientists turned to pseudogenes, a group of "genetic relics" that do not encode for proteins. Since pseudogenes are more or less identical to their ancestral genes, the authors knew they would be the perfect "combatants" because they would both recognize and compete for the same group of microRNAs as their ancestral genes.

The scientists studied the interaction between the RNA encoding for the PTEN tumor suppressor gene and its closely related pseudogene, PTENP1. Through this new mechanism, they were able to demonstrate that PTENP1 also acts as a tumor suppressor. They also proved this to be true for the KRAS oncogene and its pseudogene KRAS1P; in this case the pseudogene was acting as a new oncogene.

"We now understand how these RNA units talk with one another," says Pandolfi. "Because all RNA molecules are competing to be heard, it had been difficult to tease out the messages amid the noise. But now that we know
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mixed-handed children more likely to have mental health, language and scholastic problems
2. Health Reform Bill Needs More Work Despite New Language on Abortion, Say Catholic Bishops
3. New 20 Year Research Confirms the Biblical Assertion that Hebrew is the Original Proto-Language Confounded By the Gods
4. Language Service Leader Expands to Meet Booming, Global Industry Demand.
5. Second Language Comes Faster When Taught in Own Accent
6. A mothers sensitivity may help language growth in children with autism spectrum disorder
7. Yakult USA Launches Spanish-Language Website
8. In brain-injured children, early gesturing predicts language delays
9. Language dysfunction in children may be due to epileptic brain activity
10. Kids with hearing loss in 1 ear fall behind in language skills
11. Differences in language circuits in the brain linked to dyslexia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... 18, 2015 PHOENIX, ARIZONA – In ... with 11 other secure destruction professionals across the United ... (CSDS). He will now display “CSDS” as a professional ... before the National Association of Information Destruction 2015 Annual ... Grapevine, Texas. Of the 20 people who took the ...
(Date:4/17/2015)... (PRWEB) April 18, 2015 Rosetta Radiology ... facility, rounding out their list of diagnostic imaging services. ... for patients on the Upper East Side of Manhattan. ... at full capacity. The addition of PET-CT, combined with ... physicians the ability to work with patients through several ...
(Date:4/17/2015)... April 17, 2015 Florida Hospital Wesley ... and Florida Hospital Carrollwood were all selected as Top ... located in Pasco County, is ranked number one for ... survey, which was conducted in partnership with an independent ... all-private bed hospital that opened in October of 2012 ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Consumers who ... protection without modifications can now use the Insurance Pros ... life insurance policy rates that are featured by leading ... standard plans that are offered are mixed between three ... 18 to 79. There are now term, universal and ...
(Date:4/17/2015)... 2015 At the end of February ... the “Salute to the Oscars” in the Stardust Penthouse ... overlooking the impressive Los Angeles skyline. These events honoring ... Durkin, LA’s leading producer of sustainable product placement in ... world’s premier providers of eco-friendly and socially conscious products ...
Breaking Medicine News(10 mins):Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 3Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 4Health News:General Life Insurance Policy Rates Added to Quotation System at Insurance Website Online 2Health News:Choices Recovery Speaks with Dakota Hood of “The Hunger Games” about Addiction in Hollywood 2
... It appears that stroke patients who receive both intravenous ... blood clots and endovascular interventions such as ... likely to recover and have lower chances of dying, ... Research Center at the University of Minnesota Medical School., ...
... documentary from Peabody-Award-winning filmmaker,Joseph Lovett - premieres December ... Trailer available at http://www.blooddetectives.org ., ... conjunction with the American Society of,Hematology (ASH) presents ... on December 19, 2008, at 7:00 PM ET/PT ...
... Puerto Rico and District of Columbia get failing grades , , ... premature birth rates, the United States rates a "D," and ... get failing grades. , That,s the sobering conclusion of the ... , released Wednesday. Not a single state earned an "A." ...
... TORRANCE, Calif., Nov. 12 A study published ... energy drinks can cause,caffeine intoxication. It suggested product ... intoxication include nausea, headache, heart,palpitations, insomnia, anxiety or ... comes from the high levels of caffeine,and sugar ...
... Cycling ... iPhone Apps, ... leader in indoor group cycling, today introduced,the new iSPINNING(TM) fitness application ... time only, is an innovative new,cardio and cycling application that compiles ...
... software MCT-Diabetes, has announced that nationally-recognized diabetes specialist Dr. Steven ... regularly scheduled online column to the MyCareTeam diabetes community. ... ... 2008 -- MyCareTeam, Inc., a leading vendor of Internet-based diabetes ...
Cached Medicine News:Health News:Dual treatment for stroke leads to improved recovery rates, reduced mortality 2Health News:Documentary Examining Deadly Blood Disorders and Lifesaving Research to Premiere on Discovery Health 2Health News:Documentary Examining Deadly Blood Disorders and Lifesaving Research to Premiere on Discovery Health 3Health News:U.S. Gets a 'D' for Preterm Birth Rates 2Health News:Study Calls for Labeling of Potentially Dangerous Energy Drinks 2Health News:Spinning(R) Announces First Heart Rate and Fitness Application for the iPhone(TM) and iPod(R) touch 2Health News:Spinning(R) Announces First Heart Rate and Fitness Application for the iPhone(TM) and iPod(R) touch 3Health News:Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community 2Health News:Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community 3
(Date:4/17/2015)... , Apr. 17, 2015 Research and Markets ... addition of the "Medical Device Outsourcing - ... offering. This report analyzes the worldwide ... by the following Device Categories: Class I, Class ... analyzed in the report Include - Radiology, Orthopedic, ...
(Date:4/17/2015)... 17, 2015  Trovagene, Inc., (NASDAQ:  TROV) a ... clinical data presented at the 2015 European Lung ... Cancer Monitoring ℠ (PCM) platform outperformed tissue ... EGFR T790M mutations in metastatic lung cancer ... T790M Mutation in Urinary Circulating Tumor DNA from ...
(Date:4/17/2015)... Apr. 17, 2015 Steven Rash , the ... and its operating subsidiary American Seed & Oil Company, ... to investors yesterday in New York City.  Mr. Rash,s ... The American Seed & Oil Company has recently announced ... Butter Hemp Seed Foods , the EpiVape , ...
Breaking Medicine Technology:Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 2Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 4American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 2American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 3
... Pa. , May 3 Unisys Corporation announced today ... information management (HIM) business to Molina Healthcare, Inc. for $135 ... , , ... solutions and business process outsourcing services to state governments for administering ...
... LONDON , May 3, 2010 The ... 2016, but,a familiar name, Pfizer, will still be the biggest seller of ... today,by EvaluatePharma, the premier provider of pharma and biotech analysis. , ... The cancer ...
Cached Medicine Technology:Unisys Completes Sale of Health Information Management Business 2Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot 2Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot 3Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot 4Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot 5
Galaxy IVUS Imaging System simplifies the process of intracardiac echo while delivering accurate, real-time diagnostic information in less time with less work. (Ultra ICE catheter compatible)...
The Duett Pro is simple, precise and efficient. Duett Pro sleeve hub is lightweight and ergonomic. A 'quick connect' feature provides a secure connection of the sleeve hub to the base during catheter...
... VasoSeal VHD was ... rapidly stop bleeding after ... and radiology procedures. It ... sealing device approved for ...
... was the first device ... after diagnostic and interventional ... It is a collagen-based ... for immediate sheath removal ...
Medicine Products: