Navigation Links
The immune system's role in hepatitis C recurrence after liver transplantation
Date:4/1/2009

A new study pinpoints certain aspects of the immune system that may play a role in the recurrence and progression of hepatitis C virus (HCV) after liver transplantation. The study is in the April issue of Liver Transplantation, a journal published by John Wiley & Sons. The article is also available online at Wiley Interscience (www.interscience.wiley.com).

Hepatitis C virus (HCV), which can lead to cirrhosis and liver cancer, is the leading indication for liver transplantation in the U.S. Unfortunately, the infection almost always recurs, and in about 30 percent of cases, it causes cirrhosis in the transplanted liver within five years.

Researchers don't know exactly why some patients fare worse than others, but have been trying to understand the causes. They suspect it is related to the immunological response to HCV which involves natural killer (NK) cells and the killer cell immunoglobulin-like receptors (KIR) which recognize HLA Class I antigens.

Researchers, led by Francesca Poli of Italy, examined the role of KIR genotypes and their HLA ligands in both HCV disease recurrence and its progression after liver transplantation. They retrospectively studied 151 donor-recipient pairs for transplants that occurred between 1991 and 2001. They examined liver biopsies from the recipients that were taken at 1, 3, 5, 7 and 10 years post-transplant to determine when hepatitis recurred, the degree of fibrosis and the progression to cirrhosis.

They found that hepatitis was more likely to recur when the KIR-HLA-C ligands were mismatched between donor and recipient. Also, the presence of KIR2DL3 in the recipient correlated to progression to liver fibrosis.

"Our preliminary data indicates that KIR2DL3 positive recipients would be better assigned a matched donor for the HLA-KIR ligands in order to reduce the risk of developing severe fibrosis after liver transplantation," the authors report.

"In summary," they conclude, "the results presented in this study have shown that disparity for HLA-C allotypes between recipient and donor may increase the risk of recurrence of hepatic inflammation and evidence the importance of the KIR2DL3 receptor in the development of the disease."

They suggest these factors might be considered when selecting an HCV positive liver transplant candidate, to optimize the use of the limited number of organs available.

An accompanying editorial by Lucy Golden-Mason of the University of Colorado says that the study reveals interesting associations and the results could have important implications.

"Identifying variables before liver transplantation that predict more aggressive HCV recurrence is of importance, in particular in the context of donor organ shortage," she concurs.

"Overall," she concludes, "the data supports the model that a genetic component contributes to natural killer cell mediated control of virus as well natural killer cell mediated hepatic injury in the setting of liver transplantation for HCV."


'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. TV crime drama compound highlights immune cells misdeeds
2. Dendritic cells ensure immune tolerance
3. New Study Shows Probiotic Strain Effective in Boosting Immune Response
4. Immune-based drug approved in Europe for pediatric cancer patients
5. Protein helps immune cells to divide and conquer
6. Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes
7. Immune reaction to metal debris leads to early failure of joint implants
8. Varicella zoster infection causes severe autoimmune hepatitis
9. Frost & Sullivan Lauds Aesku.Diagnostics For Providing an Overall Analysis Platform For a Wide Range of Autoimmune Complications
10. Genetic evidence points to potential therapeutic bypass for autoimmune process
11. German Medical Advancement Reflects Major Improvement in Individuals with Common and Chronic Illnesses Related to Immune System Dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... 2017 , ... Bio-Optronics Inc. is proud to announce the ... to seamlessly integrate and streamline the way researchers prepare and conduct patient visits. ... and improving efficiency significantly for users – a first in the CTMS industry. ...
(Date:1/19/2017)... ... 2017 , ... Ultimate Medical Academy (UMA) is preparing to ... making a difference in the lives of the next generation of healthcare professionals. ... educational institution, has more than 30,000 alumni and employs more than 2,000 professionals. ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... agency which serves Lawrenceville, New Jersey and the surrounding area, is inaugurating ... lateral sclerosis (ALS), more commonly known as Lou Gehrig's disease or motor neurone ...
(Date:1/19/2017)... ... ... The CHP suggests that California drivers can avoid hydroplaning as well as ... the space between themselves and other vehicles, according to a January 3 article ... notes that, rain or shine, drivers should always incorporate safe driving practices in their ...
(Date:1/19/2017)... ... January 19, 2017 , ... "ProParagraph Basics is a set ... process for all media productions," said Christina Austin - CEO of Pixel Film ... self-animating paragraphs designed for multi-lined text purposes. Choose from presets with basic, ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 18, 2017 ... Summary GlobalData,s new report, "South Korea Insulin Delivery ... the South Korea Insulin Delivery market. The report provides ... and average prices (USD) within market segments - Insulin ... Accessories. The report also provides company shares and ...
(Date:1/18/2017)... Philadelphia Pediatric Medical Device Consortium (PPDC) has announced seed grants ... Consortium chose those companies from eight finalists in a ... The devices under development are a powered orthotic arm brace ... system for emergency situations and a device that gradually corrects ... ...
(Date:1/18/2017)... PUNE, India , January 18, 2017 ... by Product Type and by Application: Global Opportunity Analysis and Industry Forecast, 2014 ... and is expected to reach $1,127 million by 2022, growing at a CAGR ... with two-fifths share, in terms of revenue. Continue ... ...
Breaking Medicine Technology: