Navigation Links
The factor that could influence future breast cancer treatment
Date:12/27/2012

Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. The research, which has significant implications for breast cancer treatment, is published December 27 in the open access journal PLOS Biology.

Transcription factors are molecules that switch genes on or off. In this case, the transcription factor known as 'ELF5' inhibits sensitivity to estrogen very early in the life of a breast cancer cell. In 2008, Professor Chris Ormandy from the Garvan Institute of Medical Research in Sydney, Australia, showed that ELF5 was responsible for the development of breast progenitor cells into the estrogen-receptor-negative cells that produce milk in the breast during pregnancy.

In the current study, a team led by Ormandy in collaboration with Drs Maria Kalyga and David Gallego-Ortega, has shown that the same molecular decision occurs in breast cancer and that ELF5 has the ability to change an existing tumour into an estrogen-insensitive tumour.

"This work tells us that cancers which become refractory to anti-estrogen treatment often do so by elevating their levels of ELF5 and becoming functionally estrogen receptor negative," said Ormandy.

The team has also described the genetic mechanisms by which ELF5 opposes the action of estrogen, and has shown that it is possible to alter the subtype of breast cancer by manipulating ELF5 levels in cancer cells in the laboratory.

"This raises the therapeutic option of manipulating ELF5 levels to treat breast cancer. As ELF5 is intracellular, this could possibly be done with small molecule therapies that penetrate cells and target protein-to-protein interactions, or with small inhibitory RNAs. There is also the possibility of testing ELF5 levels in tumours to predict response to treatment and therefore guide treatme
'/>"/>

Contact: Bryan Ghosh
bghosh@plos.org
44-122-344-2837
Public Library of Science
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The factor that could determine future breast cancer treatment
2. Tips For Weight Loss from Health Reviews - How the “Fat Loss Factor” Helps People Lose Weight Successfully
3. Parents addiction, unemployment and divorce are risk factors for childhood abuse
4. Stemedica and Scripps to Jointly Investigate Therapeutic Effect of Ischemia Tolerant Mesenchymal Stem Cells (itMSC) and Stem Cell Factors in Lung Injury and Sepsis
5. Cultural, social factors identified as barriers to minority participation in stem cell donation
6. Why are kids in asthma hotspots in NYC more likely to visit the ER? Exercise may be a factor
7. Study shows COPD is not independent risk factor for lung cancer
8. Moffitt researchers say effective immunotherapy for melanoma hinges on blocking suppressive factors
9. Fat Loss Factor Program Review of Dr Charles Livingston's Weight Loss Plan Revealed
10. Depression a Key Factor in Health of Parkinsons Patients: Study
11. The Journal of Nursing Research receives impact factor ranking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Leading eco-friendly beauty brand , Lotus ... new vegan and gluten-free Sugar Cane Fruit Mask. Their ... results skincare testers were looking for. , “My ... mask that provided results, and I think I accomplished ... Fruit Mask combines Willow bark (Salix Alba extract), a ...
(Date:9/17/2014)... (HealthDay News) -- Scientists have developed a blood-cleansing device, ... the way the blood infection sepsis is treated. ... said their device works outside the body like a ... toxins out of patients, blood. "Even with the ... care units at least 30 percent of the time," ...
(Date:9/17/2014)... to reduce the need for invasive biopsies in patients ... , In a new study, researchers developed a math ... kidney inflammation to interstitial fibrosis, scarring in the ... is the only existing way to reach a definitive ... model could also be used to monitor the effectiveness ...
(Date:9/17/2014)... 17, 2014 CarePoint Health became the ... 150 CarePoint Health employees participated in the Ice Bucket ... Association. The event took place on September 9, ... CarePoint Health donated $100 to the ALS Association for ... total of approximately $15,000. The Ice Bucket Challenge was ...
(Date:9/17/2014)... HealthDay Reporter WEDNESDAY, Sept. 17, 2014 ... made good on their pledge to cut calories in their ... together through the Healthy Weight Commitment Foundation, pledged to remove ... and 1.5 trillion by 2015. They,ve actually reduced far more: ... pledge and exceeded their pledge," said lead researcher Shu Wen ...
Breaking Medicine News(10 mins):Health News:EcoBeauty Brand Lotus Moon Unveils New Gluten-Free Sugar Cane Fruit Mask 2Health News:'Biospleen' Suggests New Way to Treat Blood Infection 2Health News:Math model designed to replace invasive kidney biopsy for lupus patients 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 3Health News:Major U.S. Food Makers Cut 6.4 Trillion Calories From Products: Report 2Health News:Major U.S. Food Makers Cut 6.4 Trillion Calories From Products: Report 3
... Minimal or Free and Best Option for Prevention;,Yet 5% Would ... Staying,Healthy., YONKERS, N.Y., Nov. 11 According to a ... to get the,flu vaccine this year, despite its being the ... long list of poor excuses,for not getting the vaccine, including ...
... First Large Scale Study Finds 73% Are From ... Consumers Union,called on hospitals today to take ... (C.-diff.) infections in light of a new report,showing ... estimates had,indicated. As the rate of hospital acquired ...
... French . , Montreal, November 11, 2008 ... that,s enabled them to reproduce complex cellular environments and ... a new study published in the journal Lab on ... Hospital Research Centre, McGill University and the Montreal Neurological ...
... is playing a key role in the largest, most ... Mental Health (NIMH) of adolescents and young adults at ... study joins the resources of Emory and seven other ... precise predictors for psychosis, and a better understanding of ...
... be an independent cause of excessive daytime sleepiness ... Researchers from Sweden performed polysomnography testing on 400 ... The apnea-hypopnea index (AHI) was calculated, and women ... very often were considered habitual snorers. Habitual snoring ...
... Proton Pump Inhibitors increase risk of major cardiovascular event by more ... for patients taking Plavix(R) Study may anticipate a role for genetic testing ... ... MHS ) today presented a study at the 2008 Scientific,Sessions of the ...
Cached Medicine News:Health News:Consumer Reports Survey: Nearly Half of Adults Won't Get Flu Vaccine, Citing Poor Excuses Like 'I Don't Get Sick' 2Health News:Consumer Reports Survey: Nearly Half of Adults Won't Get Flu Vaccine, Citing Poor Excuses Like 'I Don't Get Sick' 3Health News:Consumer Reports Survey: Nearly Half of Adults Won't Get Flu Vaccine, Citing Poor Excuses Like 'I Don't Get Sick' 4Health News:New Report Shows High C-difficile Infection Rates in U.S. Hospitals 2Health News:New Report Shows High C-difficile Infection Rates in U.S. Hospitals 3Health News:New Report Shows High C-difficile Infection Rates in U.S. Hospitals 4Health News:New laser method reproduces art masterworks to protein patterns 2Health News:Pivotal Emory study focuses on teens at risk for psychosis 2Health News:Pivotal Emory study focuses on teens at risk for psychosis 3Health News:Journal CHEST: Nov. highlights 2Health News:New study: A Common Class of GI Medications Reduce Protection Against Heart Attack in Patients Taking Widely Prescribed Cardiovascular Drug 2Health News:New study: A Common Class of GI Medications Reduce Protection Against Heart Attack in Patients Taking Widely Prescribed Cardiovascular Drug 3Health News:New study: A Common Class of GI Medications Reduce Protection Against Heart Attack in Patients Taking Widely Prescribed Cardiovascular Drug 4
(Date:9/17/2014)... DALLAS , Sept. 17, 2014   OTEMR, ... 2014 Edition Complete EHR certification, which designates that the ... the Stage 1 and Stage 2 Meaningful Use measures ... and Reinvestment Act (ARRA).  ONETOUCH EMR 2.0 was certified ... an Office of the National Coordinator-Authorized Certification Body (ONC-ACB) ...
(Date:9/17/2014)... -- Bayer HealthCare will present data on hemophilia A research ... Meeting, which takes place September 18-20 in ... shared through poster presentations, showcase Bayer,s commitment to advancing ... presented in a scientific forum. "With posters ... patients, Bayer is maintaining its commitment to research in ...
(Date:9/17/2014)... 2014  Lightbeam Health Solutions announced today an ... Direct ACO) to deploy the Lightbeam population health ... care while reducing costs. Photo - ... Accountable Care Organization is the ACO operating entity ... mission is to be the premier integrated health ...
Breaking Medicine Technology:OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 2OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 3Bayer to Present Data on Hemophilia Research at NHF in Washington, D.C. 2Bayer to Present Data on Hemophilia Research at NHF in Washington, D.C. 3Bayer to Present Data on Hemophilia Research at NHF in Washington, D.C. 4Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3
... AUSTIN, Texas, March 4, 2011 Vermillion, Inc. (Nasdaq: ... Gail Page, Vermillion,s Chief Executive Officer, will be presenting at ... Ritz Carlton, Laguna Niguel in Dana Point, CA. ... 1:00 p.m. Pacific. The presentation will be web cast and ...
... Halozyme Therapeutics, Inc. (Nasdaq: HALO ), ... extracellular matrix , today announced it plans to ... March 11, 2011 before the open of the financial ... call with the investment community at 8:00 a.m. PT ...
Cached Medicine Technology:Vermillion to Present at the Roth 23rd Annual OC Growth Stock Conference March 13-16, 2011, Laguna Niguel, CA 2Vermillion to Present at the Roth 23rd Annual OC Growth Stock Conference March 13-16, 2011, Laguna Niguel, CA 3Halozyme Therapeutics to Host Fourth Quarter and 2010 Financial Results Conference Call on March 11 2
... semi-dry electrophoretic transfer cell and PowerPac ... Efficient Transfers. Minimal Buffer Requirements. ... and Reliable Transfers. Single-Step Locking ... Capacity to Transfer Multiple Gels. ...
... Transfers depurinated DNA and RNA from agarose ... as 15 minutes ,Increases speed and efficiency ... be applied to gel ,Part of an ... and UV crosslinking in 2.5 hours, versus ...
PosiBlot 30-30 Sponges...
PosiBlot 30-30 Pads...
Medicine Products: