Navigation Links
The future of stem cell applications challenging, bright
Date:6/8/2011

An article in the current issue of Technology & Innovation, Proceedings of the National Academy of Inventors reports on the bright future and enormous need for stem cell therapeutics that may offer hope for those suffering from debilitating and deadly diseases.

http://www.ingentaconnect.com/content/cog/ti/2011/00000013/00000001

Stem cell transplantation may offer therapy through "simple cell replacement" procedures to restructure damaged organs, tissues and cells, or provide methods for "reawakening" biological cues to regenerate cells.

"The future for stem cell applications is indeed promising, although there are no assurances that cures will be found," said corresponding author Dr. John Sladek, a professor of the University of Colorado College of Medicine's Departments of Neurology and Pediatrics. "However, there is scientific consensus that time and innovation, combined with a dose of serendipity, will lead to the cures people deserve."

According to Dr. Sladek and co-author Dr. Kimberly Bjugstad, also from the UC Department of Pediatrics, the need for stem cell therapies (based on two categories of stem cells, embryonic stem cells (ESCs), able to differentiate into many kinds of cells (pluripotent), and adult (somatic) stem cells, less capable of high differentiation) - corresponds to many of the diseases most responsible for mortality. The list of potential stem cell therapy targets includes: cardiovascular diseases, cancer, neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, spinal cord injury and autoimmune diseases, including diabetes.

"One of the key, and as yet unanswered questions in cell-based therapeutics, is when in the course of human illness to intervene," said Dr. Sladek. "Traditional wisdom suggests that sooner is better."

Based on their research, Dr. Sladek and his fellow researchers suggest that younger patients with the shortest Parkinson's disease duration, for example, are more suitable for cell transplantations than patients who have suffered with the disease for a decade or longer. The less damaged brain, he said, is more receptive to new cells that function to protect and preserve remaining neurons.

Progress is great, yet scientific challenges to creating new cell-based therapies must be overcome one-by-one.

"Much more is to be learned about reprogramming cells," pointed out Dr. Sladek. "For example, induced pluripotent stem cells (iPSC) are a third source of stem cells. These cells can be reprogrammed in the laboratory to be self-renewing and pluripotent, but in some cases resist reprogramming or retain a genetic memory that may be a complication."

Besides scientific challenges, political challenges to stem cell transplantation persist as well. Despite on-and-off-again bans on federal funding for embryonic stem cell research in the U.S., to the discovery of increasingly more utility in the use of adult stem cells derived from bone marrow, fat cells and liver cells, research in the U.S. is moving forward at great speed as more animal model-based research is leading to human clinical trials.

"It is unlikely that all patients will benefit from cell-based therapies," concluded Dr. Sladek. "Factors related to patient selection need careful consideration, especially concerning stage and severity of disease, the patient's prior therapies, and the need for immunosuppression as well as many other factors."


'/>"/>

Contact: Randolph Fillmore
rfillmore@nasw.org
University of South Florida (USF Health)
Source:Eurekalert

Related medicine news :

1. The future of wireless body area networks is the focus of a June 19-20 workshop at WPI
2. High-fat diet during pregnancy programs child for future diabetes
3. Childhood cancer survivors at higher risk for future GI complications
4. When rising PSA means prostate cancer is in patients future
5. Keck Futures Initiative awards $1 million for 13 research projects
6. Immediate treatment can alleviate future back problems
7. Training future doctors to enlist patients as partners in care
8. Lifesaving antibiotics face doubtful future
9. Starting periods before the age of 10 increases risk of lung complaints in future
10. Depressing future for men?
11. Surgeons predict the future of nanomedicine in practice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... ... For breast cancer clinicians and researchers who were unable to attend the ... review and analysis of its highlights, a novel half-day, complimentary meeting—the 14th Annual Best ... February 4, 2017 in Chicago. Chaired by Kathy S. Albain, MD, FACP, FASCO from ...
(Date:1/17/2017)... ... 2017 , ... SunView Software’s Service Smart Technology has been selected as a ... , Each year, Pink Elephant recognizes a new product or service developed by an ... problem or opportunity. The award highlights original innovations that were released in 2016, either ...
(Date:1/17/2017)... Chapel, Florida (PRWEB) , ... January 17, 2017 ... ... Connected City, a new 21st century approach to infusing high speed technology into ... an area exclusively dedicated to the advancement of healthcare and wellness in a ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... online continuing education for EMS and firefighting professionals, has released four new continuing ... These new courses are taught live in an online classroom and meet the ...
(Date:1/17/2017)... OAKLAND, CA (PRWEB) , ... January 17, 2017 , ... ... been named winners of the fourth Cradle to Cradle Product Design Challenge , ... the fourth in a series of six circular design challenges scheduled to run through ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... Ximbio, a non-profit online one-stop-shop for the global ... first North American headquarters in Kendall Square, Cambridge, ... ... launch in October 2014 as a business unit of UK- ... the foundation Cancer Research UK. Ximbio.com allows scientists ...
(Date:1/18/2017)... After the recent election cycle, it ... cannabis both for medical and recreational purposes are shifting. The ... the use of cannabis, but the focus is coming from ... Research, the North American legal cannabis market posted $6.7 billion ... The research projects sales will grow at a compound annual ...
(Date:1/18/2017)...  Astellas Pharma Inc. (President and CEO: ... participation in Access Accelerated, a global, multi-stakeholder initiative ... diagnostics and treatment in low-income and lower-middle income ... and in collaboration with the World Bank Group ... Astellas will work towards the United Nations Sustainable ...
Breaking Medicine Technology: