Navigation Links
The first animal model for sexual transmission of HIV
Date:8/14/2013

Infection by human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), a debilitating disorder in which progressive weakening of the immune system makes affected individuals more susceptible to potentially life-threatening infections and chronic diseases. Despite advances in the treatment and management of AIDS, there is no cure, and HIV infection remains a major global health problem. According to the WHO, there were an estimated 34 million infected individuals in 2011. Over the last three decades, a number of animal models have been developed to study aspects of HIV infection, pathogenesis and control. However, the currently available models do not recapitulate the physiological environment of the most common route of HIV transmission worldwide, vaginal intercourse. Now, Mary Jane Potash and colleagues from St. Luke's-Roosevelt Hospital Center and Columbia University Medical Center in New York, NY, have developed an approach for modelling heterosexual transmission of HIV in vivo. Their work was published recently in Disease Models & Mechanisms.

The work stems from an earlier collaboration between Potash and David J. Volsky (also from Columbia University); they established a chimeric HIV clone with a genetic modification that allows the virus to propagate in rodents instead of humans. Infection of mice with these viruses has been successfully applied to study aspects of HIV neuropathogenesis and to evaluate antiretroviral drugs and potential HIV vaccines. In their latest study, Potash and colleagues describe the efficient and reproducible transmission of chimeric HIV from infected male mice to uninfected females via mating, providing the first report of HIV transmission by coitus in an animal model. Treatment of females with antiretroviral drugs prior to mating prevented transmission of the virus, in lin
'/>"/>

Contact: Paraminder Dhillon
paraminder.dhillon@biologists.com
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Precise Care is First Practice in Orange County to Offer SPG Block
2. Documentary Film Homo Intelligens - the First Generation Claims the Evolution of Humans into a New Species to be Imminent on July 28th 2014
3. Announcing the First Forward Thinking Medical Insurance Alternative By Online USA Doctors
4. 2nd Swing Golf Surpasses $50,000 in Donations to The First Tee
5. Dr. James Wire First in Minnesota to Use Natrelle 410 Gummy Bear Breast Implants
6. Homeland Grocery Stores Accepting Applications for First Ever “Get Healthy Challenge"
7. Midbrook Medical Designs First Ever Method to Help Sterile Processing Technicians Improve Efficiency in Cleaning Robotic Surgical Instrumentation
8. Vaginal Mesh Lawsuit Lawyers at Wright & Schulte LLC Report on Developments in First Federal Trial of C.R. Bard Vaginal Mesh Lawsuit
9. Women's Strike Force Announces First Fund Distribution to Virginia House of Delegates Candidates for November Race
10. Syosset, Southside Hospitals Are First on Long Island to Offer MRI-Compatible Spinal Cord Stimulator
11. Robotic Surgery Lawsuit News: Bernstein Liebhard LLP Notes Filing of First Da Vinci Lawsuit in New Jersey
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... Albany, NY (PRWEB) July 12, 2014 ... to 2020 - New and Late-Stage Four-Factor PCCs ... in-depth analysis of the critical care market in ... and Canada. The report provides an estimation of ... to 2020. It covers critical care indications that ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 As reported in ... Institute of Standards and Technology), the June 25th, 2014 Supreme ... electronic discovery world. It was also met with ... depending on whether it was seen from an individual privacy ... much is fact, there is now precedent which will require ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Dubai is ... basketball legend is heading to the UAE. The ... champion will be in the UAE from 28-31 October ... in support of diabetes awareness. The event is being ... marketing and event management company based in Dubai. The ...
(Date:7/12/2014)... 12, 2014 Praeclarus Press ... as a valuable new resource for women in need ... American women work away from their children. Today’s mothers ... benefits of breastfeeding, but often feel unsupported when it ... babies. With its evidence-based insights, and written by Nancy ...
(Date:7/12/2014)... July 12, 2014 Restore My Vision ... and Samantha Pearson, a couple boasting very impressive credentials ... Restore My Vision Today as a way to help ... have become in their respective patients’ treatments . ... to a “secret” trove of pertinent information relevant to ...
Breaking Medicine News(10 mins):Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 3Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 4Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 5Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3
... Antibiotic resistance is one of the biggest problems worldwide. ... be developed to fight these new antibiotic resistant infections. ... at Colney in Norfolk say they have used natural ... infections. Researchers said the discovery would allow scientists race ...
... used for treating obstructive sleep apnea patients, by making them ... resolving heart abnormalities, says Belgium physicians. // ,OSA ... ,"Not only are the shape and size ... was dilated and the heart muscle on the left side ...
... has been long regarded to be a chronic and unremitting ... temporary or short-lived condition // from which affected individuals can ... the same thing about alcohol. But now I think that ... what compulsive gambling is - for some people it is ...
... the NHS Heath Scotland, has had its lines choked with ... in Scotland since Sunday, last. // The line which ... fold increase of almost 450 calls a day, post ban ... flow of calls. This is a shot in the arm ...
... of the European Commission would be targeted towards controlling ... and malaria // that are haunting the Asian region. ... and TB through External Action' would be launched neat ... aimed at reducing the financial constraints that prevent the ...
... syndrome (PTSD) is a disabiling anxiety disorder, which was ... World War I, as soldier's heart and shell shock ... who are affected by cancer and their families as ... PTSD affects about 10 percent of those exposed to ...
Cached Medicine News:Health News:Compulsive Gambling Not A Chronic Addiction Always: Research 2Health News:Control And Prevention Of Three Diseases To Be Discussed: European Commission 2Health News:New Therapy For Treating Post-Traumatic Stress Syndrome 2
(Date:7/10/2014)... 2014   Ventana Medical Systems, Inc.  (Ventana), a ... entered into an agreement with Merck KGaA, Darmstadt, ... in the United States and ... KGaA,s biopharmaceutical division on the development and commercialization of ... Ventana,s proprietary diagnostic assays. In alignment with Merck KGaA,s ...
(Date:1/15/2014)... Sono-Tek Corporation (OTC BB: SOTK) today announced sales of  ... to sales of $2,202,000 for the prior year period, an ... also shown growth over the preceding quarter,s sales, continuing a ... year. Markets that experienced sales increases over the prior year ...
(Date:1/15/2014)... Foundation today announced it has established a relief fund ... weather that has gripped much of the nation. AARP and ... to support these emergency relief efforts AARP and AARP Foundation ... up to $500,000 in aid. The matching program will be ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... to over 2,000 medical clinics nation wide, ... in mind, ChartingPlus relies heavily on a ... to improve documentation quality and increase productivity ... medical content is specific to your medical ...
... EncounterPRO Electronic Health Record ... System (WfMS) Specialties that ... and Immunology, Cardiology, Dermatology, ... Medicine, Neurology, Neurosurgery, Obstetrics ...
MediNotes e is an EMR design which utilizes a "tab concept for navigation. MediNotes e can display multiple patients, encounter notes, workflow items, patient flow, messages, alerts, and more, all in...
... Medical Record Software Interface ... Interface with programs, populates ... custom reports. Accumedics Electronic ... is Microsoft compatible allowing ...
Medicine Products: