Navigation Links
The developmental genetics of space and time
Date:5/15/2013

Albert Erives, associate professor in the University of Iowa Department of Biology, and his graduate student, Justin Crocker, currently a postdoctoral researcher at the Howard Hughes Medical Institute (HHMI) Janelia Farm Research Campus, have conducted a study that reveals important and useful insights into how and why developmental genes often take inputs from two independent "morphogen concentration gradients."

The study appears in the Genomes & Developmental Control section of the online June 1 issue of the journal Developmental Biology. The complete paper can be found at: http://www.sciencedirect.com/science/article/pii/S0012160613001310.

Understanding the concept of morphogen gradientsthe mechanism by which a signal from one part of a developing embryo can influence the location and other variables of surrounding cellsis important to developmental biology, gene regulation, evolution, and human health.

Morphogen gradients subdivide a field of cells into territories characterized by distinct cell fate potentials and allow cells to "know" their position within a developing embryonic tissue and to differentiate appropriately. In order to function, such systems require a genetic mechanism to encode a spectrum of responses at different target genes.

This genetic mechanism takes the form of transcriptional enhancers, which are DNA sequences that display a cryptic code of transcription factor (TF) binding sites. During development and/or environmental perturbation, these enhancers serve as assembly scaffolds for TF protein complexes that orchestrate differential gene expression.

However, enhancers targeted by morphogen signaling may drive temporally inappropriate expression because morphogen gradients also provide temporal cues. That is, the morphogenic gradient builds up and decays over a specific window of developme
'/>"/>

Contact: Gary Galluzzo
gary-galluzzo@uiowa.edu
319-384-0009
University of Iowa
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study looks at how states decide which child receives early intervention for developmental problems
2. Pitt research sheds new light on virus associated with developmental delays and deafness
3. Flame retardants linked to neurodevelopmental delays in children
4. Improved Developmental Screening Urged for Hispanic Kids
5. Diagnosis often missed for Hispanic children with developmental delay, autism
6. Dental Woes Abound for Developmentally Disabled: Study
7. Group B streptococcal meningitis has long-term effects on childrens developmental outcomes
8. Developmental Woes Common in Siblings of Children With Autism
9. Champion of Genetics funding to Ottawa researcher
10. Ottawa researcher named 2013 Champion of Genetics
11. Johns Hopkins experts to present genetics advances at international meeting this weekend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... The Lymphoma Research Foundation (LRF) – ... innovative lymphoma research and serving the lymphoma community through ... patient services – is set to host its annual ... West Orange, NJ on June 1, 2015. Since 2010, ... programs through LRF. , This year, the Lymphoma Research ...
(Date:5/4/2015)... METTLER TOLEDO has announced an upcoming ... in a GXP Regulated Laboratory ", featuring independent ... will be presented on May 27, 2015 at ... a critical component of pharmaceutical product quality and ... recent years an increasing number of inspections have ...
(Date:5/4/2015)... OK and Seattle, WA (PRWEB) May 04, 2015 ... the formation of a collaboration to facilitate development of ... of ophthalmic disorders that lead to blindness, including Diabetic ... the MiDROPS™ formulation platform developed by EyeCRO, which can ... eye via a topical eyedrop. , Under the ...
(Date:5/4/2015)... 04, 2015 CCL, a top-ranked, global ... unique program to other leadership development consultancies. “The ... CCL and successful practitioners, expanding our capacity to drive ... said John R. Ryan, CCL President and CEO. , ... CCL Partner Network , it will schedule a one-on-one ...
(Date:5/4/2015)... New West Medicare is excited to ... to manage outpatient advanced imaging services for its members. ... its members are provided the right test at the ... with New West Medicare’s physicians and hospitals, Care to ... advanced imaging and provide an objective basis for informed ...
Breaking Medicine News(10 mins):Health News:Lymphoma Research Foundation Set to Host Annual Ace Lymphoma Luncheon at Mayfair Farms in West Orange, NJ 2Health News:METTLER TOLEDO Announces Live Webinar on the Importance of Data Integrity in a GXP Regulated Laboratory 2Health News:EyeCRO and NeuMedics Announce Collaboration to Utilize MiDROPS™ Technology for the Development of NM108 2Health News:EyeCRO and NeuMedics Announce Collaboration to Utilize MiDROPS™ Technology for the Development of NM108 3Health News:The Center for Creative Leadership Is Partnering with Lead Star to Create the CCL Partner Network 2Health News:New West Medicare Partners with Care to Care, LLC to Manage Advanced Imaging Services 2
... LOS ANGELES, March 5 With the nation focused ... Valley) recently announced Assembly Bill 562 ( ... to businesses and consumers that have fallen victim to ... decreases health care premium costs. It requires insurance companies ...
... YORK, March 5 An article published in the ... , a joint publication of United Spinal Association ( ... Multiple Sclerosis (NARCOMS), reveals the importance of understanding ... it can also lead to a greater understanding and ...
... day for six months were able to increase the flaccid ... erectile function by up to 36%, according to an independent ... International . , Researchers from San Giovanni Battista Hospital at ... treatment could provide a viable alternative to surgery, as the ...
... Sick or injured African-American patients wait about an ... being transferred to an inpatient hospital bed following ... study published in the journal Academic Emergency ... the urgency to find equitable, cost-effective solutions to ...
... Already Breaking down Silos and Benefiting from Paperless ... Waters Corporation (NYSE: WAT ) ... strategic partnership to integrate laboratory software for improved ... Collaborating with existing common customers, Waters(R) and LabVantage(R) ...
... Texas and SAN FRANCISCO, March 5 Preferred ... payment and transaction-processing services for the health care ... ), the world,s largest retail payments network, today ... brand for PHT,s A-Claim(TM) medical payment solution for ...
Cached Medicine News:Health News:New Health Care Legislation Stops 'Opportunistic' Insurance Pricing 2Health News:United Spinal Association Report Reveals the Importance of Studying Multiple Sclerosis in Children: Developing New Insights into MS in Adults 2Health News:Penile extender increased flaccid length by almost a third says independent clinical study 2Health News:Racial disparities in emergency department length of stay point to added risks for minority patients 2Health News:Racial disparities in emergency department length of stay point to added risks for minority patients 3Health News:Waters and LabVantage Partnership Targets Laboratory Informatics Integration to Maximize Data Management and Quality of Work 2Health News:Waters and LabVantage Partnership Targets Laboratory Informatics Integration to Maximize Data Management and Quality of Work 3Health News:Waters and LabVantage Partnership Targets Laboratory Informatics Integration to Maximize Data Management and Quality of Work 4Health News:Preferred Health Technology and Visa Inc. Team Up on Comprehensive Point-of-Service Medical Payments Solution 2Health News:Preferred Health Technology and Visa Inc. Team Up on Comprehensive Point-of-Service Medical Payments Solution 3
(Date:5/4/2015)... , May 4, 2015 PharmaEngine, Inc. ... Pharmaceuticals, Inc. (NASDAQ: MACK ) with its ... ) jointly announced that Baxter has submitted a ... Agency (EMA) for MM-398 (irinotecan liposome injection), also ... of the pancreas who have been previously treated ...
(Date:5/4/2015)... May 4, 2015  By looking at the ... distinguish between two very different conditions that can ... Henderson , MD, PhD., a Denver ... this study can help the medical ... treatment options, for Post-Traumatic Stress Disorder (PTSD) and ...
(Date:5/4/2015)... DIEGO , May 4, 2015 ... oncology company focused on the clinical development of ... data showing mitochondria-specific effects of the Company,s investigational ... enhanced anti-tumor activity when combined with a tyrosine-kinase ... found ME-344 to be a potent inhibitor of ...
Breaking Medicine Technology:PharmaEngine Announces Filing by Baxter BioScience of Marketing Authorization Application of MM-398 (PEP02) to the European Medicines Agency for Post-Gemcitabine Metastatic Pancreatic Cancer Patients 2PharmaEngine Announces Filing by Baxter BioScience of Marketing Authorization Application of MM-398 (PEP02) to the European Medicines Agency for Post-Gemcitabine Metastatic Pancreatic Cancer Patients 3New Medical Research Shows Brain Imaging Can Now Help Doctors Differentiate Between PTSD and Traumatic Brain Injuries 2New Medical Research Shows Brain Imaging Can Now Help Doctors Differentiate Between PTSD and Traumatic Brain Injuries 3MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 2MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 3MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 4MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 5
... SAN LEANDRO, Calif., Feb. 14, 2011 Mercator MedSystems, ... treating drug-resistant hypertension, announced today that Neil P. Desai, ... Desai has an extensive background in drug-delivery and global ... Prior to the acquisition of Abraxis Bioscience, Inc. (ABI), ...
... newly approved drug dabigatran is an alternative to warfarin ... atrial fibrillation, according to updated guidelines from the American ... Rhythm Society. (Logo:   http://photos.prnewswire.com/prnh/20100222/AHSALOGO ) ... Circulation: Journal of the American Heart Association, Journal ...
Cached Medicine Technology:Mercator MedSystems Appoints Neil Desai, Ph.D., to Board of Directors 2New Anti-Clotting Drug Added to Recommendations for Treating Irregular Heartbeat 2New Anti-Clotting Drug Added to Recommendations for Treating Irregular Heartbeat 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: