Navigation Links
The cells' petrol pump is finally identified
Date:5/24/2012

Our cells breathe and digest, as does the organism as a whole. They indeed use oxygen to draw the energy contained in the nutrients they ingest, before discarding the waste, as carbon dioxide and water. Glucose is a preferred nutrient for the cells. Its digestion occurs in the cytoplasm, in the absence of oxygen, and leads to the formation of pyruvate and a small amount of energy. Pyruvate is then carried into mitochondria, the cell's power plants, for a complete burning, thus providing a maximal energetic yield.

A mediocre energetic yield in tumor cells

'As opposed to healthy cells, tumor cells produce the energy they need mainly in the cytoplasm. For reasons that are still misunderstood, they have little use for their mitochondria', notes Jean-Claude Martinou, professor at the University of Geneva, Switzerland. However, cancer cells don't seem to lack energy. They compensate the low energetic yield by an increased consumption of glucose. This strategy allows them to do without oxygen, to a large extent. By short-cutting the mitochondria, these cells would thus escape from the deleterious effects of toxic molecules, such as free radicals, produced during the cellular respiration, within the power plants.

How can the fuel pipeline be redirected to its normal pathway?

'Biologists have been attempting for more than thirty years to understand how pyruvate is transferred from the cytoplasm to the interior of the mitochondrion. We finally identified the carrier, which was named Mitochondrial Pyruvate Carrier, abbreviated MPC, details Sbastien Herzig, researcher at the Department of cell biology of the University of Geneva and first author of the article.

MCP is a universal carrier, which is almost identical from yeast to human. 'From now on, we will be able to study how the cells can modulate the activity of this carrier, according to their needs in energy', explains Jean-Claude Martinou. The next challenge will be to find a way to force the mitochondria of tumor cells to function normally, by stimulating pyruvate transport towards the interior of these power plants.


'/>"/>
Contact: Jean-Claude Martinou
Jean-Claude.Martinou@unige.ch
0041-223-796-443
Universit de Genve
Source:Eurekalert

Related medicine news :

1. McMaster University researchers discover drug destroys human cancer stem cells but not healthy ones
2. Neuron-nourishing cells appear to retaliate in Alzheimers
3. Study: Heart damage after chemo linked to stress in cardiac cells
4. Scientists discover marker to identify, attack breast cancer stem cells
5. All cancer cells are not created equal
6. Drug kills cancer cells by restoring faulty tumor suppressor
7. Rutgers team discovers novel approach to stimulate immune cells
8. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
9. Cancer Cells in Bloodstream Show Great Diversity: Study
10. Scripps Research scientists show how memory B cells stay in class to fight different infections
11. Gut flora affects maturation of B cells in infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... LA (PRWEB) , ... October 12, 2017 , ... Planet ... in the U.S., announced today its plans to open a flagship location in Covington, ... occupy the former Rooms To Go store next to Office Depot in the Holiday ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... D.C., for the 49th Congress of the International Society of Paediatric Oncology ... the Center for Cancer and Blood Disorders at Children’s National, and Stephen ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:9/28/2017)... 28, 2017 Cohen Veterans Bioscience and Early ... of wearable and home sensors for real-time monitoring of ... Foundation, a nonprofit organization focused on disruptive health solutions ... affordable analytical system to record and integrate behavioral, cognitive, ... ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
Breaking Medicine Technology: