Navigation Links
The good, the bad and the ugly: The many roles of c-JUN in cancer
Date:6/28/2011

The process of cell division is tightly regulated, as mistakes may lead to cancer. The so-called c-JUN protein has been fingered as causing tumors in both skin and liver. The group of Veronika Sexl at the University of Veterinary Medicine, Vienna, has now uncovered a surprising detail with the discovery an additional function of c-JUN's also prevents silencing of an important anti-tumor factor. The results have recently been published in the open-access journal Oncotarget.

The c-JUN protein was initially described in the late 1980s as the mammalian equivalent of a protein responsible for causing cancer in birds. Intense research in a number of labs has subsequently led to a basic understanding of how the protein works. c-JUN is a transcription factor that modifies (phosphorylates) key regulatory proteins in the cell, thereby activating or deactivating them and leading to unregulated cell division and hence cancer. It has also become clear that c-JUN acts not on its own but in conjunction with an array of further proteins that modulate its function.

Karoline Kollmann in the group of Veronika Sexl, now at the University of Veterinary Medicine, Vienna, recently discovered an additional activity of c-JUN. Together with her collaboration partners at the Medical University of Vienna and in Madrid, she showed that c-JUN can bind to the promoter of a kinase gene, known as Cdk6, thereby preventing the gene from being inactivated (by means of methylation). The result is increased activity of Cdk6, which further stimulates cell division. c-JUN only activates transcription of Cdk6 in cancer cells, where it makes the disease progress even faster. Kollmann's work was published in April in the journal Blood (2011, Vol. 117, pp. 4065-4075).

The surprising aspect of the discovery is that the "new" function of c-JUN is independent of the protein's normal activity. Kollmann has now added a further twist to the tail with the discov
'/>"/>

Contact: Veronika Sexl
veronika.sexl@vetmeduni.ac.at
43-125-077-2910
University of Veterinary Medicine -- Vienna
Source:Eurekalert

Page: 1 2

Related medicine news :

1. United Nations Secretary-General Ban Ki-moon, President Bill Clinton, Launch MASSIVEGOOD, a Citizen Solution for Funding Global Health
2. Laughter Not Only Feels Good, Its Good for the Heart
3. Autism Speaks to play key roles at the 2010 International Meeting for Autism Research
4. Do toddlers pick up gender roles during play?
5. Playtime with Parents May Shape Gender Roles
6. The changing roles of 2 hemispheres in stroke recovery
7. 2 proteins play key roles in Burkitts lymphoma
8. Boston University researchers validate important roles of iPSCs in regenerative medicine
9. Enhancing arrest of cell growth to treat cancer in mice
10. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
11. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... Foot and Ankle Specialists of ... Leone (Pasadena and Baltimore Divisions) was recently presented ... Medical Association (MPMA) President from 2013 to 2015 at ... Doctorate in Podiatric Medicine from Temple University in 1999 ... in Voorhees, New Jersey. Dr. Leone is an ...
(Date:5/26/2015)... 2015 Pacifica Graduate Institute ... Memorial Day weekend, celebrating the outstanding accomplishments of ... picturesque Ladera Lane campus, located in the Santa ... traveled to Santa Barbara from all over the ... , The 2015 commencement ceremonies featured the traditional ...
(Date:5/26/2015)... The Brain Aneurysm Foundation is proud ... their renowned Conductor Keith Lockhart will once again team ... 10, 2015—the 4th Annual Brain Aneurysm Foundation Night ... is set to feature an exclusive Brain Aneurysm Foundation ... who tragically lost his sister-in-law to a brain aneurysm ...
(Date:5/26/2015)... 26, 2015 The professionals from Marietta ... it again, helping local rescue pets with a parking ... dentists, Kirk Kimmerling DDS, Suzanna Aguilera DMD and Garrick ... DVM donating 100% of proceeds from the extravaganza. , ... parking lot to help save unwanted, local animals. ...
(Date:5/26/2015)... Pinehurst, NC (PRWEB) May 26, 2015 ... otolaryngologists at Pinehurst Surgical Center in Pinehurst, N.C. have ... area sinus surgery patients about chronic sinusitis and the ... questionnaire that can be used to determine if someone ... asks questions about symptoms and other factors that can ...
Breaking Medicine News(10 mins):Health News:Foot and Ankle Specialists of the Mid-Atlantic, LLC Podiatrist Receives MPMA Service Award 2Health News:Pacifica Graduate Institute Hosted its 2015 Commencement Ceremonies over Memorial Day Weekend 2Health News:Pacifica Graduate Institute Hosted its 2015 Commencement Ceremonies over Memorial Day Weekend 3Health News:Boston Pops & Renowned Conductor Keith Lockhart to Join the Brain Aneurysm Foundation for the 4th Annual Brain Aneurysm Foundation Night at the Pops 2Health News:"Rescue Animal Cookout" Announced at Verde Pointe Professional Park on June 25, 2015 2Health News:Pinehurst Surgical Sinus Center Launches Pinehurst Balloon Sinuplasty Website 2
... , SANTA FE, N.M., Aug. 13 The New ... a new alliance to assist school districts with Medicaid claiming. This ... and will be administered by Accelify. , , ... NMSBA,s Executive Director. "NMSBA is focused on bringing value-added programs to ...
... 13 Select Medical Corporation ("Select") today announced results for ... For the second quarter ended June 30, 2009, ... $538.8 million for the same quarter, prior year. Income ... million for the same quarter, prior year. Net income ...
... , IRVINE, Calif., Aug. 13 ... used in the treatment of patients suffering from severe angina, today ... , , Net revenues in the second quarter ... second quarter net revenues of $4,119,000. The decrease in net ...
... Rheumatoid arthritis pain subsided when depression and inflammation ... -- Treating both depression and inflammation can reduce ... Japanese researchers say. , They studied 218 RA ... depression symptoms, year of RA onset, smoking and ...
... SAN JOSE, Calif., Aug. 13 Human Pheromone Sciences, Inc. ... the three and six months ended June 30, 2009. For the three ... 5% decrease from the revenues of $236,000 in the prior year period, ... compared with a net loss of $88,000 ($0.02 per share) for the ...
... , , NEW YORK, Aug. 13 ... to fight obesity and its consequences. Chef Lindsey Williams, grandson of ... author of " Neo Soul ," a collection of traditional soul food ... a series of breakfast smoothies named after iconic Harlem figures this weekend ...
Cached Medicine News:Health News:New Mexico School Boards Association and Accelify Announce Alliance to Assist New Mexico Schools 2Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 2Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 3Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 4Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 5Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 6Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 7Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 8Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 9Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 10Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 11Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 12Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 13Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 14Health News:Select Medical Corporation Announces Results for Second Quarter Ended June 30, 2009 15Health News:Cardiogenesis Reports Second Quarter 2009 Results 2Health News:Cardiogenesis Reports Second Quarter 2009 Results 3Health News:Cardiogenesis Reports Second Quarter 2009 Results 4Health News:Cardiogenesis Reports Second Quarter 2009 Results 5Health News:Cardiogenesis Reports Second Quarter 2009 Results 6Health News:Cardiogenesis Reports Second Quarter 2009 Results 7Health News:Treat Mind, Body in RA Patients: Study 2Health News:Human Pheromone Sciences Announces Second Quarter Results 2Health News:Human Pheromone Sciences Announces Second Quarter Results 3Health News:Human Pheromone Sciences Announces Second Quarter Results 4Health News:Queen of Soul Food's Grandson on Mission to Get Harlem Kids to Eat Healthier 2Health News:Queen of Soul Food's Grandson on Mission to Get Harlem Kids to Eat Healthier 3
(Date:5/22/2015)... 2015  In a sweeping analysis assessing the current ... Exchange researchers conclude that there remains considerable room ... all age groups, but especially for adolescents and young ... diabetes treatment, underscoring the need to address barriers to ... help type 1 patients achieve optimal metabolic control. ...
(Date:5/22/2015)... 22, 2015  China Nepstar Chain Drugstore Ltd. (NYSE: ... drugstore chain in China based ... the resignation of Mr. Fuxiang Zhang as ... immediately. Ms. Rebecca Yingnan Zhang has been ... of directors, effective immediately. Meanwhile, Ms. Zhang resigned from ...
(Date:5/21/2015)... 21, 2015 Research and ... of the "North American Active Wound Care ... (Surgical Wound, & Ulcer), by End-User (In-Patient, & ... report to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... estimated to grow at a CAGR of 3.1% ...
Breaking Medicine Technology:Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 2Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 3Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 4Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 5China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 3North American Active Wound Care Market 2015-2019 with Smith and Nephew, Molyncke HealthCare & ConvaTec Dominating 2
... Waltham, Mass., June 7, 2007 – Dynogen Pharmaceuticals,Inc. ... 1b trial of DDP733 for gastroesophageal,reflux disease (GERD). ... DDP733 as a treatment for nocturnal GERD,(NGERD). ... statistical,significance over placebo on the primary endpoint of ...
... 2007 - AVANIR,Pharmaceuticals (NASDAQ:AVNR) today announced ... efficacy, safety and improvements in,patient-centered outcomes ... pain treated with the investigational drug,Zenvia(TM) ... sigma-1 agonist. The data were accepted ...
Cached Medicine Technology:Dynogen's DDP733 Reduces Reflux in Phase 1b GERD Study 2Dynogen's DDP733 Reduces Reflux in Phase 1b GERD Study 3AVANIR Pharmaceuticals Presents Zenvia Phase III Data in Diabetic,Peripheral Neuropathic Pain at International Congress on,Neuropathic Pain 2AVANIR Pharmaceuticals Presents Zenvia Phase III Data in Diabetic,Peripheral Neuropathic Pain at International Congress on,Neuropathic Pain 3AVANIR Pharmaceuticals Presents Zenvia Phase III Data in Diabetic,Peripheral Neuropathic Pain at International Congress on,Neuropathic Pain 4AVANIR Pharmaceuticals Presents Zenvia Phase III Data in Diabetic,Peripheral Neuropathic Pain at International Congress on,Neuropathic Pain 5AVANIR Pharmaceuticals Presents Zenvia Phase III Data in Diabetic,Peripheral Neuropathic Pain at International Congress on,Neuropathic Pain 6AVANIR Pharmaceuticals Presents Zenvia Phase III Data in Diabetic,Peripheral Neuropathic Pain at International Congress on,Neuropathic Pain 7
Inquire...
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
This is a single-action instrument that features a spring handle....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
Medicine Products: