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The good, the bad and the ugly: The many roles of c-JUN in cancer
Date:6/28/2011

ery that c-JUN protects not only the Cdk6 gene thereby accelerating tumour formation but also the p16 gene. p16 is a known tumour suppressor gene and its mutation or inactivation is associated with an increased risk of contracting a variety of forms of cancer. By protecting its promoter from inactivation, c-JUN seems to be helping the cells to fight the cancer.

Does this mean that the main villain of the piece is not actually as bad as we thought? Kollmann's response is fairly guarded. "I think it means that the functions of all these proteins are far more complex than we know. They all work together with many other proteins and the overall effect probably depends on a large number of factors. We have a lot more to learn before we can understand what proteins to inhibit to treat the disease."


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Contact: Veronika Sexl
veronika.sexl@vetmeduni.ac.at
43-125-077-2910
University of Veterinary Medicine -- Vienna
Source:Eurekalert

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