Navigation Links
The connection between oxygen and diabetes
Date:6/5/2014

Researchers at the University of California, San Diego School of Medicine have, for the first time, described the sequence of early cellular responses to a high-fat diet, one that can result in obesity-induced insulin resistance and diabetes. The findings, published in the June 5 issue of Cell, also suggest potential molecular targets for preventing or reversing the process.

"We've described the etiology of obesity-related diabetes. We've pinpointed the steps, the way the whole thing happens," said Jerrold M. Olefsky, MD, associate dean for Scientific Affairs and Distinguished Professor of Medicine at UC San Diego. "The research is in mice, but the evidence suggests that the processes are comparable in humans and these findings are important to not just understanding how diabetes begins, but how better to treat and prevent it."

More than 25 million Americans have diabetes 8.3 percent of the population with another 79 million Americans estimated to be pre-diabetic, according to the American Diabetes Association. Diabetes is characterized by high blood sugar levels poorly regulated by either inadequate insulin production or because cells to not respond properly to the regulating hormone. Diabetes is the seventh leading cause of death in the United States and a major risk factor for other life-threatening conditions, including heart disease and stroke.

Past research by Olefsky and others has shown that obesity is characterized by low-grade inflammation in adipose or fat tissues and that this inflammatory state can become chronic and result in systemic insulin resistance and diabetes. In today's Cell paper, the scientists describe the earliest stages of the process, which begins even before obesity becomes manifest.

First authorYun Sok Lee, PhD, a project scientist in Olefsky's lab, and colleagues fed mice a high-fat diet. They observed that the abundant saturated fatty acids in the diet activated adenine nucleot
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Healthy Brain Connections Help Maintain Intellect in Old Age
2. 2 new studies show connection between sleepiness and pro-athlete careers
3. Continuing Education Provider HomeCEUConnection.com Announces New Speech-Language Pathology Live Webinar
4. Feces fossils lend new insights into connection between Native-Americans, diabetes
5. New method to find novel connections from gene to gene, drug to drug and between scientists
6. Brains Connections May Predict Intelligence: Study
7. Researchers explore connection between popular pain relievers, bladder cancer
8. Emotional disconnection disorder threatens marriages, researcher says
9. Continuing education provider HomeCEUConnection.com Announces Upcoming Attendance at Annual American Physical Therapy Association Combined Sections Meeting in San Diego.
10. Scientists ID New Genetic Connection for Gout
11. HomeCEUConnection.com Announces Launch of New Website
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Losing Weight Your Body’s Way , In a ... the face, it certainly can be difficult to choose the ... extra favor by doing it the healthy way? Set aside ... to your body, exercise regularly, and choose foods with the ... weight; you need to exercise more and eat less. Despite ...
(Date:10/22/2014)... October 22, 2014 Akeso Biomedical, ... for the treatment of bacterial infections, microbial biofilms, and ... joined its board of directors. , Dr. ... Systems at The Massachusetts Institute of Technology, or MIT. ... since 1968. Dr. Sinskey also holds positions as Co-Director ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. ... men may lead to increased blood pressure, according to a ... rise in blood pressure for young adult women or for ... women drank lightly or moderately, their risk of high blood ... finding parallels studies in older adult men and women," said ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 (HealthDay News) -- ... NBC News in Liberia has cleared the virus from ... Medical Center in Omaha, where he had been treated for the ... confirmed by the U.S. Centers for Disease Control and Prevention found ... NBC News reported Tuesday night. "Recovering from Ebola is ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 The ... a booth at the American Foundation for Suicide Prevention’s ... The AFSP is a not-for-profit organization that hosts hundreds ... proceeds from these events are used to help understand ... education and personal relationships as well. , The ...
Breaking Medicine News(10 mins):Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3
... are beginning to recognize that the health of people ... and the environment at large. ,Health care ... They are doing away with incinerators, procuring safer construction ... ,According to the Centers for Disease ...
... time. Beer, wine and spirits bottles will now be marked ... to conceive. The decision follows fears over unusually ... warn of subsequent risks such as fetal alcohol syndrome (FAS) ... been protests from the liquor lobby that say that the ...
... that laughter brings out the humanitarian facet and the obliging nature ... conducted by Mark van Vugt and his team from the University ... study were made to watch a hilarious or a serious video ... they were given money which they could either invest in private ...
... and public health organizations in Maine criticized the anti-fluoride campaigns ... residents not to believe the false information and alter their ... for Maine Center for Disease Control had confirmed in a ... is very effective in fighting tooth decay. ...
... has undergone liver transplant is convalescing well. This was ... Russell Britz the Head of the Transplant Unit at ... minister needed this liver transplant very urgently and that ... operation done. ,The Measure for End Stage ...
... in bad light after the death of 10 animals following the ... has sparked// a nationwide recall of pet food. Veterinary offices have ... ,Menu Foods Inc., the manufacturers of many ... 50 brands of dog food and 40 brands of cat food. ...
Cached Medicine News:Health News:Hospitals in US are Going Green 2Health News:Babies and Drinks Don’t Mi 2
(Date:10/22/2014)... Calif. , Oct. 22, 2014  AcelRx ... announced that results from the  IAP310 study have ... Medicine (RAPM), a peer-reviewed journal with broad, ... 3 trial evaluating the safety and efficacy of ... tablet system (SSTS), for the treatment of post-operative ...
(Date:10/20/2014)... 20 de octubre de 2014  PneumRx, Inc. ... de la pulmonología intervencional, anunció hoy la conclusión ... 3 meses antes de lo programado. El Estudio Clínico ... dispositivo de investigación (IDE) aprobada por la FDA ... de espiral de reducción de volumen pulmonar PneumRx ...
(Date:10/20/2014)...   BioNano Genomics announced today achievement of a ... human data at 30X depth, sufficient for a genome map, ... was established and demonstrated for the IrysChip TM V2, ... and will be rolled out to BioNano,s collaborators and ... this advancement at the American Society for Human Genetics ...
Breaking Medicine Technology:AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3BioNano Genomics Announces One Human : One Chip : One Day 2BioNano Genomics Announces One Human : One Chip : One Day 3
... Nov. 27, 2011  FUJIFILM Medical Systems U.S.A., Inc. ... latest addition to the company,s Synapse® RIS and ... North America (RSNA) 2011 Annual Meeting. Version 6.1 ... the ability to better monitor and manage performance ...
... CINCINNATI, Nov. 25, 2011 About 16 months after ... – the company that helped create and build the ... toward its new product development and growth goals. ... on breast biopsy, Mammotome is re-focused, re-energized, and re-committed," ...
Cached Medicine Technology:Latest Version of Fujifilm's Synapse® RIS and TeleRIS Now Available 2Latest Version of Fujifilm's Synapse® RIS and TeleRIS Now Available 3Mammotome Marks Key Milestones as It Grows U.S. and Global Presence 2Mammotome Marks Key Milestones as It Grows U.S. and Global Presence 3
Hydragel K20 is Sebia's quality line of manual agarose gel electrophoresis products. Samples are applied utilizing the same patented applicator combs that is used for sample application on the HYDRAS...
Handheld Digital Retinal Camera...
Inquire...
Specifically for placing follicular units....
Medicine Products: