Navigation Links
The genes involved in rheumatoid arthritis identified
Date:9/6/2007

The human genome has now been thoroughly screened in the hunt for the genetic causes of rheumatoid arthritis. The results, which both confirms previous hypotheses and turn the spotlight on entirely new genes, are presented in two articles in the prestigious New England Journal of Medicine.

Rheumatoid arthritis is the most common rheumatic disease, and affects approximately one per cent of the population. Its causes are unknown, but scientists believe that the chances of developing the disease are determined as much by genetic factors as they are by environment and lifestyle.

An international team of researchers from Sweden, the USA and Singapore, led by professors Lars Klareskog and Lars Alfredsson at the Swedish medical university Karolinska Institutet together with PhD group leader Mark Seielstad at the A*STAR funded national Genome Institute of Singapore, has compared the genomes of over 1,5000 rheumatics with those of 1,850 controls. Their analysis shows that the DNA of these two groups are at a variance at three sites, two genes previously linked to the disease and a previously unresearched gene complex known as TRAF-C5.

The Swedish and American researchers have also used the same material to examine the significance of a specific area of the genome. They found that yet another gene, STAT 4, could be linked to the disease.

The previously studied genes and the newly discovered TRAF-C5 and STAT4 genes are each important in its own way for the function of the bodys immune cells.

Its exciting that weve found new, single genes that impact on the risk of disease, but whats most important is that weve now got a broader base for understanding the mechanisms behind the development and course of the disease, says Professor Klareskog. Since the two most crucial genes are already known, this shows that were on the right track.

The studies illustrate the apparent need and growing trend towards conducting genetic research through large-scale international partnerships. Swedens unique patient register has been of use here for the gathering of samples and for the analysis of the interaction between genetic and environmental factors, while the genetic analysis has been carried out in Singapore using the very latest genomic techniques.

Were concentrating our efforts onto Singapore as its a country that is currently investing very actively in bioscience and biotechnology, says Professor Jan Carlstedt-Duke, Dean of Research at Karolinska Institutet. This is the second study from our partnership with Singapore thats given results.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Cirrhosis linked to genes
5. Altering genes through calories
6. Predictable genes
7. Birth weight may be influenced by genes
8. Cardiac Valve Disease Linked To Genes
9. Genes for Vision discovered
10. Endometriosis coalesced with genes
11. New breast cancer genes discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... 2017 , ... After months of negotiations, FaceCradle USA is proud to announce the debut of ... , “Introducing our product on QVC is something we all worked hard to achieve for ... more than 90 million homes in the United States,” said FaceCradle USA President Dylan Doherty. ...
(Date:6/20/2017)... ... 20, 2017 , ... Hayes, Inc., a leading provider of ... “ 5 Questions to Ask Before Entering the Maze of Genetic Testing .” ... (GTE) team, the book explores the various types of the more than 65,000 ...
(Date:6/20/2017)... , ... June 20, 2017 , ... Kenneth Mayer, MD, ... Society (JIAS). , Dr. Mayer, who joined the JIAS Editorial Board in 2016, ... founding Medical Research Director of Fenway Health and Co-Chair of The Fenway ...
(Date:6/20/2017)... ... June 20, 2017 , ... HOUSTON – Brazos Towers at Bayou ... host of new options for today’s modern senior. Brazos Towers at Bayou Manor has ... they love while offering them the services to support that lifestyle both now and ...
(Date:6/20/2017)... SAN DIEGO, California (PRWEB) , ... June 20, ... ... modern product documentation and help content solutions for the enterprise, is proud to ... web properties, including CRM, e-commerce, ticketing systems, company websites, and more to provide ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... Calif. , June 14, 2017 The ... the City of Fremont and ... of the bio-pharma industry in California ... technology, enabling executive networking, and fostering workforce development. The ... development and growth of start-ups, as well as small ...
(Date:6/12/2017)... , June 12, 2017 Kineta, Inc., a ... announced Kineta Vice President of R&D and Head ... the Pandemic Preparedness for the Northwest and Beyond ... held on June 14, 2017 from 8:30-10:30 AM PDT at ... Dr. Bedard will be joined by ...
(Date:6/9/2017)... AirXpanders, Inc. (ASX: AXP) (AirXpanders or Company), ... sale and distribution of the AeroForm® Tissue Expander System, ... commercial roll-out in the United States ... hundred (100) medical institutions and health systems, located throughout ... alternative for women who choose reconstructive surgery following a ...
Breaking Medicine Technology: