Navigation Links
The good, the bad and the ugly: The many roles of c-JUN in cancer
Date:6/28/2011

The process of cell division is tightly regulated, as mistakes may lead to cancer. The so-called c-JUN protein has been fingered as causing tumors in both skin and liver. The group of Veronika Sexl at the University of Veterinary Medicine, Vienna, has now uncovered a surprising detail with the discovery an additional function of c-JUN's also prevents silencing of an important anti-tumor factor. The results have recently been published in the open-access journal Oncotarget.

The c-JUN protein was initially described in the late 1980s as the mammalian equivalent of a protein responsible for causing cancer in birds. Intense research in a number of labs has subsequently led to a basic understanding of how the protein works. c-JUN is a transcription factor that modifies (phosphorylates) key regulatory proteins in the cell, thereby activating or deactivating them and leading to unregulated cell division and hence cancer. It has also become clear that c-JUN acts not on its own but in conjunction with an array of further proteins that modulate its function.

Karoline Kollmann in the group of Veronika Sexl, now at the University of Veterinary Medicine, Vienna, recently discovered an additional activity of c-JUN. Together with her collaboration partners at the Medical University of Vienna and in Madrid, she showed that c-JUN can bind to the promoter of a kinase gene, known as Cdk6, thereby preventing the gene from being inactivated (by means of methylation). The result is increased activity of Cdk6, which further stimulates cell division. c-JUN only activates transcription of Cdk6 in cancer cells, where it makes the disease progress even faster. Kollmann's work was published in April in the journal Blood (2011, Vol. 117, pp. 4065-4075).

The surprising aspect of the discovery is that the "new" function of c-JUN is independent of the protein's normal activity. Kollmann has now added a further twist to the tail with the discov
'/>"/>

Contact: Veronika Sexl
veronika.sexl@vetmeduni.ac.at
43-125-077-2910
University of Veterinary Medicine -- Vienna
Source:Eurekalert

Page: 1 2

Related medicine news :

1. United Nations Secretary-General Ban Ki-moon, President Bill Clinton, Launch MASSIVEGOOD, a Citizen Solution for Funding Global Health
2. Laughter Not Only Feels Good, Its Good for the Heart
3. Autism Speaks to play key roles at the 2010 International Meeting for Autism Research
4. Do toddlers pick up gender roles during play?
5. Playtime with Parents May Shape Gender Roles
6. The changing roles of 2 hemispheres in stroke recovery
7. 2 proteins play key roles in Burkitts lymphoma
8. Boston University researchers validate important roles of iPSCs in regenerative medicine
9. Enhancing arrest of cell growth to treat cancer in mice
10. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
11. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 Deer Path of ... host a Valentine’s Day Happy Hour from 3 p.m. to 4 ... 12500 Regency Parkway in Huntley, Illinois, serves adults with physical disabilities ... event will include Valentine's Day treats, games and sweetheart-themed karaoke. , ...
(Date:1/22/2015)... its top dressmaking technologies, has been a leading dress supplier ... latest designs of wedding dresses and launching a site-wide promotion ... the fresh new products are designed for 2015, and they ... All the clothes from LunaDress follow up with the latest ...
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the release of ... kids with cancer. The Chemo Duck App, available on iTunes for ... games to help children of all ages living with cancer adjust ... kids entertained, educated and at ease while waiting for clinic visits ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 The Incredible ... Bodybuilder Ben Pakulski to increase lean muscle by up to ... has caught the attention of HealthyandFitZone.com’s Stan Stevenson, prompting an ... that it is a step-by-step, scientific diet formula that allows ...
(Date:1/22/2015)... the premier women’s dress supplier, has recently released its ... of AngelWeddingDress.com to find more details. , Many ... a bridal party. AngelWeddingDress offers a variety of gorgeous ... wedding dresses are specially designed for 2015. , AngelWeddingDress ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... 2, 2008, New York, NYA new report from The ... in the health system reform proposals of presidential candidates ... report, The 2008 Presidential Candidates, Health Reform Proposals: Choices ... to expand health insurance, but Senator McCain would encourage ...
... Agency for,Healthcare Research and Quality has awarded nearly ... line-associated bloodstream infections in,hospital intensive care units (ICUs) ... project. The Health Research & Educational Trust, an,affiliate ... to,coordinate the new 3-year project, which is part ...
... MHA Keystone: ICU Patient Safety Program, LANSING, ... and Quality (AHRQ) today announced a three-year, $3 ... infections,in intensive care units (ICUs)., This first-of-its-kind ... Michigan Health & Hospital Association,s (MHA) Keystone Center ...
... Calif., Oct. 1 BioForm Medical,Inc. (Nasdaq: BFRM ... at the,2008 Maxim Group Growth Conference on Tuesday, October ... is scheduled to,provide a corporate overview of the Company ... audio portion of the presentation will be webcast live ...
... Deployed peacekeeping veterans with post traumatic stress disorder (PTSD) ... to research by Dr. J. Donald Richardson of The ... research, published this month in the Canadian Journal ... are associated with impaired emotional well-being, and this applies ...
... parents of gravely ill newborns , , WEDNESDAY, Oct. 1 ... for parents is deciding on a course of action ... extremely prematurely or with potentially fatal or disabling problems. ... end-of-life care are key. Yet, few result in satisfaction ...
Cached Medicine News:Health News:Presidential candidates' health plans offer divergent approaches to health system reform 2Health News:Presidential candidates' health plans offer divergent approaches to health system reform 3Health News:Presidential candidates' health plans offer divergent approaches to health system reform 4Health News:AHRQ Awards $3 Million to Help Reduce Central Line-Associated Bloodstream Infections in Hospital ICUs 2Health News:Michigan Success Lands National Research Contract to Reduce Hospital-Associated Infections in 10 States 2Health News:BioForm Medical to Present at the 2008 Maxim Group Growth Conference 2Health News:Whether combat or peacekeeping, PTSD impacts veterans' well-being 2Health News:Hard Decisions for the Littlest Lives 2Health News:Hard Decisions for the Littlest Lives 3
(Date:1/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ) ... Market (Indwelling or Foley Catheters, Intermittent Catheters and Male ... Share, Growth, Trends and Forecast 2014 - 2020" ... present, the global market for urinary catheters is experiencing ...
(Date:1/23/2015)... 23, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO )("NW ... for operable and inoperable solid tumor cancers, announced today that ... th Annual Phacilitate Immunotherapy Forum in Washington ... will take place on January 26 at 10:30 a.m. EST ...
(Date:1/23/2015)... , Jan. 23, 2015  Immune Therapeutics, Inc. today announced the ... the compounding, packaging and distributing of its naltrexone tablets.  The ... United States . KRS Global is ... tablets in various strengths for individual patients in response to ...
Breaking Medicine Technology:Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: