Navigation Links
The factor that could influence future breast cancer treatment
Date:12/27/2012

Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. The research, which has significant implications for breast cancer treatment, is published December 27 in the open access journal PLOS Biology.

Transcription factors are molecules that switch genes on or off. In this case, the transcription factor known as 'ELF5' inhibits sensitivity to estrogen very early in the life of a breast cancer cell. In 2008, Professor Chris Ormandy from the Garvan Institute of Medical Research in Sydney, Australia, showed that ELF5 was responsible for the development of breast progenitor cells into the estrogen-receptor-negative cells that produce milk in the breast during pregnancy.

In the current study, a team led by Ormandy in collaboration with Drs Maria Kalyga and David Gallego-Ortega, has shown that the same molecular decision occurs in breast cancer and that ELF5 has the ability to change an existing tumour into an estrogen-insensitive tumour.

"This work tells us that cancers which become refractory to anti-estrogen treatment often do so by elevating their levels of ELF5 and becoming functionally estrogen receptor negative," said Ormandy.

The team has also described the genetic mechanisms by which ELF5 opposes the action of estrogen, and has shown that it is possible to alter the subtype of breast cancer by manipulating ELF5 levels in cancer cells in the laboratory.

"This raises the therapeutic option of manipulating ELF5 levels to treat breast cancer. As ELF5 is intracellular, this could possibly be done with small molecule therapies that penetrate cells and target protein-to-protein interactions, or with small inhibitory RNAs. There is also the possibility of testing ELF5 levels in tumours to predict response to treatment and therefore guide treatme
'/>"/>

Contact: Bryan Ghosh
bghosh@plos.org
44-122-344-2837
Public Library of Science
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The factor that could determine future breast cancer treatment
2. Tips For Weight Loss from Health Reviews - How the “Fat Loss Factor” Helps People Lose Weight Successfully
3. Parents addiction, unemployment and divorce are risk factors for childhood abuse
4. Stemedica and Scripps to Jointly Investigate Therapeutic Effect of Ischemia Tolerant Mesenchymal Stem Cells (itMSC) and Stem Cell Factors in Lung Injury and Sepsis
5. Cultural, social factors identified as barriers to minority participation in stem cell donation
6. Why are kids in asthma hotspots in NYC more likely to visit the ER? Exercise may be a factor
7. Study shows COPD is not independent risk factor for lung cancer
8. Moffitt researchers say effective immunotherapy for melanoma hinges on blocking suppressive factors
9. Fat Loss Factor Program Review of Dr Charles Livingston's Weight Loss Plan Revealed
10. Depression a Key Factor in Health of Parkinsons Patients: Study
11. The Journal of Nursing Research receives impact factor ranking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... After Susan Wakulich was told she had an aneurysm, she ... of her. , "I was devastated," said Wakulich, who is ... knew this was a serious diagnosis. Then I met Dr. ... involved a less invasive procedure. It was something I didn,t ... in a multi-center U.S. clinical trial to evaluate the safety ...
(Date:7/9/2014)... findings from Fox Chase Cancer Center paint a relatively ... of breast cancers that have spread to the chest ... that grow into the skin, regardless of size and ... as stage III and called "locally advanced" tumors, ... cancer, often with poor survival. Locally advanced breast cancers ...
(Date:7/9/2014)... This news release is available in French . ... different factors in 14 year old teens, including brain structure ... with 70% accuracy who will go on to develop binge ... lack of conscientiousness, and other variables such as life events ... likelihood of binge drinking. Whether or not the child ...
(Date:7/9/2014)... reputation for being highly toxic, but when used in the ... to offer potential health benefits in a range of issues, ... compound (AP39), designed and made at the University of Exeter, ... of very small amounts of the substance to the right ... have already found that the compound protects mitochondria the ...
(Date:7/9/2014)... PHILADELPHIA Previous studies linking older age with kidney ... of living kidney donation among older adults. However, in ... researchers at the Perelman School of Medicine at the ... years and above) enjoy similar life expectancy and cardiovascular ... donate their kidneys. In light of the ever increasing ...
Breaking Medicine News(10 mins):Health News:New type of stent could help some brain aneurysm patients 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:What drives a child to abuse alcohol? 2Health News:Rotten egg gas holds key to healthcare therapies 2Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2
... Device can provide solution for early detection of ear ... Parents are blogging and tweeting away this winter on ... 1 reason for children,s visits to the emergency room."Parents ... illnesses, especially ear infections," says Joe Kessinger of Innovia ...
... Analyst Briefing on Thursday, 26 February 2009 LONDON, ... Frost & Sullivan is pleased to announce ... Trends Impacting the Chemicals and Materials Market to ... 3 p.m. GMT.(Logo: http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO )Medical applications ...
... WEST BABYLON, N.Y., Feb. 17 New paintbrush ... by the ArroWorthy Co. NY, is designed to ... ergonomically contoured handle allows a variety of gripping ... hook is incorporated for on job resting or ...
... for global health also launched at GSM conference , ... ... -- Three of the world,s leading foundations involved in global ... Foundation and The Vodafone Foundation--announced today at GSMA,s Mobile World ...
... Arkansas-based electronic medical transcription and document management software provider, will ... , ... Little Rock, AR (PRWeb) ... document management software provider eMedDox (formerly Health Data Services, LLC) ...
... of blood sugar and its possible role in preventing cardiovascular disease is ... , ... Somerville, NJ (PRWEB) February 17, 2009 -- Does the control ... 2 diabetes, contribute to the prevention of cardiovascular disease? While earlier ...
Cached Medicine News:Health News:Video: Ear Infections Spark Online Conversations Among Concerned Parents 2Health News:Frost & Sullivan Helps You Know Your End-Market: Medical Trends Impacting the Chemicals and Materials Markets 2Health News:Frost & Sullivan Helps You Know Your End-Market: Medical Trends Impacting the Chemicals and Materials Markets 3Health News:Efficient and Comfortable, the Right Brush(R) is the First Revolution in Painting Since the Roller 2Health News:Efficient and Comfortable, the Right Brush(R) is the First Revolution in Painting Since the Roller 3Health News:Leading Foundations to Form mHealth Alliance 2Health News:Leading Foundations to Form mHealth Alliance 3Health News:Leading Foundations to Form mHealth Alliance 4Health News:New Website Coming Soon for Electronic Medical Transcription Company 2Health News:Cardiovascular Disease and Diabetes: New Blog and Slide Presentation on the Diabetes Best Practices Website Discuss the Most Recent Studies in this Field 2Health News:Cardiovascular Disease and Diabetes: New Blog and Slide Presentation on the Diabetes Best Practices Website Discuss the Most Recent Studies in this Field 3
(Date:1/14/2014)... 14, 2014 InformEx, North America,s ... chemistry, will hold the 30 th edition of its ... Convention Center from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ... pharmaceutical, fine chemical and specialty chemical companies will take part ...
(Date:1/14/2014)... , Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s new ... targeting guide with accompanying instrumentation to place and insert ... to the soft tissue (e.g. ligament) repair or reconstruction ... repair heals. (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ...
(Date:1/14/2014)... 2014 NineSigma , Inc., the leading innovation ... Leadership Summit , May 14-16, 2014 at the Global ... . This is the premier ... breakthrough achievements through open innovation. Participants will learn how ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... NANJING, China, Jan. 13, 2011 /PRNewswire-Asia/ -- Simcere ... SCR ), a leading pharmaceutical company specializing ... and proprietary pharmaceuticals in China, today announced the ... for personal reasons, effective January 15, 2011. Simcere,s ...
... the third largest medical transcription service, speech recognition technology and ... has received the Best in KLAS Award for Transcription ... KLAS Awards: Software & Professional Services report. In addition ... was also rated No. 1 in their category for professional ...
Cached Medicine Technology:Simcere Pharmaceutical Group Announces Resignation of CFO Frank Zhao 2Webmedx Named Best in KLAS and Ranked #1 Transcription Services Vendor for Second Year in a Row 2Webmedx Named Best in KLAS and Ranked #1 Transcription Services Vendor for Second Year in a Row 3
... ExTOL systems feature your choice of ... electrocardiographs, an easy-to-operate monitor and the ... exercise stress testing systems also feature ... point, pre-programmed or custom protocols, and ...
... w/ Remote/Controller. Includes Full Range ... Children. Multiple 20/20 slides. Polarized ... allows you to customize your slide choices. ... with Long Life. Variety of mounting options. ...
... Ultimate in Stability. ... stabilizer features superior arm ... in the clamp/turret mechanism. ... features the ultimate flexibility ...
... leader in beating heart bypass, comes the ... NS device is the first leap in ... of surgical revascularization.,The Starfish NS Heart Positioner ... Small Thoracotomy (MVST) procedure without CPB and ...
Medicine Products: