Navigation Links
The good, the bad and the ugly: The many roles of c-JUN in cancer
Date:6/28/2011

The process of cell division is tightly regulated, as mistakes may lead to cancer. The so-called c-JUN protein has been fingered as causing tumors in both skin and liver. The group of Veronika Sexl at the University of Veterinary Medicine, Vienna, has now uncovered a surprising detail with the discovery an additional function of c-JUN's also prevents silencing of an important anti-tumor factor. The results have recently been published in the open-access journal Oncotarget.

The c-JUN protein was initially described in the late 1980s as the mammalian equivalent of a protein responsible for causing cancer in birds. Intense research in a number of labs has subsequently led to a basic understanding of how the protein works. c-JUN is a transcription factor that modifies (phosphorylates) key regulatory proteins in the cell, thereby activating or deactivating them and leading to unregulated cell division and hence cancer. It has also become clear that c-JUN acts not on its own but in conjunction with an array of further proteins that modulate its function.

Karoline Kollmann in the group of Veronika Sexl, now at the University of Veterinary Medicine, Vienna, recently discovered an additional activity of c-JUN. Together with her collaboration partners at the Medical University of Vienna and in Madrid, she showed that c-JUN can bind to the promoter of a kinase gene, known as Cdk6, thereby preventing the gene from being inactivated (by means of methylation). The result is increased activity of Cdk6, which further stimulates cell division. c-JUN only activates transcription of Cdk6 in cancer cells, where it makes the disease progress even faster. Kollmann's work was published in April in the journal Blood (2011, Vol. 117, pp. 4065-4075).

The surprising aspect of the discovery is that the "new" function of c-JUN is independent of the protein's normal activity. Kollmann has now added a further twist to the tail with the discov
'/>"/>

Contact: Veronika Sexl
veronika.sexl@vetmeduni.ac.at
43-125-077-2910
University of Veterinary Medicine -- Vienna
Source:Eurekalert

Page: 1 2

Related medicine news :

1. United Nations Secretary-General Ban Ki-moon, President Bill Clinton, Launch MASSIVEGOOD, a Citizen Solution for Funding Global Health
2. Laughter Not Only Feels Good, Its Good for the Heart
3. Autism Speaks to play key roles at the 2010 International Meeting for Autism Research
4. Do toddlers pick up gender roles during play?
5. Playtime with Parents May Shape Gender Roles
6. The changing roles of 2 hemispheres in stroke recovery
7. 2 proteins play key roles in Burkitts lymphoma
8. Boston University researchers validate important roles of iPSCs in regenerative medicine
9. Enhancing arrest of cell growth to treat cancer in mice
10. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
11. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2015)... 2015 A live auction will be held ... major hospital in Brooklyn, NY and other national consignors. Various ... lab, anesthesia, exam and much more. , The auction ... starting at 9:00am CDT each day. The equipment is at ... Park, IL 60160. Anyone can participate in the auction ...
(Date:4/19/2015)... (PRWEB) April 19, 2015 Family and friends ... for Brains in Memory of Brad Baddeley event to ... Aneurysm Foundation. , Bowling for Brains is cheduled to take ... 4700 Dudley Street in Lincoln, Nebraska. Participants may arrive at ... to 3:00pm. , The cost is only $4 per game ...
(Date:4/18/2015)... New York, NY (PRWEB) April 19, 2015 ... has experienced strong growth during the past five years. ... elderly individuals who are unable to fully care for ... and the growing need for dementia care for seniors ... revenue to rise at an annualized rate of 4.1% ...
(Date:4/18/2015)... Carinsurancesavings.biz has released a new blog post explaining why ... , Spring can be a great season for ... they compare the newest policies before deciding on a ... Spring car insurance offers by reading the newly released ... more and more popular. Many insurance brokerage websites like ...
(Date:4/18/2015)... April 18, 2015 "I wanted ... to create a healthful juice that contained essential ... Rosedale, Md. "It increases my energy, improves skin ... , He developed Tapp's Juice to contain fruits, ... to prevent physical and mental fatigue. It features ...
Breaking Medicine News(10 mins):Health News:Centurion to Sell Surplus Medical Equipment in Online and On-Site Auction 2Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 2Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 3Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Auto Insurance Plans Are Cheaper During Spring! 2
... Facet Solutions, Inc. announced,today that it has ... of,patients to receive its Anatomic Facet Replacement System ... year include a significant,decline in leg and back ... Additionally, the first patient in the,AFRS(TM) study has ...
... Symbol: AKL, MONTREAL, Oct. 15 /PRNewswire-FirstCall/ - ... focused on developing therapies for the,inhalation and pain ... offering in the United States of 5,250,000 shares ... a 30-day option to purchase up to,an additional ...
... study published in the October 15 issue of the ... Adolescent Sleepiness Questionnaire (CASQ), a new self-completed instrument to ... led by James C. Spilsbury, PhD, of the Division ... on a subsample of 411 adolescents between 11-17 years ...
... US$ 65 M (About Euro 46 M),Frutarom Establishes its Position as One of ... ... Frutarom Continues to Implement Rapid Growth Strategy, ... ("Frutarom") announced today,that it has signed an agreement to acquire 100% of the ...
... in 3 Believe Nothing Can Be Done, 2 ... Risk to Well-Being, CHICAGO, Oct. 15 Nearly ... to prevent accidental injuries, posing a major,obstacle to national ... according to a national survey of American attitudes on,safety ...
... STANFORD, Calif. - One of the most distressing aspects of ... problems are the beginning of an inevitable mental decline. Researchers ... blood test that is a step toward giving people an ... of the disease. , The test identifies changes in a ...
Cached Medicine News:Health News:Facet Solution's AFRS(TM) Implant Demonstrates Positive Clinical Results After One Year Follow Up 2Health News:AKELA Pharma Inc. announces U.S. public offering and proposed listing 2Health News:New tool to assess excessive daytime sleepiness in adolescents published in JCSM 2Health News:Frutarom Acquires Gewurzmuller, a Company Specializing in Unique Savory Flavors 2Health News:Frutarom Acquires Gewurzmuller, a Company Specializing in Unique Savory Flavors 3Health News:Frutarom Acquires Gewurzmuller, a Company Specializing in Unique Savory Flavors 4Health News:Frutarom Acquires Gewurzmuller, a Company Specializing in Unique Savory Flavors 5Health News:Americans' Pessimistic View of Accident Prevention Poses Hurdle to Reducing Injuries, Survey Says 2Health News:Americans' Pessimistic View of Accident Prevention Poses Hurdle to Reducing Injuries, Survey Says 3Health News:Blood test takes step toward predicting Alzheimer's risk, Stanford researchers find 2Health News:Blood test takes step toward predicting Alzheimer's risk, Stanford researchers find 3Health News:Blood test takes step toward predicting Alzheimer's risk, Stanford researchers find 4
(Date:4/16/2015)... 2015  Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ) will ... on Wednesday, May 6, 2015, following the close of the ... conference call and live webcast on the same day at ... discuss the financial results.  To access the ... the "Investors" link.  Please log onto the webcast prior to ...
(Date:4/16/2015)... Kenneth C. Frazier , chairman and chief executive officer ... the Board of the Pharmaceutical Research and Manufacturers of America ... John J. Castellani announced that he will be retiring ... to PhRMA Board Frazier formerly held the position ... and CEO of Pfizer, Inc. Also elected were George ...
(Date:4/16/2015)... YORK , April 16, 2015 An ... additional way to generate trimers from the major HIV ... could benefit future clinical development of HIV vaccine candidates ... the critical target on the surface of HIV for ... an important platform for AIDS vaccine discovery, says ...
Breaking Medicine Technology:Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 2Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 3Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 2Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 3Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 4Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 5New Method Holds Promise for HIV Vaccine Development 2
... Corporation (Nasdaq: GNBT, www.generex.com ), the leader in ... of the mouth, today announced that it has been ... Canadian Intellectual Property Office granted Canadian Patent No. 2,401,942, ... Application". This new patent increases the number ...
... International Corporation (Nasdaq: PRXL ) announced today it ... Conference in New York.  James Winschel, Senior Vice President and ... at 11:45 a.m. ET on Tuesday, October 5, 2010. ... through the "Investors" section of PAREXEL,s website at ...
Cached Medicine Technology:Generex Awarded a New Patent in Canada for its Proprietary Buccal Drug Delivery System 2Generex Awarded a New Patent in Canada for its Proprietary Buccal Drug Delivery System 3PAREXEL International to Present at William Blair Emerging Growth Stock Conference 2
Micro-hematocrit tubes available in multiple sizes and additives for a wide range of capillary blood collection....
... The Vivid 3 system is designed ... of cardiovascular performance, and offer an even ... pediatrics and the OR. From color flow ... connectivity, the new Vivid 3 offers a ...
... 4 system is an easy-to-use, high-performance ultrasound ... your clinical practice. In effect, GE has ... a value-based combination of proven technology and ... paid heed to features praised by Vivid ...
... remote monitoring from Medtronic is changing the ... care. Using their Medtronic CareLink Monitor and ... send device information from their home or ... site, clinicians have the ability to review ...
Medicine Products: