Navigation Links
The good, the bad and the ugly: The many roles of c-JUN in cancer
Date:6/28/2011

The process of cell division is tightly regulated, as mistakes may lead to cancer. The so-called c-JUN protein has been fingered as causing tumors in both skin and liver. The group of Veronika Sexl at the University of Veterinary Medicine, Vienna, has now uncovered a surprising detail with the discovery an additional function of c-JUN's also prevents silencing of an important anti-tumor factor. The results have recently been published in the open-access journal Oncotarget.

The c-JUN protein was initially described in the late 1980s as the mammalian equivalent of a protein responsible for causing cancer in birds. Intense research in a number of labs has subsequently led to a basic understanding of how the protein works. c-JUN is a transcription factor that modifies (phosphorylates) key regulatory proteins in the cell, thereby activating or deactivating them and leading to unregulated cell division and hence cancer. It has also become clear that c-JUN acts not on its own but in conjunction with an array of further proteins that modulate its function.

Karoline Kollmann in the group of Veronika Sexl, now at the University of Veterinary Medicine, Vienna, recently discovered an additional activity of c-JUN. Together with her collaboration partners at the Medical University of Vienna and in Madrid, she showed that c-JUN can bind to the promoter of a kinase gene, known as Cdk6, thereby preventing the gene from being inactivated (by means of methylation). The result is increased activity of Cdk6, which further stimulates cell division. c-JUN only activates transcription of Cdk6 in cancer cells, where it makes the disease progress even faster. Kollmann's work was published in April in the journal Blood (2011, Vol. 117, pp. 4065-4075).

The surprising aspect of the discovery is that the "new" function of c-JUN is independent of the protein's normal activity. Kollmann has now added a further twist to the tail with the discovery that c-JUN protects not only the Cdk6 gene thereby accelerating tumour formation but also the p16 gene. p16 is a known tumour suppressor gene and its mutation or inactivation is associated with an increased risk of contracting a variety of forms of cancer. By protecting its promoter from inactivation, c-JUN seems to be helping the cells to fight the cancer.

Does this mean that the main villain of the piece is not actually as bad as we thought? Kollmann's response is fairly guarded. "I think it means that the functions of all these proteins are far more complex than we know. They all work together with many other proteins and the overall effect probably depends on a large number of factors. We have a lot more to learn before we can understand what proteins to inhibit to treat the disease."


'/>"/>

Contact: Veronika Sexl
veronika.sexl@vetmeduni.ac.at
43-125-077-2910
University of Veterinary Medicine -- Vienna
Source:Eurekalert

Related medicine news :

1. United Nations Secretary-General Ban Ki-moon, President Bill Clinton, Launch MASSIVEGOOD, a Citizen Solution for Funding Global Health
2. Laughter Not Only Feels Good, Its Good for the Heart
3. Autism Speaks to play key roles at the 2010 International Meeting for Autism Research
4. Do toddlers pick up gender roles during play?
5. Playtime with Parents May Shape Gender Roles
6. The changing roles of 2 hemispheres in stroke recovery
7. 2 proteins play key roles in Burkitts lymphoma
8. Boston University researchers validate important roles of iPSCs in regenerative medicine
9. Enhancing arrest of cell growth to treat cancer in mice
10. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
11. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... May 06, 2016 , ... The Price Agency in Birmingham, ... and assist the people of their local community. The agency pledges to select ... leaders. Their desire is to bring awareness to important local causes with fundraising ...
(Date:5/6/2016)... , ... May 06, 2016 , ... ... are scheduled to provide a unique keynote address at the 2016 Learning ... inspirational stories of five community college students. Their stories—of complicated family issues, financial ...
(Date:5/6/2016)... ... May 06, 2016 , ... Bluvault ( ... implementation service offering for global clients of Coupa ( Coupa Software ) and ... Integration Service is a key component in the suite of innovative implementation services ...
(Date:5/6/2016)... OR (PRWEB) , ... May 06, 2016 , ... Logically, ... In other seasons, when the weather is too cold, dry or hot, water on ... eyes can actually absorb moisture from the surrounding air. There’s only one problem, according ...
(Date:5/6/2016)... Atlanta (PRWEB) , ... May 06, 2016 , ... From ... provider Presence Technology will share its insights on managing Customers Engagement at ... , At SpeechTek 2016, Presence Technology will deliver a Presentation on “5 ...
Breaking Medicine News(10 mins):
(Date:5/6/2016)... , May 6, 2016  Hill-Rom Holdings, Inc. (NYSE: ... of Directors declared a fiscal year 2016 third quarter ... percent increase over the amount paid a year ago. ... record as of the close of business on June 10, ...    Hill-Rom is a leading global medical technology ...
(Date:5/5/2016)... , May 5, 2016 Endo International plc ... appointment of Douglas S. Ingram , former president of ... Todd B. Sisitsky , managing partner of TPG Capital, ... "Endo recently embarked ... complement, enhance and expand the Board,s capabilities. Doug and Todd ...
(Date:5/5/2016)... Research and Markets has announced the addition ... EU Markets"  report to their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... the current Positron Emission Tomography (PET) scanner and cyclotron install ... includes France , Germany ... and the United Kingdom . Along ...
Breaking Medicine Technology: