Navigation Links
The factor that could determine future breast cancer treatment
Date:12/27/2012

Australian scientists have shown how a 'transcription factor' causes breast cancer to develop an aggressive subtype that lacks sensitivity to oestrogen and does not respond to anti-oestrogen therapies such as Tamoxifen and aromatase inhibitors.

Transcription factors are molecules that switch genes on or off. In this case, the transcription factor known as 'ELF5' inhibits sensitivity to oestrogen very early in the life of a breast cancer cell.

In 2008, Associate Professor Chris Ormandy from Sydney's Garvan Institute of Medical Research showed that ELF5 was responsible for the development of the oestrogen-receptor-negative cells in the breast during pregnancy that produce milk.

In the current study Ormandy, in collaboration with Drs Maria Kalyga and David Gallego-Ortega, has shown that the same molecular decision occurs in breast cancer and that ELF5 has the ability to change an existing tumour to an oestrogen-insensitive type.

The team has also described the genetic mechanisms by which ELF5 opposes the action of oestrogen, and has shown that it is possible to alter the subtype of breast cancer by manipulating ELF5 levels. The findings are published in the highly prestigious journal PLoS Biology, now online.

"This work tells us that cancers which become refractory to anti-oestrogen treatment often do so by elevating their levels of ELF5 and becoming functionally oestrogen receptor negative," said Ormandy.

"This raises the therapeutic option of manipulating ELF5 levels to treat breast cancer."

"As ELF5 is intracellular, this could possibly be done with small molecule therapies that target protein-to-protein interactions, or with small inhibitory RNAs."

"There is also the possibility of testing ELF5 levels in tumours to predict response to treatment and therefore guide treatment decisions."

"Our key discovery here is that by simply manipulating one transcription factor we can change the subtype of breast cancer."


'/>"/>
Contact: Iris Hui
iris.hui@researchaustralia.org
61-292-958-545
Research Australia
Source:Eurekalert

Related medicine news :

1. Tips For Weight Loss from Health Reviews - How the “Fat Loss Factor” Helps People Lose Weight Successfully
2. Parents addiction, unemployment and divorce are risk factors for childhood abuse
3. Stemedica and Scripps to Jointly Investigate Therapeutic Effect of Ischemia Tolerant Mesenchymal Stem Cells (itMSC) and Stem Cell Factors in Lung Injury and Sepsis
4. Cultural, social factors identified as barriers to minority participation in stem cell donation
5. Why are kids in asthma hotspots in NYC more likely to visit the ER? Exercise may be a factor
6. Study shows COPD is not independent risk factor for lung cancer
7. Moffitt researchers say effective immunotherapy for melanoma hinges on blocking suppressive factors
8. Fat Loss Factor Program Review of Dr Charles Livingston's Weight Loss Plan Revealed
9. Depression a Key Factor in Health of Parkinsons Patients: Study
10. The Journal of Nursing Research receives impact factor ranking
11. Frequency of alcohol consumption and cardiovascular risk factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... Laser Skin & Wellness Center ... hands of time of female aging. The Juliet™ procedure helps to ... such as leakage, laxity, itchiness and pain have reported real relief from these and ...
(Date:5/25/2016)... NJ (PRWEB) , ... May 25, 2016 , ... Researchers ... 2016 Annual COVD Meeting for their work on visual evoked potential and human attention. ... recent studies that used the Diopsys® NOVA™ ERG and VEP Vision Testing System ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... builder, has announced that it will join America's leading engineers at the American ... held at the Georgia World Congress Center. , Engineers, speakers and exhibitors ...
(Date:5/24/2016)... ... May 24, 2016 , ... According to an article published ... randomly assigned to reduce the amount of calories they consumed by 25% experienced some ... weight enjoyed better sleep, improved quality of life, and enhanced sexual function compared to ...
(Date:5/24/2016)... ... 2016 , ... PhishLine, the best-in-class, enterprise level security solutions ... President of Sales. Cifolelli’s primary responsibilities include management of the company’s sales ... field of organizational social engineering. , “We are delighted to have Rudy ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LONDON , May 24, 2016 ... erfüllt beide primären Endpunkte ... und Überlegenheit in ‚ausgezeichneter plus guter ... aufsteigenden Colons    ,      (Logo: ... B.V. gab heute neue positive Daten von der ...
(Date:5/24/2016)... May 24, 2016 ARANZ Medical ... the healthcare sector, has been named the Coretex Hi-Tech Emerging ... 2016. Dr Bruce Davey , CEO of ... team.  It,s really good to be recognised for the work ... products are used in 35 countries around the world from ...
(Date:5/24/2016)... 2016  Joe Marziani has joined VMS BioMarketing as senior vice president of sales, ... his new role, Marziani will lead the company,s business development and sales team, exploring ... Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: