Navigation Links
The genome guardian's dimmer switch: Regulating p53 is a matter of life or death
Date:6/30/2011

LA JOLLA, CA Scientists at the Salk Institute for Biological Studies have found clues to the functioning of an important damage response protein in cells. The protein, p53, can cause cells to stop dividing or even to commit suicide when they show signs of DNA damage, and it is responsible for much of the tissue destruction that follows exposure to ionizing radiation or DNA-damaging drugs such as the ones commonly used for cancer therapy. The new finding shows that a short segment on p53 is needed to fine-tune the protein's activity in blood-forming stem cells and their progeny after they incur DNA damage.

"It's like a dimmer switch, or rheostat, that helps control the level of p53 activity in a critical stem cell population and the offspring they generate," says Geoffrey M. Wahl, professor in the Salk Institute's Gene Expression Laboratory, and senior author of the study, which appears online in the journal Genes & Development on July 1, 2011. "In principle, controlling this switch with drugs could reduce the unwanted effects from DNA-damaging chemotherapy or radiation treatment, allowing higher doses to be used."

The protein p53 is an important tumor suppressor because it can destroy or halt the growth of cells that develop potential cancer-causing DNA mutations. But as Wahl's lab and others have shown over the past several years, p53 has much broader importance in the life and death of cells. "It's critical for determining whether a cell survives stress and continues to function in a variety of situations," says Wahl.

One problem with p53 is that it apparently evolved to protect the integrity of the genome for future generations, rather than to prolong the lives of individual cells or animals. From the point of view of an animal, p53 sometimes goes too far in killing cells or suppressing growth. Experiments in mice have suggested that even modest reductions in p53's activity greatly increases survival after exposure to rad
'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. GenomeQuest Hosts Seminar Focused On Web-based Searching for Patent Information Across Global Sequence Databases
3. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
4. Mayo oral cancer study shows full tumor genome
5. Entire Family Genome Sequenced for First Time
6. Medicines Future Could Lie in Each Patients Genome
7. Human Genome Turns 10
8. Genome Sequencing Reveals How Breast Cancer Spreads
9. Patients whole genome reveals risk of diseases and adverse drug responses
10. Genome Scan Gives Man Insight Into Future Health Risks
11. Genome breakthrough allows scientists to identify and profile tumor cells from very small samples
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 23, 2015 Angelweddingdress is a famous wedding ... its customers to follow it on Facebook, Twitter, and Pinterest. ... Day gift. Angelweddingdress draws a lottery every week. , Moreover, ... Feb. 28, 2015. Click Angelweddingdress homepage for more ...
(Date:1/22/2015)... 2015 A new white paper by ... person-centeredness in the long-term care environment as well as ... continuum. The paper, “The Power of Person-Centeredness in Long-Term ... practices of the patient, resident and family experience in ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved television ... 32nd Annual Miami Breast Cancer Conference planned ... (PER®) , shares that “a fast-growing, virulent” cancer in ... had not followed up her clean mammogram with an ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Four years since the ... – which coincided with the marriage of Avasa & Matthew Love ... ROAD, which is scheduled for release through White Swan Records on ... that there is a sacred path available to all of us ...
(Date:1/22/2015)... has released a new blog post presenting a list of vehicles ... , Some types of vehicles cannot be covered under an ... post to see if their vehicle qualifies for auto insurance coverage. ... the cars that cannot be covered by a plan. Clients have ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... A new study shows that the prevalence of hay fever ... allergic reactions have risen sharply.// ,In the research ... the scientists at the University of Edinburgh have said that ... stabilised, after many years of steady rise but at the ...
... have the unique property or reducing the risk of Alzheimer's disease, ... people in the study, which appears in the latest issue of ... the risk of Alzheimer's was reduced by as much as 76 ... week as compared to those who drank fruit juices only about ...
... The discovery that humans are genetically more suited to being ... discussed in Queenstown// conference by more then 300 leading scientists ... human cell and finding a cure for cancer is also ... Jeremy Hyams, the Convener of the conference says the finding ...
... in the shirt drawer, the time-honored lessons of helping organize ... brain are used to encode such categories as socks, shirts, ... place? ,New research from Harvard Medical School (HMS) investigators ... are found. They report in the advanced online Nature that ...
... North high school, 500 will undergo testing this week following ... will be tested in the coming weeks. ,A ... laboratory tests have now confirmed the boy has tuberculosis. ... parents revealed exposure to the infecting bacteria. The remaining students ...
... the counter but the FDA may soon change that.The FDA ... contain hydroquinone because studies in rats show the possibility that ... of Massachusetts General Hospital said, "I think the FDA is ... the data to show this is not a concern and ...
Cached Medicine News:Health News:Eczema And Hay Fever Decline In UK While Allergic Reactions On The Rise 2Health News:Brain's Filing System Uncovered 2Health News:Brain's Filing System Uncovered 3
(Date:1/23/2015)... Inc. (ICBU) has repositioned itself as a holding company with ... in the hydroponic, hemp and medical marijuana sectors. By acquiring ... sector, and recently partnering with the Chippewa Tribe Nation to ... iMD is committing to bring its vision to the market ...
(Date:1/23/2015)... 2015   Leatt Corporation  (OTCQB: LEAT), a global developer, ... forms of sports, including extreme motor sports, and whose ... that the UISP Lega Motociclismo Lombardia, an Italian motocross ... wear a neck brace during its racing competitions.  ...
(Date:1/23/2015)... , Jan. 23, 2015 Gem Pharmaceuticals announced today ... been enrolled into the Company,s Phase 2 clinical trial. ... of Gem,s lead compound, GPX-150 (an investigational medication), in ... metastatic disease. Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
Breaking Medicine Technology:iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2
... Medical Group,s (FMG) subsidiaries, VasoStar Inc., Mentor, Ohio  today ... Frontier grant to further develop and commercialize a novel ... Occlusions (CTOs), in lieu of invasive open heart surgery ... VasoStar,s primary clinical development partner is the Cleveland ...
... July 20, 2011 Advanced Health Media (AHM), the ... solutions for the pharmaceutical industry, has named James Burgess ... assumes responsibility from Jeff Brady who has served as ... as its President for 9 years. James brings over ...
Cached Medicine Technology:Frantz Medical Group Subsidiary, VasoStar, Awarded $1 Million Research Grant 2Frantz Medical Group Subsidiary, VasoStar, Awarded $1 Million Research Grant 3Advanced Health Media Announces New CEO 2
Part of the Octopus System which includes both the Starfish & Octopus3. The Starfish Heart Positioner simplifies cardiac positioning and minimizes the associated hemodynamic deterioration when compa...
... Guidant's fourth generation access device - XPOSE ... the heart. The XPOSE 4 Device is ... off-pump bypass surgery and to easily position ... Designed for both apical and non-apical placement ...
... SUV vacuum stabilizer from Guidant. ... of use. The newest members of the ... with outstanding anastomotic site visibility and ... FlexLink technology on a stronger arm, ...
... ABIOMED's BVS 5000 has grown to become the ... the world to support recoverable hearts. It is ... and Drug Administration for all patients with potentially ... advances with the BVS 5000, expanding the patient ...
Medicine Products: