Navigation Links
The developmental genetics of space and time
Date:5/15/2013

ntal time.

Using the powerful Drosophila (fruit fly) genetic system, which includes diverse species with fully sequenced genomes, the Erives Lab identified a case of spatial and temporal conflict in the regulation of the ventral neurons defective (vnd) gene, which must be precisely regulated in order for the fly's nervous system to be properly specified. The vnd gene is induced by a concentration gradient of a key embryonic factor (dorsal/NFkB) that patterns the dorsal/ventral (D/V) axis of the embryo. In particular, the vnd gene plays a critical role in specifying distinct D/V neural columnar fates of the ectodermal compartments by encoding a repressor of additional regulators.

The role of vnd in this regulatory hierarchy requires early temporal expression, which is characteristic of low-threshold responses, but its specification of ventral neurogenic ectoderm demands a relatively high-threshold response to the morphogen.

The study shows that the vnd gene's Neurogenic Ectoderm Enhancer (NEE) takes additional input from a complementary gradient of the Dpp morphogen via a highly-conserved Schnurri/Mad/Medea silencer element (SSE), which is integral to its NEE module. In this regard, the NEE at vnd is unlike NEEs at other genetic loci, which are not involved in the neural specification circuit and have no resident SSE. They also show that an SSE could be added to a single-input NEE and cause spatial restriction of its activity. These results show how requirements for conflicting temporal and spatial responses to one morphogen gradient can be solved by additional inputs from complementary morphogen gradients.

The Erives Lab at the UI's Department of Biology studies the structure, function, and evolution of enhancers within the context of gene regulatory circuits underlying the evolution and development of animals by using molecular, genetic, and evolutionary genomic approaches. Within these areas, the Erives Lab has published
'/>"/>

Contact: Gary Galluzzo
gary-galluzzo@uiowa.edu
319-384-0009
University of Iowa
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study looks at how states decide which child receives early intervention for developmental problems
2. Pitt research sheds new light on virus associated with developmental delays and deafness
3. Flame retardants linked to neurodevelopmental delays in children
4. Improved Developmental Screening Urged for Hispanic Kids
5. Diagnosis often missed for Hispanic children with developmental delay, autism
6. Dental Woes Abound for Developmentally Disabled: Study
7. Group B streptococcal meningitis has long-term effects on childrens developmental outcomes
8. Developmental Woes Common in Siblings of Children With Autism
9. Champion of Genetics funding to Ottawa researcher
10. Ottawa researcher named 2013 Champion of Genetics
11. Johns Hopkins experts to present genetics advances at international meeting this weekend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... As the category creator and world leader ... Xoçai is to transform and improve individual ... products. One such unique element is XoVita™, a ... blueberries, an ingredient combination exclusive to Xoçai. This ... all of Xoçai products and provides a wide-ranging ...
(Date:7/25/2014)... 2014 2014 Deep Research ... Chromatography Industry” is a professional and in-depth ... Gel Permeation Chromatography market. The report provides ... Permeation Chromatography definition, classification, application, and industry ... This research covers the international market analysis, ...
(Date:7/25/2014)... 2014 American motor vehicle owners who ... can pay higher premiums for vehicle insurance on average. ... network to provide SR22 insurance for high risk motorists ... different coverage network of local agencies providing direct price ... platform now publicly available for any car owner to ...
(Date:7/25/2014)... Ticket Down announces that they ... Guinness International Champions Cup match between international soccer powerhouses ... on Sunday, July 27th. This well-known ticket ... SOCCER-2014 for added savings. , 2014 is turning out ... in North America. Countless international soccer teams have been ...
(Date:7/25/2014)... 2014 Sport Court® provided ... Nike National Invitational Tournament (NIT) in Chicago ... Junior National Tournament (USJN) in Washington D.C. at ... for these prestigious national tournaments included 44 Sport Court ... of playing surface at McCormick Place for the NIT, ...
Breaking Medicine News(10 mins):Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 2Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 3Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 4Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 2Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 3Health News:SR22 Insurance for High Risk Motorists Added to Local Quotes System at Insurer Website Online 2Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Sport Court Provides All Sports Flooring for Basketball Events in Chicago and Washington D.C. 2
... , , ... outdoor ground-level ozone, microscopic particle pollution like smoke and smog, ... is sensitive to these airborne contaminants to experience shortness of ... and cause lung irritation(1). According to AIRNow.gov(2), a government-developed index ...
... is providing valuable new clues into cancer,s deadliest behavior -- ... spreading throughout the body. Duke University biologist David ... of a single cell in the developing body of a ... one of its jobs is to connect the developing animal,s ...
... EVANSTON, Ill. --- Anyone with an MP3 device -- just about every ... a notion of the majesty of music, of the primal place it ... be seen simply as stuff of the soul -- a frill that ... Northwestern University study. The study shows that musicians -- trained ...
... , , Congressman Chaka Fattah (D-PA) releases ... healthcare system. , , WASHINGTON, Aug. 17 "We ... If real reform is to take place it must include a public option. ... in any major city they deliberate how they will get to their destination. ...
... , NEWINGTON, N.H. Aug. 17 ... atmosphere have struck a chord with consumers, is being honored in ... private companies in America. , , (Logo: ... number 471 on the lnc. 500, which ranks the nation,s top ...
... , , , , ... community, announces its donation of a fully furnished two bedroom apartment ... their families to stay for free while undergoing care at the ... and availability, the managing partners of Presidential Towers felt that this ...
Cached Medicine News:Health News:Bad Air Day Alert: Outdoor Air Pollutants at High Level 2Health News:Bad Air Day Alert: Outdoor Air Pollutants at High Level 3Health News:Cancer's break-in tools possibly identified at Duke 2Health News:Taking up music so you can hear 2Health News:Taking up music so you can hear 3Health News:Planet Fitness Soars to Inc. 500 2Health News:Presidential Towers Donates Apartment to the University of Illinois Medical Center 2
(Date:7/25/2014)... Dr. Michael Gabriel of a prominent Staten ... study, which shows how grief in pregnancy may cause obesity ... According to US News , "Unborn children ... others to grow up overweight or obese, even if that ... specific types of stress that caused obesity: "Children whose biological ...
(Date:7/24/2014)... MARSEILLE , Frankreich, July 24, ... , Weltweite Exklusivlizenz der Universität ... von Tests auf SF3B1-Mutationen, einschließlich von Next-Generation-Sequencing ... Test weist Mutationen des SF3B1-Gens nach, die ... günstigen Krankheitsverlauf vermuten lassen  QIAGEN ...
(Date:7/24/2014)... , July 24, 2014  IRIDEX Corporation (NASDAQ: ... release its second quarter 2014 financial results after the ... In conjunction with the release, the Company will host ... 5:00 p.m. Eastern Time on Thursday, July ... quarter and other business developments. Interested parties ...
Breaking Medicine Technology:Dr. Michael Gabriel of GPM Pediatrics, a Noted Staten Island Pediatrics Clinic, Comments on Study, Which Names Grief as a Cause of Obesity in Children 2QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 2QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 3QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 4QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 5
... Inc. and Cedarlane today announced that they have entered ... distribute high value reagent proteins produced by Pfenex to ... products initially distributed will be vaccine carrier proteins such ... related growth factors including G-CSF and Interferon beta 1-b. ...
... Research Group, Inc. recently published its TreatmentTrends®: Vascular ... based on online survey results from ... interventional nephrologists). It provides an in-depth view of the ... to both vascular access placement and maintenance.   ...
Cached Medicine Technology:Pfenex Inc. Establishes Reagent Protein Distribution Agreement With Cedarlane Corporation 2Latest BioTrends Report Provides Comprehensive Market Landscape of the Dialysis Vascular Access Market 2
PDA format of the well-known standard antimicrobial reference....
PDA application providing a complete guide for the diagnosis and management of electrolyte disorders....
Contains the most common procedures from all orthopedic sub-specialties organized by body area....
Consists of the print and PDA versions of Harrison's Manual of Medicine 15th Edition. Provides high-end medical content via PDA....
Medicine Products: