Navigation Links
The genetic key to conquering cholera
Date:7/19/2013

Researchers have long understood that genetics can play a role in how susceptible people are to contracting cholera, but a team of Harvard scientists is now uncovering evidence of genetic changes that might also help protect some people from contracting the deadly disease.

Based on genetic data gathered from hundreds of people in Bangladesh, a research team made up of Harvard faculty and scientists from the Broad Institute and Massachusetts General Hospital were able to a number of areas in the genome some of which are responsible for certain immune system functions, while others are related to fluid loss that appear to be related to cholera resistance. Later tests showed genetic differences between people who had contracted the disease and those who had been exposed, but did not become ill. Their results are described in a paper published earlier this month in Science Translational Medicine.

"This study is exceptionally exciting for us because it shows the power of this approach," said Associate Professor of Organismic and Evolutionary Biology Pardis Sabeti, one of two senior co-authors of the paper. "This is the first time we've taken a genomic-wide approach to understanding cholera resistance. But it's a first step, and there is a lot of exploration to go from here. For a disease that's so ancient and widespread there's very little that's known about host immunity."

The hope, Sabeti added, is that by better understanding why some people appear to be immune, it will help in our efforts to develop vaccines and therapies, so outbreaks like those that occurred in recent years in Haiti and Africa might one-day be avoided.

"It is a very scary disease," she said. "We now have treatments with oral rehydration therapy, but it is still devastating, and in extreme cases, cholera can kill in hours."

"We also haven't been able to develop a particularly effective vaccine," added Elinor Karlsson, a Post-Doctoral Fe
'/>"/>

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Understanding Genetically Modified Organisms Article and Video Published by Health News Wires
2. Even healthy-looking smokers have early cell damage which destroys necessary genetic programming
3. Genetic Testing Market 2012-2016 - Global Genetic Testing Industry Share, Size,Trends, Analysis, Growth And Forecast Research Report To 2016
4. Exposure to stress even before conception causes genetic changes to offspring
5. Epigenetic changes to fat cells following exercise
6. Moms often talk to children about the results of cancer genetic testing
7. Genetics of cervical cancer raise concern about antiviral therapy in some cases
8. Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
9. Yale researchers unravel genetics of dyslexia and language impairment
10. Genetic variations may help identify best candidates for preventive breast cancer drugs
11. Mount Sinai researchers provide 1st prospective characterization of a genetic subtype of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 2014 “ SmileStix ” was featured on ... latest and coolest mobile applications on the iOS, Android, and ... of NewsWatch, conducted the app review and shared with viewers ... stickers. , The old saying goes, “A picture says a ... that can describe a single image, because each picture holds ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those ... During the holiday season, AlignLife looks forward to their annual ... Dr. Sara Mahalko-Leonhardt, owner of AlignLife. "It brings our patients ... we are able to give kids toys for Christmas who ... the generosity of our patients." , The 70 toys were ...
(Date:12/24/2014)... New York, New York (PRWEB) December 24, 2014 ... continue to mount in a mass tort litigation currently ... Liebhard LLP reports. As of December 24, 2014, ... in the proceeding on behalf of individuals who developed ... to its use. Data from the Court indicates that ...
(Date:12/24/2014)... December 25, 2014 Today, Yunx.co.uk, a ... evening dresses and other special occasion outfits, unveils ... models are offered at discounted prices, up to 80% ... young ladies with their fashionable designs, gorgeous looks and ... exception. The business is devoted to designing and offering ...
(Date:12/24/2014)... holidays can be a challenge for people who suffer migraines, ... "This is the season in which many people overindulge ... Dodick, chair of the American Migraine Foundation, said in a ... through food and beverage choices, to help reduce the risk ... neurology at the Mayo Clinic in Scottsdale, Ariz. , , ...
Breaking Medicine News(10 mins):Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Yunx.co.uk Unveils 65 New Bridesmaid Dresses for the UK market 2Health News:Expert Offers Tips for Preventing Holiday Migraines 2
... Board: NZYM) today announced financial results for its fiscal fourth quarter ... , For the fourth quarter ended March 31, 2009, revenue ... for the same period last year. Gross income for the ... million for the same period last year. Operating income for ...
... , June 3 IMAGINE Software, ... its newest features implemented within the IMAGINEradiology(TM) practice management ... 19-21. , , The ... that allows for easy deployment and maintenance distribution through ...
... Calif., June 3 Ambry Genetics is pleased to ... offering the Ambry CMA: 105K Oligo Array, which is ... genetic disorders. In a partnership with Baylor ... provide one of the most comprehensive, clinically-validated genetic tests ...
... Year-Old USAID/State Department/Private Sector Initiative Unveils Initial Aid ... Chiles and CAFAmerica,s Saxon-Harrold Report on Progress. ... One Woman Initiative ( http://www.OneWomanInitiative.org ), a one-year-old ... significant Muslim populations, today announced its first grants, ...
... An innovative University of Georgia graduate program in ... to work with elementary-age students with autism over the ... federal grant to train teachers to work with similarly ... disability that is part of a group known as ...
... blood cells to injury site, research shows , WEDNESDAY, ... to prevent infection in cuts and scrapes -- also may ... , U.S. researchers have discovered that when the tail fins ... is released from the wound and into the surrounding tissue. ...
Cached Medicine News:Health News:Synthetech Announces Fiscal 2009 Results 2Health News:Synthetech Announces Fiscal 2009 Results 3Health News:Synthetech Announces Fiscal 2009 Results 4Health News:Synthetech Announces Fiscal 2009 Results 5Health News:Synthetech Announces Fiscal 2009 Results 6Health News:IMAGINE Software Unveils Advanced IMAGINEradiology(TM) Features 2Health News:'Ambry Genetics Announces Launch of Chromosomal Microarray to Offer Whole Genome Analysis' 2Health News:'Ambry Genetics Announces Launch of Chromosomal Microarray to Offer Whole Genome Analysis' 3Health News:'One Woman Initiative' Announces First Grants to Women's Organizations in Five Nations 2Health News:'One Woman Initiative' Announces First Grants to Women's Organizations in Five Nations 3Health News:'One Woman Initiative' Announces First Grants to Women's Organizations in Five Nations 4Health News:UGA grad program expands to prepare teachers to work with secondary students with autism 2Health News:UGA grad program expands to prepare teachers to work with secondary students with autism 3Health News:Key to Wound-Healing May Be Explained in Fish Tail 2
(Date:12/24/2014)... , December 24, 2014 ... Report on Global Disposable Syringe Industry of ... its online business intelligence library. ... Disposable Syringe Industry is a professional and ... market.  For overview analysis, the report introduces ...
(Date:12/24/2014)... ALEXANDRIA, Va. , Dec. 23, 2014 /PRNewswire-USNewswire/ ... stringent diastolic blood pressure target for people with ... either moderate or high doses of statins, in ... risk management enacted by the American College of ... recommendations are reflected in the most recent changes ...
(Date:12/24/2014)... , Dec. 23, 2014  Medical Science Liaisons ... the key link between the medical device industry and ... more in the coming years as the device industry ... According to research by benchmarking firm, Best Practices, ... gain an important edge is by harnessing new technology ...
Breaking Medicine Technology:World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... Compressor provides effective therapy at an affordable price. ... home or on the go and features ease ... reliable operation you have come to count on ... the perfect solution for those patients seeking a ...
... delivery is an important part of managing ... and convenient products mean delivering the aerosolized ... time while minimizing medication waste. Aerosol delivery ... line of Nebulizers, including the new NebuTech® ...
... SynergyPlus+ is recommended for people with low ... limbs associated with failed back syndrome, low ... people with post laminectomy pain, multiple back ... disease and Complex Regional Pain Syndrome (CRPS). ...
Whether you require high flow rates for critical situations or lower rates for others, this insufflator handles both situations equally well, regulated by the preselected pressure....
Medicine Products: