Navigation Links
The brain's connectome -- from branch to branch
Date:7/28/2011

er 70 students from Heidelberg University, they reconstructed a network of over 100 neurons from the retina in full detail.

The students used the KNOSSOS software developed by the team in Heidelberg to trace the connections between the neurons. It is no coincidence that the program is named after Crete's legendary palace, renowned for its elaborate labyrinth: "Tracing the connections in the brain is at least as hard as finding your way out of a mythological labyrinth", explains Moritz Helmstaedter.

In order to reconstruct a neural circuit, researchers start by staining the neurons of a section of tissue with heavy metals to make them visible. Using three-dimensional electron microscope images, they start at the cell body and follow the dendrites and axons, marking the branch point nodes on the screen. Then they use the computer to generate a three-dimensional image of the section. In this way, they work their way through the tangle of neurons bit by bit. It is a tedious undertaking: One person working alone with the currently available programs would take at least 30 years to reconstruct a path of 30 centimetres in length. Besides, these procedures are prone to error, since the branch points are not always easily recognised and the annotator's attentiveness decreases with time.

The KNOSSOS software considerably reduces the time required: It is about 50 times faster than other programs used up to now. In addition, the RESCOP program now makes it possible for dozens of people to work on the reconstruction at the same time. Since the method is easily learned, even non-experts can use it. Most of the students worked from home and sent their results to the scientists via e-mail. The scientists were able to establish that the error rate of the best students was no higher than that of experienced neurobiologists. Moreover, its sophisticated algorithms enable RESCOP to detect and average out inaccuracies. This means that the reconstruction is
'/>"/>

Contact: Dr. Moritz Helmstaedter
moritz.helmstaedter@mpimf-heidelberg.mpg.de
49-622-148-6149
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Pro Athletes Brains React at Olympic Speed
2. iPhone Memory Aid for Scatterbrains, Aging Baby Boomers and Busy, Forgetful People
3. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
4. Scientists Tweak Subjects Brains to Alter Their Moral Choices
5. SharpBrains Launches First Brain Fitness Innovation Awards to Recognize Neuroplasticity Pioneers
6. Morphine May Protect Brains of People With HIV
7. SKyPRO Releases Public Beta of GWTalk at BrainShare
8. Blood flows differently through the brains of schizophrenic patients
9. Adolescent brains biologically wired to engage in risky behavior, study finds
10. Gay mens bilateral brains better at remembering faces: York U study
11. Tool manipulation is represented similarly in the brains of the blind and the sighted
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The brain's connectome -- from branch to branch
(Date:8/21/2014)... 21, 2014 Denver marketing agency ... for the American Lung Association in Colorado’s 2014 ... welcome Webolutions as a sponsor,” said Curt Huber, Chief ... Executive Director, American Lung Association in Colorado, “and we’re ... in this role they’ve defined.” , Webolutions has also ...
(Date:8/21/2014)... August 21, 2014 If chocolate is good ... will soon be very happy and healthy. Tracie is the ... Break ” contest. She and three of her coworkers will ... luxuriate at the world-famous Chocolate Spa® at The Hotel Hershey® ... third year working in the ambulatory surgery center at Connecticut ...
(Date:8/21/2014)... Rockville Centre, NY (PRWEB) August 21, 2014 ... injury law firm with over 25 years of experience ... dangerous prescription drugs and defective medical devices, announces the ... offer information to those women who believe they have ... The site offers valuable information about the severe adverse ...
(Date:8/21/2014)... Michael E. Steuer , local doctor ... to the Bluff City with recent philanthropy at local synagogue. ... the United States,” says friend and Rabbi David Julian of ... such as providing in-house for the needy and teaching Hebrew ... in the local synagogue. And to remain close with the ...
(Date:8/21/2014)... August 21, 2014 InSilico ... interventions and addressing the challenges of a ... OncoFinder, for signalome-wide pathway analysis. This ... cross-platform analysis of gene expression data obtained ... published in the journal Frontiers in Molecular ...
Breaking Medicine News(10 mins):Health News:Denver Marketing Agency Webolutions Named Inspirational Sponsor for 2014 Run the ‘Rocks 5K 2Health News:Denver Marketing Agency Webolutions Named Inspirational Sponsor for 2014 Run the ‘Rocks 5K 3Health News:Connecticut Nurse Wins a Sweet Prize from California Casualty 2Health News:Rottenstein Law Group LLP Announces Launch of WeHelpWomen.com 2Health News:OncoFinder, a new algorithm for minimizing errors in high-throughput transcriptome analysis 2
... INDIANAPOLIS, Sept. 14 In conjunction with today,s announcement ... to patients, Eli Lilly and Company (NYSE: ... Center of Excellence and its five business units: oncology, ... These leaders will provide improved line of sight to ...
... in dementia care is not so much related to equipment ... communication problems and misunderstandings. This is shown in a new ... Sweden. Dementia not only affects the memory and other ... to walk. ,The symptoms of dementia are very individual ...
... , AHIP to leverage MedAssurant,s datasets and ... affordability of healthcare. , , WASHINGTON, ... Inc., announced today that MedAssurant, through its healthcare data analytics ... quality and effectiveness of treatments. , , ...
... boosting the odds, experts say, , MONDAY, Sept. 14 (HealthDay ... the odds that a child will develop asthma or allergies, ... spent more than 1,000 hours swimming in chlorinated pools, either ... of having asthma than did teens who primarily swam in ...
... , , NCCN is ... forum to discuss the regulatory and operational aspects of research ... improvements can be made. Scheduled for October 26 - 27 ... and panel discussions on topics that challenge the conduct of ...
... Schizophrenia is a major public health problem. Affecting almost ... economic and social toll in addition to the distress, ... disease. Elements of the disease are present from birth, ... becomes fully expressed in early adulthood with long-lasting implications ...
Cached Medicine News:Health News:Lilly Names New Business Leaders 2Health News:Lilly Names New Business Leaders 3Health News:Lilly Names New Business Leaders 4Health News:Lilly Names New Business Leaders 5Health News:Lilly Names New Business Leaders 6Health News:Lilly Names New Business Leaders 7Health News:Lilly Names New Business Leaders 8Health News:Communication problems in dementia care cause physical strain 2Health News:MedAssurant to Support AHIP's Research Capabilities 2Health News:Chlorine in Pools Raises Kids' Asthma, Allergy Risk 2Health News:Chlorine in Pools Raises Kids' Asthma, Allergy Risk 3Health News:NCCN Holds Oncology Research Best Practices Conference 2Health News:NCCN Holds Oncology Research Best Practices Conference 3Health News:The future of schizophrenia 2Health News:The future of schizophrenia 3Health News:The future of schizophrenia 4Health News:The future of schizophrenia 5
(Date:8/20/2014)... YORK , Aug. 20, 2014 ... is available in its catalogue: Global ... http://www.reportlinker.com/p01375204/Global-Coatings-for-Medical-Devices-Industry.html This report ... Devices in US$ Million by the following Product ... Nanotechnology Coatings. The report provides separate comprehensive analytics ...
(Date:8/20/2014)... and PHOENIX , ... established to bring cutting-edge next-generation sequencing and proteomic ... patients, today announced a collaboration with TESARO, Inc.  ... characterize patient tissue samples from clinical trials to ... resistant to TESARO,s TSR-011.  This may lead to more ...
(Date:8/20/2014)... , Aug. 20, 2014 ApolloDx™ today announced ... platform during a special event at the company,s office ... on September 5, 2014. The event, which will start ... ApolloDx website, www.apollodx.com .    "We ... said Jared Bauer , Co-Founder and Managing Partner ...
Breaking Medicine Technology:Global Coatings for Medical Devices Industry 2Global Coatings for Medical Devices Industry 3Global Coatings for Medical Devices Industry 4Global Coatings for Medical Devices Industry 5Global Coatings for Medical Devices Industry 6Global Coatings for Medical Devices Industry 7Global Coatings for Medical Devices Industry 8Global Coatings for Medical Devices Industry 9Global Coatings for Medical Devices Industry 10Global Coatings for Medical Devices Industry 11Global Coatings for Medical Devices Industry 12Global Coatings for Medical Devices Industry 13Global Coatings for Medical Devices Industry 14Global Coatings for Medical Devices Industry 15Global Coatings for Medical Devices Industry 16Global Coatings for Medical Devices Industry 17Global Coatings for Medical Devices Industry 18Global Coatings for Medical Devices Industry 19Global Coatings for Medical Devices Industry 20Global Coatings for Medical Devices Industry 21Paradigm Announces Molecular Profiling Collaboration with TESARO, Inc. 2
... Inc. (Nasdaq: ENZN) announced today that four,posters containing ... Meeting of the American Association for Cancer Research,(AACR) ... 2007 in Los Angeles, CA., Details of the ... EZN-2208, a novel polyethyleneglycol-SN38,conjugate, has potent antitumor activity ...
... 13, 2007 - Point Therapeutics, Inc.,(NASDAQ: POTP) today ... 2007 Annual Meeting of the American,Association for Cancer ... 14-18, 2007. The AACR poster presentations report,on preclinical ... details for the AACR presentations are as,follows: , ...
Cached Medicine Technology:Enzon to Present Preclinical Data From PEG-SN38 and PEGylation,Technology Studies at AACR Meeting 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: