Navigation Links
The cells' petrol pump is finally identified
Date:5/24/2012

Our cells breathe and digest, as does the organism as a whole. They indeed use oxygen to draw the energy contained in the nutrients they ingest, before discarding the waste, as carbon dioxide and water. Glucose is a preferred nutrient for the cells. Its digestion occurs in the cytoplasm, in the absence of oxygen, and leads to the formation of pyruvate and a small amount of energy. Pyruvate is then carried into mitochondria, the cell's power plants, for a complete burning, thus providing a maximal energetic yield.

A mediocre energetic yield in tumor cells

'As opposed to healthy cells, tumor cells produce the energy they need mainly in the cytoplasm. For reasons that are still misunderstood, they have little use for their mitochondria', notes Jean-Claude Martinou, professor at the University of Geneva, Switzerland. However, cancer cells don't seem to lack energy. They compensate the low energetic yield by an increased consumption of glucose. This strategy allows them to do without oxygen, to a large extent. By short-cutting the mitochondria, these cells would thus escape from the deleterious effects of toxic molecules, such as free radicals, produced during the cellular respiration, within the power plants.

How can the fuel pipeline be redirected to its normal pathway?

'Biologists have been attempting for more than thirty years to understand how pyruvate is transferred from the cytoplasm to the interior of the mitochondrion. We finally identified the carrier, which was named Mitochondrial Pyruvate Carrier, abbreviated MPC, details Sbastien Herzig, researcher at the Department of cell biology of the University of Geneva and first author of the article.

MCP is a universal carrier, which is almost identical from yeast to human. 'From now on, we will be able to study how the cells can modulate the activity of this carrier, according to their needs in energy', explains Jean-Claude Martinou. The next challenge will be to find a wa
'/>"/>

Contact: Jean-Claude Martinou
Jean-Claude.Martinou@unige.ch
0041-223-796-443
Universit de Genve
Source:Eurekalert

Page: 1 2

Related medicine news :

1. McMaster University researchers discover drug destroys human cancer stem cells but not healthy ones
2. Neuron-nourishing cells appear to retaliate in Alzheimers
3. Study: Heart damage after chemo linked to stress in cardiac cells
4. Scientists discover marker to identify, attack breast cancer stem cells
5. All cancer cells are not created equal
6. Drug kills cancer cells by restoring faulty tumor suppressor
7. Rutgers team discovers novel approach to stimulate immune cells
8. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
9. Cancer Cells in Bloodstream Show Great Diversity: Study
10. Scripps Research scientists show how memory B cells stay in class to fight different infections
11. Gut flora affects maturation of B cells in infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... August 22, 2014 Dealing with a drug ... when the addict is a child. Adolescent substance abuse has ... a long time. But a new helpline is now providing ... professional youth rehab for something like a teen drug ... designed to help make a positive impact in the community. ...
(Date:8/22/2014)... August 22, 2014 According to ... System and Adaptive Cruise Control (ACC) System Market ... Forecasts 2014 - 2019", published by MarketsandMarkets, classifies ... Market in terms of volume and value. The ... years as well as covers review of the ...
(Date:8/21/2014)... August 22, 2014 The natural loss of ... lines, wrinkles and sagging of skin. Using products to ... age 40, the body has lost about 15% of it ... 45%," says Kathy Heshelow, founder of Sublime Beauty®. "Collagen ... it - well, we know what happens." , Collagen in ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 Local agencies ... have larger discounts for specific protection plans, according to ... helping consumers to quote life insurance from local agencies ... The local agents that appear inside of the national ... fast method of price reviews this year. Adults who ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 AVEC ... to announce the addition of Kerry Gillespie as ... of healthcare management experience, Gillespie brings an extremely ... multiple executive management positions with prominent industry leading ... served as President of Triad Isotopes, Inc. a ...
Breaking Medicine News(10 mins):Health News:Cincinnati’s New Troubled Teen Helpline is Making a Difference in the Community 2Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 2Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 3Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 4Health News:4 Skincare Products That Boost and Nurture Collagen on Sale at Sublime Beauty® 2Health News:4 Skincare Products That Boost and Nurture Collagen on Sale at Sublime Beauty® 3Health News:Life Insurance from Local Agents Now Priced Nationally Through Complimentary Tool Online 2Health News:Kerry Gillespie Appointed as Chief Executive Officer of AVEC Health Solutions 2
... campuses of the University of California has found that flash-heating ... virus. ,The researchers hope that this technique - ... pan of water over a flame or single burner - ... nations will soon be able to more safely feed their ...
... rigorous U.S. trial comparing two traditional operations for stress ... urologists and urogynecologists supported by the National Institutes of ... more women achieve dryness than the Burch technique. ... a meticulous, relatively long-term comparison of these common surgeries ...
... given people another reason to quit smoking, by finding that ... depression in comparison to those who never smoke. ,The ... an elevated risk of depressive symptoms in short run, this ... long run. ,In other words, both completely ...
... Well, it doesnt have to be that way ... say that they have successfully managed to reduce ... containing vitamin A. ,Not only did the ... 23 people revealed it boosted levels of important skin ...
... a condition that most people prefer not to talk about, ... this embarrassing problem. It's called overactive bladder (OAB) and ... sometimes causing urine leakage. ,Now, to reduce the ... using nerve stimulation in the ankle to better help control ...
... chronic gum disease periodontitis, may have an increased risk of ... ,Periodontitis is an oral infection thought to be caused by ... well. ,The study was conducted by a team ... of New York at Buffalo and the Roswell Park Cancer ...
Cached Medicine News:Health News:Flash-heating Inactivates HIV in Breast Milk: Study 2Health News:Flash-heating Inactivates HIV in Breast Milk: Study 3Health News:Sling Surgery Better Than Burch for Treating Stress Incontinence in Women 2Health News:Sling Surgery Better Than Burch for Treating Stress Incontinence in Women 3Health News:Regular Smokers are at the Risk of Developing Depression 2Health News:Wrinkles can Be Really Ironed Out, Thanks to Vitamin A 2Health News:Stimulating the Ankle Can Help Patients With Overactive Bladder 2Health News:Men With Chronic Gum Disease at Higher Risk of Tongue Cancer 2
(Date:8/21/2014)...  Vermillion, Inc. (NASDAQ: VRML ), a ... health, has appointed Holly B. Bauzon as ... Ms. Bauzon has a proven track record in both ... services companies. She has more than 20 years of ... held the position of Director, Lab Services Sales and ...
(Date:8/21/2014)... Aug. 21, 2014  eRelevance Corporation ( www.erelevancecorp.com ... today that it has completed integration with Nextech, ... Plastic Surgery and Dermatology practices. "Integration ... to healthcare practices using Nextech," stated Bob ... "Using information from the EMR we are able ...
(Date:8/21/2014)... YORK , Aug. 21, 2014  Publicis Groupe ... Shannon Hartley , Managing Partner and Healthcare Industry Group ... PharmaVoice 100, which recognizes the most inspiring people in ... are leaders in research and development, marketing, technology, creativity, ... agency in 2006 as a partner in its leading ...
Breaking Medicine Technology:Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Shannon Hartley Shines in PharmaVOICE 100 2
... take the words "mobile operating table" literally! The ... important functions of a general purpose operating table ... For table operations, a cable connected hand control, ... available. Plus, there is a control panel at ...
... carbon fiber c-arm table allows 50 ... brachytherapy, gynecology, gastroenterology, cardiovascular, orthopedic, ENT, ... design allows easy access for all ... 16-inch elevating travel, 16-inch longitudinal travel, ...
... for procedures where stability, access, and ... A cantilevered low attenuation carbon fiber ... The radiolucent area is free of ... and unobstructed C-Arm positioning. Functional design ...
... Lyphochek Elevated Immunosuppressant Control is a bilevel ... blood. This unique product is ideal for ... high Cyclosporine levels, such as C2 monitoring, ... at two hours post-dose., ,Lyphochek Elevated Immunosuppressant ...
Medicine Products: