Navigation Links
The genome guardian's dimmer switch: Regulating p53 is a matter of life or death
Date:6/30/2011

iation, without raising the long-term cancer risk to unacceptable levels.

Scientists therefore are eager to find out how cells naturally regulate p53, so that they can target these mechanisms with drugs. One clue uncovered by recent studies is that regulatory molecules can alter p53 activity by chemically modifying some key amino acids. In the current study, Wahl and colleagues set out to illuminate the function of a stretch of regulatory amino acids at one end of the protein by creating "designer" mice with other amino acids in this region, thereby rendering it inoperative.

The mutant mice had somewhat higher p53 activity than normal mice, at least in some tissues. Based on other studies, Wahl's team expected the mutants to age faster. To their surprise, however, the mutant mice lived about as long as ordinary, "wild type" mice. A second surprise came when Wahl's team exposed the mice to ionizing radiation, of the sort that nuclear power plants may emit. While all the normal mice survived, half the mutant mice died within four weeks.

To understand why the mutant mice died so readily, Vivian Wang, a postdoc in Wahl's lab, collaborated with the Salk veterinarian, Mat Leblanc, and hematologists at UCSD and noted that the irradiated mutant mouse hearts became enlarged and pale, as if they had been starved of oxygen. "Eventually, we found the reason for this," Wahl explains. "We found that irradiation and the ensuing p53 response significantly damaged the blood-forming cells of their bone marrow, but other parts of their bodies seemed quite normal. We followed up these studies with stem cell transplantation experiments to show the mutant p53 really affected the stem cells and their descendents that make the blood."

These results led the team to conclude that the loss of function of p53's normal "dimmer-switch" segment had allowed the protein to become too active in the hematopoietic stem cells of the mutant mice, arresting the ste
'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. GenomeQuest Hosts Seminar Focused On Web-based Searching for Patent Information Across Global Sequence Databases
3. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
4. Mayo oral cancer study shows full tumor genome
5. Entire Family Genome Sequenced for First Time
6. Medicines Future Could Lie in Each Patients Genome
7. Human Genome Turns 10
8. Genome Sequencing Reveals How Breast Cancer Spreads
9. Patients whole genome reveals risk of diseases and adverse drug responses
10. Genome Scan Gives Man Insight Into Future Health Risks
11. Genome breakthrough allows scientists to identify and profile tumor cells from very small samples
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... (PRWEB) April 20, 2015 Novatus, ... has further expanded its service level to the ... locations in Amsterdam and Paris. After a ... their sophisticated levels of resilience, security and operational ... major milestone for Novatus as we expand our ...
(Date:4/20/2015)... April 20, 2015 Early registration is ... and secure your space at the start line. Returning ... Olympic-distance race is limited to 500 participants (actually there’s only ... secured his spot). , Now thru April 30, the entry ... team members; after May 1st, the fee goes up to ...
(Date:4/20/2015)... Hills, CA (PRWEB) April 20, 2015 Genuine ... have tried diets and gym memberships in the past. But ... weight loss results can be guaranteed by adhering to ... a bad diet. No matter how many hours one spends ... all efforts to lose weight., But a nutritional mean plan ...
(Date:4/20/2015)... “ Verus ” was featured on NewsWatch as ... latest and coolest technology products available to consumers. Scott ... conducted the review and shared with viewers how Verus ... According to CNET, at least a quarter of iPhone ... that smartphones break so easily, but at least they ...
(Date:4/20/2015)... CA (PRWEB) April 20, 2015 Grateful ... and were united as one until 1995. The group was ... including blues, reggae, rock, bluegrass, folk, space rock, country, and ... known as the ultimate jam band. The group was inducted ... and in total has sold more than 35 million records ...
Breaking Medicine News(10 mins):Health News:Novatus Expands into European Data Centers 2Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 2Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 3Health News:Guarantee Fat Loss Results With 5 Easy Tips 2Health News:Guarantee Fat Loss Results With 5 Easy Tips 3Health News:Attractive and Durable Phone Cases were Featured on NewsWatch Television 2Health News:Grateful Dead Tickets at Levi’s Stadium in Santa Clara: Ticket Down Slashes Grateful Dead Tickets in Santa Clara @ Levi’s Stadium for "Fare Thee Well" 50th Anniversary 2
... almost a 80% chance of winning a battle with cancer, ... cancer 20 to 30 years ago.// A recent report ... cancer, this does not absolve them from the risks of ... the co-authors of the Childhood Cancer Survivor Study is a ...
... of traditional medicines that they say is being thwarted ... ,Mei Zhinan, an expert in traditional ethnic medicines ... percent of China's 55 minority groups, accounting for up ... had their own traditional medicines and secret formulas handed ...
... virus appears to be fast engulfing Uttar Pradesh's capital with ... 31 dengue-positive cases admitted to various government hospitals in the ... Nigam, the spokesman of the state health department, told IANS. ... had risen particularly over the past four days, taking the ...
... accredited NewYork-Presbyterian Hospital as a Bariatric Surgery Center Network ... recognition of the Hospital's ability to offer patients the ... for New York state and one of only seven ... 20 years of age and older are obese -- ...
... diabetes also have periodontal disease, according to research released ... over one in ten pregnant women without gestational diabetes ... issue of the American Journal of Obstetrics and Gynecology, ... oral health and diabetes during pregnancy. ,Periodontal disease ...
... by S. Kankova and colleagues from the Departments of ... Reproductive Medicine; and GynCentrum, in the Czech Republic, women ... than women who are Toxoplasma negative. // ... in human with a universal occurrence of 20-80%. This ...
Cached Medicine News:Health News:Childhood Cancer Survivors May Suffer Health Problems in Adulthood 2Health News:Chinese Experts Call for Protection of Traditional Medicines 2Health News:NewYork-Presbyterian Receives Highest Accreditation for Bariatric Surgery 2Health News:Effect of parasitic infection on baby's sex 2
(Date:4/20/2015)... , April 20, 2015   Gateway ... Research and Training Institute today expanded its Naloxone: ... outpatient locations.  A $50,000 grant from the ... research project possible.  The yearlong ... to patients and their family members upon completion ...
(Date:4/20/2015)... 2015  Purdue Pharma, a leading specialty pharmaceutical ... has joined the company as Senior Vice President ... responsibility for all of Purdue,s efforts to acquire ... would benefit from our patient-focused commercial capabilities. ... Purdue President & CEO Mark Timney . ...
(Date:4/20/2015)... 2015 Cardinal Innovations Healthcare Solutions ... high-tech, high-touch service delivery, is featuring its highly ... the National Council for Behavioral Health,s annual National ... 20–22, 2015, at the Gaylord Palms Resort and ... , attracts participants from mental health and addiction ...
Breaking Medicine Technology:Gateway Rehab and the Kenneth S. Ramsey, PhD Research and Training Institute expand Naloxone: Increasing Access, Saving Lives research project to outpatient locations 2Gateway Rehab and the Kenneth S. Ramsey, PhD Research and Training Institute expand Naloxone: Increasing Access, Saving Lives research project to outpatient locations 3Purdue Pharma Names J. Alan Butcher Senior Vice President of Licensing & Business Development 2Cardinal Innovations Highlights its Managed Care Model During National Council for Behavioral Health's Annual Conference 2Cardinal Innovations Highlights its Managed Care Model During National Council for Behavioral Health's Annual Conference 3
... , July 15 Caraco Pharmaceutical Laboratories, Ltd. (NYSE ... , NYSE Amex notified the Company that it was not in ... audit committee be comprised of three independent members. On July ... with Section 803(B)(2)(a) of NYSE Amex Company Guide following the resignation ...
... SAN DIEGO , July 15 ... HealthCare has selected the Allscripts Community Record , provided ... across the health system. Using the Allscripts solution, Sharp,s caregivers ... to a single, unified patient record, bridging gaps that often ...
Cached Medicine Technology:Caraco Pharmaceutical Laboratories, Ltd. Receives Notice Regarding NYSE Amex Continued Listing Standards 2Sharp HealthCare Selects Allscripts Community Record to Deliver End-to-End Health Information Connectivity for San Diego Physicians and Hospitals 2Sharp HealthCare Selects Allscripts Community Record to Deliver End-to-End Health Information Connectivity for San Diego Physicians and Hospitals 3Sharp HealthCare Selects Allscripts Community Record to Deliver End-to-End Health Information Connectivity for San Diego Physicians and Hospitals 4Sharp HealthCare Selects Allscripts Community Record to Deliver End-to-End Health Information Connectivity for San Diego Physicians and Hospitals 5Sharp HealthCare Selects Allscripts Community Record to Deliver End-to-End Health Information Connectivity for San Diego Physicians and Hospitals 6
Bipolar semi-floating pacing lead for temporary stimulation of the heart especially in emergency cases of bradycardial arrhythmias or for recording intracardiac ECGs....
Bipolar semi-floating pacing lead for temporary stimulation of the heart especially in emergency cases of bradycardial arrhythmias or for recording intracardiac ECGs....
Bipolar semi-floating pacing lead for temporary stimulation of the heart especially in emergency cases of bradycardial arrhythmias or for recording intracardiac ECGs....
Permanent, sutureless, epicardial pacing leads...
Medicine Products: