Navigation Links
The immune system's role in hepatitis C recurrence after liver transplantation
Date:4/1/2009

A new study pinpoints certain aspects of the immune system that may play a role in the recurrence and progression of hepatitis C virus (HCV) after liver transplantation. The study is in the April issue of Liver Transplantation, a journal published by John Wiley & Sons. The article is also available online at Wiley Interscience (www.interscience.wiley.com).

Hepatitis C virus (HCV), which can lead to cirrhosis and liver cancer, is the leading indication for liver transplantation in the U.S. Unfortunately, the infection almost always recurs, and in about 30 percent of cases, it causes cirrhosis in the transplanted liver within five years.

Researchers don't know exactly why some patients fare worse than others, but have been trying to understand the causes. They suspect it is related to the immunological response to HCV which involves natural killer (NK) cells and the killer cell immunoglobulin-like receptors (KIR) which recognize HLA Class I antigens.

Researchers, led by Francesca Poli of Italy, examined the role of KIR genotypes and their HLA ligands in both HCV disease recurrence and its progression after liver transplantation. They retrospectively studied 151 donor-recipient pairs for transplants that occurred between 1991 and 2001. They examined liver biopsies from the recipients that were taken at 1, 3, 5, 7 and 10 years post-transplant to determine when hepatitis recurred, the degree of fibrosis and the progression to cirrhosis.

They found that hepatitis was more likely to recur when the KIR-HLA-C ligands were mismatched between donor and recipient. Also, the presence of KIR2DL3 in the recipient correlated to progression to liver fibrosis.

"Our preliminary data indicates that KIR2DL3 positive recipients would be better assigned a matched donor for the HLA-KIR ligands in order to reduce the risk of developing severe fibrosis after liver transplantation," th
'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. TV crime drama compound highlights immune cells misdeeds
2. Dendritic cells ensure immune tolerance
3. New Study Shows Probiotic Strain Effective in Boosting Immune Response
4. Immune-based drug approved in Europe for pediatric cancer patients
5. Protein helps immune cells to divide and conquer
6. Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes
7. Immune reaction to metal debris leads to early failure of joint implants
8. Varicella zoster infection causes severe autoimmune hepatitis
9. Frost & Sullivan Lauds Aesku.Diagnostics For Providing an Overall Analysis Platform For a Wide Range of Autoimmune Complications
10. Genetic evidence points to potential therapeutic bypass for autoimmune process
11. German Medical Advancement Reflects Major Improvement in Individuals with Common and Chronic Illnesses Related to Immune System Dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Westlake Village, CA (PRWEB) September 23, 2014 ... Sedation Dental Office is now offering complimentary oral sedation ... about 15 percent of Americans suffer from dental anxiety ... merely uncomfortable for patients; they can also keep patients ... dental anxiety or phobia in Westlake Village and surrounding ...
(Date:9/23/2014)... September 23, 2014 PM360, a leading ... the pharmaceutical industry with their annual Trailblazer Awards on ... gala banquet at Gotham Hall in New York City, ... representing top talent and brands. , ... says Anna Stashower, CEO and Publisher of PM360. “We ...
(Date:9/23/2014)... 23, 2014 Kenall Manufacturing, a ... its MedMaster™ M4 product line with a new ... M4 product line – currently available with 2'×2' ... providing more flexibility when designing lighting for the ... M4 Series include:, •Three sizes available to ...
(Date:9/23/2014)... Rockville, MD (PRWEB) September 23, 2014 ... a proposal by the World Health Organization (WHO) regarding ... , USP supports the effort by the Expert Group ... develop a consensus-based global approach to the naming of ... principles critical to the quality assessment of these drugs. ...
(Date:9/23/2014)... 2014 Catalent Pharma Solutions, ... technologies and development solutions for drugs, biologics ... it had reached an exclusive development and ... Cingulate Therapeutics (CTx), to support the development ... products for the treatment of Attention Deficit/Hyperactivity ...
Breaking Medicine News(10 mins):Health News:The Sedation Dental Office is Now Offering Complimentary Oral Sedation with Treatment for New Patients 2Health News:The Sedation Dental Office is Now Offering Complimentary Oral Sedation with Treatment for New Patients 3Health News:PM360 Magazine Announces Winners of 2014 Trailblazer Awards 2Health News:PM360 Magazine Announces Winners of 2014 Trailblazer Awards 3Health News:PM360 Magazine Announces Winners of 2014 Trailblazer Awards 4Health News:PM360 Magazine Announces Winners of 2014 Trailblazer Awards 5Health News:PM360 Magazine Announces Winners of 2014 Trailblazer Awards 6Health News:Kenall Expands MedMaster™ M4 Surgical Suite Product Portfolio with New 1'×4' Option 2Health News:Kenall Expands MedMaster™ M4 Surgical Suite Product Portfolio with New 1'×4' Option 3Health News:USP Comments to WHO Regarding Biologics Qualifier Proposal 2Health News:Catalent and Cingulate Therapeutics Sign Exclusive Agreement for Development of New ADHD Treatments 2Health News:Catalent and Cingulate Therapeutics Sign Exclusive Agreement for Development of New ADHD Treatments 3
... HOUSTON - A $4 million, five-year grant from the ... Networks Program Center (CNPC), called Latinos Contra El Cancer, ... The center is a joint project of The ... School of Public Health and The University of Texas ...
... low-dose radiation from cardiac imaging and other procedures after ... of cancer, found a new study published in ... link only) http://www.cmaj.ca/embargo/cmaj100463.pdf . The use of ... (CT) angiography and nuclear scans, is increasing which has ...
... of Sweden decided to introduce a special blessing for ... making a distinction between genuine homosexuality and promiscuous homosexuality, ... a new thesis in religious studies at the University ... between opponents and supporters of the decision. "It ...
... rates continue to rise, University of Missouri researchers are ... an effective and inexpensive way for people with addictive ... Matthew Martens, associate professor of Educational, School and Counseling ... team of researchers received a $172,500 grant from ...
... produced by the DNA of tumor cells, researchers have ... new treatment for the often-fatal childhood cancer neuroblastoma. Oncologists ... of a drug that blocks the protein,s activity. ... target for high-risk neuroblastoma," said pediatric oncologist Kristina A. ...
... two new works, an anthropologist tackles a perplexing question relating ... tolerate and even celebrate the public display of ... of Real Human Bodies " is the most widely attended ... professor of anthropology at the University of Illinois and author ...
Cached Medicine News:Health News:Project connects researchers, Latino communities to prevent cancer 2Health News:Project connects researchers, Latino communities to prevent cancer 3Health News:Risk of cancer increases with exposure to low-dose radiation 2Health News:Supporters and opponents of a special blessing for homosexuals share many values 2Health News:Simple feedback could be effective therapy for addictive behaviors 2Health News:Protein may be key to new treatment in a childhood cancer 2Health News:Protein may be key to new treatment in a childhood cancer 3Health News:Anthropologist: 'Body Worlds' visitors confront bodies but not death 2Health News:Anthropologist: 'Body Worlds' visitors confront bodies but not death 3
(Date:9/23/2014)... , Sept. 23, 2014 Today, DripDrop, the ... the formation of the DripDrop Foundation, with its ... dehydration worldwide. Utilizing scientific advancements in Oral Rehydration ... to reduce dehydration and healthcare costs through strategic ... "DripDrop has been used in ...
(Date:9/23/2014)... , Sept. 23, 2014   BioLife Solutions ... developer, manufacturer and marketer of proprietary clinical grade ... and precision thermal shipping products for cells ... new additions to its Scientific Advisory Board.  The new ... Anthony Davies , PhD. Dr. Acker is ...
(Date:9/22/2014)... BARCELONA , España, September 23, 2014 ... nube permite que los patrocinadores de ensayos clínicos satisfagan ... a la accesibilidad y exhaustividad de los expedientes permanentes ... La mayor encuesta sobre TMF en el ... un aumento en el número de patrocinadores de ensayos ...
Breaking Medicine Technology:DripDrop Forms Foundation To Scale Relief Efforts 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 3BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 4BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 5BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 6BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 7El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 2El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 3El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 4El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 5
... Adeona Pharmaceuticals, Inc. (AMEX: ... for serious central nervous system diseases, announced today ... the randomized, double-blind, placebo-controlled, multi-center clinical trial of ... multiple sclerosis (MS) in women, per the original ...
... MARLBOROUGH, Mass., Sept. 19, 2011 Advanced Cell Technology, ... of regenerative medicine, announced today that it has been ... the Company,s proprietary method for generating and expanding hemangioblast ... an exclusive license to commercialize the patented technology in ...
Cached Medicine Technology:Adeona Announces Completion of Planned Enrollment in Phase II Multiple Sclerosis Clinical Trial 2Adeona Announces Completion of Planned Enrollment in Phase II Multiple Sclerosis Clinical Trial 3Adeona Announces Completion of Planned Enrollment in Phase II Multiple Sclerosis Clinical Trial 4Adeona Announces Completion of Planned Enrollment in Phase II Multiple Sclerosis Clinical Trial 5ACT Secures First Patent for Generating Hemangioblast Cells to Treat a Broad Spectrum of Vascular and Hematopoietic Disorders 2ACT Secures First Patent for Generating Hemangioblast Cells to Treat a Broad Spectrum of Vascular and Hematopoietic Disorders 3ACT Secures First Patent for Generating Hemangioblast Cells to Treat a Broad Spectrum of Vascular and Hematopoietic Disorders 4
QualCraft™ Radiation Protection Eyewear providex maximum comfort and eye protection! Lenses made of 0.75 mm leaded glass. Side shields of 0.30 mm leaded acrylic help seal out scatter radiation ...
Clip-On Glasses clip onto regular eyewear frames. Plano (nonprescription) only. Will not fit over high-plus or high-minus presciptions, or over glasses with thick frames. Black wire frames. Wt. 63 g....
Qualcraft™ Radiation Readers, Wraparound Glasses. Protect yourself and have close-vision clarity....
The Bronze Metalite Constructed of optical-grade steel with bronze electroplate. Fitted lead side shields that create a seal to the front of the lenses for increased scatter protection....
Medicine Products: