Navigation Links
The immune system's role in hepatitis C recurrence after liver transplantation
Date:4/1/2009

A new study pinpoints certain aspects of the immune system that may play a role in the recurrence and progression of hepatitis C virus (HCV) after liver transplantation. The study is in the April issue of Liver Transplantation, a journal published by John Wiley & Sons. The article is also available online at Wiley Interscience (www.interscience.wiley.com).

Hepatitis C virus (HCV), which can lead to cirrhosis and liver cancer, is the leading indication for liver transplantation in the U.S. Unfortunately, the infection almost always recurs, and in about 30 percent of cases, it causes cirrhosis in the transplanted liver within five years.

Researchers don't know exactly why some patients fare worse than others, but have been trying to understand the causes. They suspect it is related to the immunological response to HCV which involves natural killer (NK) cells and the killer cell immunoglobulin-like receptors (KIR) which recognize HLA Class I antigens.

Researchers, led by Francesca Poli of Italy, examined the role of KIR genotypes and their HLA ligands in both HCV disease recurrence and its progression after liver transplantation. They retrospectively studied 151 donor-recipient pairs for transplants that occurred between 1991 and 2001. They examined liver biopsies from the recipients that were taken at 1, 3, 5, 7 and 10 years post-transplant to determine when hepatitis recurred, the degree of fibrosis and the progression to cirrhosis.

They found that hepatitis was more likely to recur when the KIR-HLA-C ligands were mismatched between donor and recipient. Also, the presence of KIR2DL3 in the recipient correlated to progression to liver fibrosis.

"Our preliminary data indicates that KIR2DL3 positive recipients would be better assigned a matched donor for the HLA-KIR ligands in order to reduce the risk of developing severe fibrosis after liver transplantation," th
'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. TV crime drama compound highlights immune cells misdeeds
2. Dendritic cells ensure immune tolerance
3. New Study Shows Probiotic Strain Effective in Boosting Immune Response
4. Immune-based drug approved in Europe for pediatric cancer patients
5. Protein helps immune cells to divide and conquer
6. Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes
7. Immune reaction to metal debris leads to early failure of joint implants
8. Varicella zoster infection causes severe autoimmune hepatitis
9. Frost & Sullivan Lauds Aesku.Diagnostics For Providing an Overall Analysis Platform For a Wide Range of Autoimmune Complications
10. Genetic evidence points to potential therapeutic bypass for autoimmune process
11. German Medical Advancement Reflects Major Improvement in Individuals with Common and Chronic Illnesses Related to Immune System Dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... (PRWEB) June 19, 2013 The ... program is this Friday, June 21 at midnight ... ongoing programs and innovative people who’ve raised the ... information, visit http://www.minonline.com/ima . , Any consumer ... magazine title is eligible to enter. Additionally, advertising ...
(Date:6/19/2013)... Utah (PRWEB) June 19, 2013 Today, ... Wisconsin Health Insurance Exchange . Zane Benefits, which provides ... benefits, is the leader in defined contribution ... to Zane Benefits’ website, as part of the Affordable ... small businesses will become available through new state health ...
(Date:6/19/2013)... The Journal of Parasitology – Although ... software, it creates questions of ethics. For scientific publications, ... already published case shows, scientific publications need clear guidelines ... Journal of Parasitology features a commentary on ... article published in the Journal of the New York ...
(Date:6/19/2013)... Pa. (June 19, 2013) The results of three ... of Neurosurgery , official journal of the ... published by Lippincott Williams & Wilkins , a ... study indicates that continuous "machine learning" using artificial neural ... in patients with advanced brain cancers. Another study in ...
(Date:6/19/2013)... early April, senior leaders from medical, law enforcement, military, ... one question: how can first responders improve survival after ... results of this discussion are now available in " ... ," a concept paper published in the June issue ... Acute Care Surgery , official publication of the ...
Breaking Medicine News(10 mins):Health News:Entry Deadline for min’s Integrated Marketing Awards Is This Friday, June 21 2Health News:Zane Benefits Publishes New Information on the Wisconsin Health Insurance Exchange 2Health News:Zane Benefits Publishes New Information on the Wisconsin Health Insurance Exchange 3Health News:Altered Photo in Journal Article Illustrates the Need for Manipulation Guidelines 2Health News:Neurosurgery publishes findings of 3 important studies in June issue 2Health News:Neurosurgery publishes findings of 3 important studies in June issue 3Health News:Hartford consensus aims to improve survival after mass shootings 2
... are supporting WaterAid to deliver the most wished for Christmas present in ... ... Bendalls are appealing to social media groups, the Australian blog community and ... donate and download a e-Christmas Card , with a personalized message. ...
... scientists and the news media have evolved tremendously over ... improve communications with both the media and the lay ... commentary appears this month in a major scientific journal. ... and pharmacology at Wake Forest University School of Medicine, ...
... white women to have reconstruction after mastectomy , , MONDAY, ... women are more likely to have immediate breast reconstruction ... , This is also true for more educated women ... black women and those who live in predominantly black ...
... found little link between drinking and malignancies , , MONDAY, ... your chances of developing cancer after age 65, new ... lack of physical activity were among the usual suspects ... to the Duke University study. , The findings are ...
... nanoparticles and polymer carriers as potential new techniques ... and blindness in the United States, according to ... Research Institute Conference. , The report ( http://www.iovs.org/cgi/content/full/49/11/4712 ... for ocular drug delivery to the posterior segment ...
... LAKE CITY Nov. 17, 2008 Researchers at the ... trial that uses a patient,s own stem cells to treat ... Repair Cell Treatment of Patients with Dilated Cardiomyopathy (IMPACT-DCM) study ... (CRC) and their ability to improve heart function. , Patients ...
Cached Medicine News:Health News:Urgent Request for Water 2Health News:Award-winning researcher says relationships with news media, public are critical 2Health News:Award-winning researcher says relationships with news media, public are critical 3Health News:Wealthy More Likely to Have Breast Reconstruction 2Health News:Stay Upbeat, Exercise to Help Prevent Cancer in Old Age 2Health News:Conference report highlights new research into drug delivery to treat eye disease 2Health News:U of U researchers to use patient's own stem cells to treat heart failure 2
(Date:6/19/2013)... SUNNYVALE, Calif. , June 19, 2013 ... today announced that The New England Journal of ... a Phase 1b/2 study evaluating the investigational oral Bruton,s ... chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). ... patients with relapsed/refractory CLL or SLL, even in patients ...
(Date:6/19/2013)... CHICAGO , June 19, 2013 The Physician-Patient ... reduce alarm fatigue. The need to urgently address ... in its Sentinel Event Alert #50 , "Medical device alarm ... Alert database, between January 2008 and June 2012, there were ... 80 resulted in death (82%) , 13 resulted in ...
(Date:6/19/2013)...   Voices Against Brain Cancer (VABC), a ... cancer, today announced that it has awarded Tocagen Inc. ... investigation of Toca 511 & Toca FC in patients ... (Grade 3 or Grade 4).  Tocagen is a privately ... with an initial focus on brain cancer. ...
Breaking Medicine Technology:Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 2Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 3Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 4Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 5Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 6Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals 2Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals 3Voices Against Brain Cancer Awards Grant to Tocagen to Support Investigation of Toca 511 & Toca FC in Patients with Recurrent Brain Cancer 2Voices Against Brain Cancer Awards Grant to Tocagen to Support Investigation of Toca 511 & Toca FC in Patients with Recurrent Brain Cancer 3
Post-Surgical compression garments...
... Albumin Cobalt Binding (ACB®) Test is a ... Albumin (IMA®) by measuring the cobalt binding ... sample. First identified in the early 1990s, ... in contact with ischemic tissue in the ...
... Albumin Cobalt Binding (ACB®) Test is a ... Albumin (IMA®) by measuring the cobalt binding ... sample. First identified in the early 1990s, ... in contact with ischemic tissue in the ...
... menu includes kits that quantitatively measure two ... (a). An elevated serum or plasma homocysteine ... and independent risk factor for cardiovascular disease. ... have associated elevated levels of Lp(a) with ...
Medicine Products: