Navigation Links
The 'entrance exam' that is key to a successful pregnancy
Date:2/6/2014

Researchers have discovered how an 'entrance exam' set by the womb determines if the implantation of an embryo is successful; potentially a milestone for advances in pregnancy treatments.

The new study, led by Warwick Medical School and University Hospitals Coventry and Warwickshire NHS Trust, sheds light on how the lining of the womb analyses individual embryos and thus decides whether or not to support further development.

Before implantation, human embryos are genetically very diverse. Some embryos will contain no normal cells at all while others contain a mixture of normal and abnormal cells. Hence, no two human embryos are the same at this early stage of development.

The article, published today in Scientific Reports, shows that high quality human embryos secrete a chemical, trypsin, which renders the lining of the womb supportive of implantation. This chemical signal is deregulated in low quality embryos and causes an alarm response in the womb, which leads to either rescue or elimination of the embryo.

Professor Jan Brosens explained, "This is important, because if the lining of the womb is not well prepared for pregnancy you may find that abnormal embryos will implant or high quality embryos will not be supported. Both scenarios can lead to pregnancy loss or even late pregnancy complications, such as foetal growth restriction or preterm birth."

"Speaking in terms of an entrance exam; a poorly prepared womb will either make the test too rigorous or too lax decreasing the chances of a successful pregnancy."

Approximately 15% of clinically recognised pregnancies miscarry, attributed to the invasive nature of the human embryo and prevalence of chromosomal errors.

Professor Siobhan Quenby said, "This work adds to a growing body of evidence that assessment and optimisation of the lining of the womb may be the only effective way in preventing infertility and pregnancy complications."

The team, who were supported by researchers at the Universities of Southampton and Utrecht, believe that the news could prove vital to improving the options available to couples going through IVF, as implant failure remains the primary cause of unsuccessful treatment.

Professor Brosens added, "What we're looking at now is how to alter the lining of the womb so it can set this entrance exam at the right level and prevent implantation failure and miscarriages."


'/>"/>

Contact: Luke Harrison
luke.harrison@warwick.ac.uk
University of Warwick
Source:Eurekalert  

Related medicine news :

1. Liberty University Student Scores Among Highest in Nation on Medical School Entrance Exam
2. Researchers create database to examine vast resources of health legacy foundations
3. Study examines repeat colonoscopy in patients with polyps referred for surgery without biopsy-proven cancer
4. New study examines patterns of cancer screening in Appalachian women
5. Irresistible Desire: Review Examining Carlos Cavallo's How-To Tutorial Program Released
6. Greek God Program: Review Released Examines Greg O'Gallagher’s New Muscle Building and Nutrition Program
7. No Medical Exam Life Insurance vs Term Life Insurance: Which Is the Best Plan for Seniors
8. Senior Life Insurance Without Medical Examinations for People Who Have Heart Problems
9. Life Insurance No Medical Exam Plans Have Three Important Advantages For Seniors
10. No Medical Exam Life Insurance For People Who Underwent Liver Cancer Surgery
11. No Medical Exam Life Insurance Can Provide Coverage Before Christmas for the Whole Family
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The 'entrance exam' that is key to a successful pregnancy
(Date:2/17/2017)... ... February 17, 2017 , ... While ... Enovate Medical has introduced an innovative workstation designed to reduce nursing fatigue while ... Encore Mobile EHR Workstation offers a lightweight, highly mobile, multi-functional alternative to the ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... ... is Dr. Carol Francis' goals for each and every seminar, session ... Carol Francis will demonstrate five different brainwave tools which help energize creativity, focus ...
(Date:2/17/2017)... Austin, Tx (PRWEB) , ... February 17, 2017 ... ... of revenue cycle management services, announced today that Karen Pilley has been promoted ... expenses is critical in today’s shifting healthcare paradigm – a shift that demands ...
(Date:2/17/2017)... ... February 17, 2017 , ... Top neuroendocrine cancer doctors, nurses and specialists from ... February 21 - 23 in Beaver Creek, CO. It was announced today by Cindy ... year in Beaver Creek, hosting over 60 faculty members and addressing unmet needs of ...
(Date:2/16/2017)... ... 17, 2017 , ... Teaching nursing care of vulnerable children is the focus ... is being created with the support of the Hearst Foundations. An initiative of the ... address what has been identified as a critical gap in preparing the next generation ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... YORK , Feb. 17, 2017  BioDigital, ... today the partnership of their 3D body mapping ... healthcare IT.  The new integration will be used ... an interactive model of the human body. BioDigital ... saves clinicians time, while also increasing the precision ...
(Date:2/16/2017)... Research and Markets has announced the ... Technologies" report to their offering. ... Traditional medical devices include ... non-drug coated implantables, large endoscopes, needle based drug delivery, lab ... last two to three decades for the treatment and management ...
(Date:2/16/2017)... 2017  Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... announced that executive management will participate in the RBC ... 22-23, 2017. Adrian Adams , Chief Executive Officer, ... p.m. local time on Wednesday, February 22, 2017. ... event may be accessed from the Investors section of ...
Breaking Medicine Technology: