Navigation Links
The 'entrance exam' that is key to a successful pregnancy

Researchers have discovered how an 'entrance exam' set by the womb determines if the implantation of an embryo is successful; potentially a milestone for advances in pregnancy treatments.

The new study, led by Warwick Medical School and University Hospitals Coventry and Warwickshire NHS Trust, sheds light on how the lining of the womb analyses individual embryos and thus decides whether or not to support further development.

Before implantation, human embryos are genetically very diverse. Some embryos will contain no normal cells at all while others contain a mixture of normal and abnormal cells. Hence, no two human embryos are the same at this early stage of development.

The article, published today in Scientific Reports, shows that high quality human embryos secrete a chemical, trypsin, which renders the lining of the womb supportive of implantation. This chemical signal is deregulated in low quality embryos and causes an alarm response in the womb, which leads to either rescue or elimination of the embryo.

Professor Jan Brosens explained, "This is important, because if the lining of the womb is not well prepared for pregnancy you may find that abnormal embryos will implant or high quality embryos will not be supported. Both scenarios can lead to pregnancy loss or even late pregnancy complications, such as foetal growth restriction or preterm birth."

"Speaking in terms of an entrance exam; a poorly prepared womb will either make the test too rigorous or too lax decreasing the chances of a successful pregnancy."

Approximately 15% of clinically recognised pregnancies miscarry, attributed to the invasive nature of the human embryo and prevalence of chromosomal errors.

Professor Siobhan Quenby said, "This work adds to a growing body of evidence that assessment and optimisation of the lining of the womb may be the only effective way in preventing infertility and pregnancy complications."

The team, who were supported by researchers at the Universities of Southampton and Utrecht, believe that the news could prove vital to improving the options available to couples going through IVF, as implant failure remains the primary cause of unsuccessful treatment.

Professor Brosens added, "What we're looking at now is how to alter the lining of the womb so it can set this entrance exam at the right level and prevent implantation failure and miscarriages."


Contact: Luke Harrison
University of Warwick

Related medicine news :

1. Liberty University Student Scores Among Highest in Nation on Medical School Entrance Exam
2. Researchers create database to examine vast resources of health legacy foundations
3. Study examines repeat colonoscopy in patients with polyps referred for surgery without biopsy-proven cancer
4. New study examines patterns of cancer screening in Appalachian women
5. Irresistible Desire: Review Examining Carlos Cavallo's How-To Tutorial Program Released
6. Greek God Program: Review Released Examines Greg O'Gallagher’s New Muscle Building and Nutrition Program
7. No Medical Exam Life Insurance vs Term Life Insurance: Which Is the Best Plan for Seniors
8. Senior Life Insurance Without Medical Examinations for People Who Have Heart Problems
9. Life Insurance No Medical Exam Plans Have Three Important Advantages For Seniors
10. No Medical Exam Life Insurance For People Who Underwent Liver Cancer Surgery
11. No Medical Exam Life Insurance Can Provide Coverage Before Christmas for the Whole Family
Post Your Comments:
Related Image:
The 'entrance exam' that is key to a successful pregnancy
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a ... of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners ... October 11, 2017. , The annual award competition recognizes editorial and design excellence across ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... of $3,296 in property taxes a year. In some states—like New York, New ... , By contrast, many overseas retirement havens have extremely low property-tax rates, which ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical , ... company with their  2017 New Product Innovation Award for ... extensive primary and secondary medical device market research by Frost ... its first-to-market OTC, drug-free pain relief product, the AVACEN 100, ... to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... PARK, Calif. , Oct. 11, 2017  BioPharmX ... national scientific team that developed an innovative way to ... quantity of the delivery of new drugs. ... 2017 Fall Clinical Dermatology Conference will show how researchers ... General Hospital, Harvard Medical School used a suite of ...
(Date:10/11/2017)... 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... in Las Piedras, Puerto Rico , ... Following a ... sustained minor structural damage, temporary loss of power and ... been completed, manufacturing operations have resumed, and the company ...
Breaking Medicine Technology: