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The importance of standardizing drug screening studies
Date:12/2/2013

Montral, December 2, 2013 A bioinformatics expert at the IRCM, Benjamin Haibe-Kains, recently published an article stressing the importance of standardizing drug screening studies in the prestigious scientific journal Nature. The study supports the need for further development and standardization to improve the reproducibility of drug screening studies, as they are important in identifying new therapeutic agents and their potential combinations with existing drugs.

Dr. Haibe-Kains's article investigated results from two large-scale pharmacogenomic studies the Cancer Genome Project (CGP) and the Cancer Cell Line Encyclopedia (CCLE) published last year in Nature. The main goal of these studies was to identify genomic biomarkers that could predict patients' response to anticancer drugs. Because cancer patients often exhibit varied responses to anticancer treatments, and evidence indicates that response is determined in part by patient-specific genome alterations, cancer cell line studies have long been used to test the efficacy of therapeutic agents and explore genomic factors associated with drug response. These two studies screened multiple new and approved drugs on nearly 1,000 panels of cancer cell lines, of which 15 drugs and 471 cell lines were common.

"These studies provided us with a unique opportunity to look at the reproducibility of biomarker discovery in preclinical settings," says Dr. Haibe-Kains, Director of the Bioinformatics and Computational Biology research unit at the IRCM. "Our objective was to examine the uniformities and inconsistencies between results from the two independent studies, and assess the potential of building predictive models of drug response on the basis of those results."

Dr. Haibe-Kains and his research team observed overall good consistency of genomic profiles, which contain information about all the genes in the body and can be used to determine response to a drug. However, drug
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Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

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