Navigation Links
The beat goes on: Modeling the human heart
Date:4/10/2013

Computational models of the human heart can be very useful in studying not just the basic mechanisms of heart function, but also to analyze the heart in a diseased state, and come up with methods for diagnosis and therapy.

Dr. Natalia Trayanova's Computational Cardiology Lab at the Johns Hopkins University is doing just thather group uses mathematical models to look at cardiac function and dysfunction, examining the mechanisms behind disorders such as cardiac arrhythmias and pump dysfunction.

In a plenary lecture at the SIAM Conference on Computational Science and Engineering in February, Dr. Trayanova described how her lab uses imaging data from clinics, such as MRIs and CT scans, to create heart models. Using detailed information from such images, the team geometrically constructs 3-D computer models by incorporating information about chemical and protein interactions as well as cardiac fiber orientation.

A normal heart beats at a steady, even rhythm usually between 60 and 100 times a minute. "Cardiac arrhythmia" is a condition caused by a disruption of the normal rhythm of the heart.

Analyzing drug interactions:

Sodium channels are membrane proteins located in cardiac cells, which play a central role in the proper conduction of electrical impulses within the heart, and are hence important for normal cardiac electrical activity. Altered sodium channel function is associated with various arrhythmias, including potentially lethal arrhythmias that result from sodium channel disease.

Given their importance, clinically, drugs for arrhythmia usually target sodium channels. Many drugs used to treat arrhythmia tend to exhibit pro-arrythmic effects while they may cure one component, they can induce another. Hence, clinical trials for arrhythmia drugs have often resulted in more people dying from them than from placebos, says Trayanova. Previously, there has never been a platform to evaluate drug interac
'/>"/>

Contact: Karthika Muthukumaraswamy
karthika@siam.org
267-350-6383
Society for Industrial and Applied Mathematics
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. HHS enlists Archimedes Inc. to expand governments use of health care modeling
2. Modeling the demise of migrating brain tumor cells
3. Modeling sepsis in newborns
4. Modeling Good Research Practices guidelines for modeling in health care research available now
5. NLP Logix Signed to Provide Predictive Modeling Services for Worker Compensation Physical Therapy Provider
6. UK-Based Laminin Solutions and NLP Logix Formalize Agreement to Leverage the Power and Flexibility of M-Files with Big Data Predictive Modeling
7. Home Restoration Services of Minneapolis Receives Houzz’s 2013 ‘Best Of Remodeling’ Award
8. Recon 2 modeling may help tailor treatments for patients with metabolic diseases, cancer
9. New drug prevents spread of human prostate cancer cells
10. Scientists solving the mystery of human consciousness
11. First targeted nanomedicine to enter human clinical studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... July 11, 2014 Recently, Fadhits.com, the distinguished ... of kids prom dresses . To bring more benefits ... has also launched a special offer for these brand new ... 2014. , The company’s sales manager says gladly, “We are ... special offer is to acknowledge all new and old customers ...
(Date:7/11/2014)... Women would benefit from being prescribed exercise as ... moderate to high intensity activity is essential to ... , Professor Debra Anderson, from QUT,s Institute of ... to conventional treatments for physical and mental health, ... for older women. , Professor Anderson and QUT,s ...
(Date:7/11/2014)... New research conducted at Aarhus University has revealed that ... livestock are only half as likely as their urban ... ulcerative colitis and Crohn,s disease. The study findings have ... Epidemiology . , "It is extremely exciting that we ... also more classic inflammatory diseases appear to depend on ...
(Date:7/11/2014)... Emily Johnson, owner of the Portland Fit Body Boot Camp, ... has held two charity workout events and is about to ... 7:15 - 8:30 at Col Summers City Park, SE 20th and ... raised $510 for Medical Teams International. Their second workout event resulted ... On July 26th, Johnson and Portland Fit Body Boot Camp ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Recently, iFitDress.com, ... special occasion outfits, has released its new collection of ... that, the company has announced that all these beautiful ... off. The deadline of the special offer is July ... its major officials pay close attention to customer satisfaction. ...
Breaking Medicine News(10 mins):Health News:Promotion for Kids Prom Dresses Now Provided at Fadhits.com 2Health News:Exercise is the best medicine: QUT study 2Health News:Growing up on a livestock farm halves the risk of inflammatory bowel diseases 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 3Health News:Worldwide Chic Ladies Can Buy Cheap Evening Dresses at iFitDress.com 2
... -- The prestigious BBVA Foundation Frontiers of Knowledge Award ... J. Lefkowitz, M.D., James B. Duke Professor of Medicine ... investigator at Duke University Medical Center. This is only ... Dr. Lefkowitz,s research has affected millions of cardiac and ...
... U.S. Department of Energy,s National Nuclear Security Administration (NNSA) ... of radioisotopes, which are used to help millions of ... cancer, thyroid and heart disease. Earlier this week, ... develop a U.S. supply of Molybdenum-99 (Mo-99). Babcock & ...
... a new generation of products aimed at making cleaning ... in the current issue of Chemical & Engineering News ... Editor Michael McCoy points out in the cover story ... occurring despite a rocky economy in 2009, which led ...
... scent of urine could catch disease quickly , WEDNESDAY, Jan. 27 ... that can detect lung cancer simply on the basis of a ... is so far based solely on work with mice, but follow-up ... in the early diagnosis of lung cancer in humans. , "But ...
... ... regenerates dormant hair follicles to produce new growth is not being recommended by the researchers ... effective hair loss treatment options are already available. , ... (PRWeb UK) January 28, 2010 -- Researchers and hair restoration surgeons ...
... , WASHINGTON , Jan. 27 ... (SCAI) launched "WINHeart -- Score a WIN for Women," ... the diagnosis, treatment and survival of women with cardiovascular ... of interventional cardiologists within SCAI, today released a new ...
Cached Medicine News:Health News:Renowned Duke researcher wins Frontiers of Knowledge Award 2Health News:SNM applauds US Department of Energy's move to develop domestic radioisotope supply 2Health News:New Test Might 'Smell' Early Stage Lung Cancer 2Health News:New Test Might 'Smell' Early Stage Lung Cancer 3Health News:Hair Cloning Not Yet Recommended by Researchers Who Developed the Technique 2Health News:New Report and Survey Findings Highlight Why More Women Die From Heart Disease Than Men 2Health News:New Report and Survey Findings Highlight Why More Women Die From Heart Disease Than Men 3Health News:New Report and Survey Findings Highlight Why More Women Die From Heart Disease Than Men 4Health News:New Report and Survey Findings Highlight Why More Women Die From Heart Disease Than Men 5
(Date:7/10/2014)...   Ventana Medical Systems, Inc.  (Ventana), a member ... into an agreement with Merck KGaA, Darmstadt, ... the United States and ... biopharmaceutical division on the development and commercialization of a ... proprietary diagnostic assays. In alignment with Merck KGaA,s strategic ...
(Date:1/15/2014)... Jan. 15, 2014 Sono-Tek Corporation (OTC BB: SOTK) today ... 30, 2013, compared to sales of $2,202,000 for the prior ... this quarter has also shown growth over the preceding quarter,s ... of this fiscal year. Markets that experienced sales increases over ...
(Date:1/15/2014)... 15, 2014 AARP Foundation today announced it has established ... from the severe cold weather that has gripped much of ... those in need; so to support these emergency relief efforts ... $250,000, which could mean up to $500,000 in aid. The ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... Calif., Oct. 1 NeurogesX, Inc. (Nasdaq: NGSX ... novel pain management therapies, announced today that Anthony DiTonno, ... at the Fourth Annual JMP Securities Healthcare Focus Conference, ... New York City. , Mr. DiTonno and Stephen Ghiglieri, ...
... Oct. 1 The Prix Galien USA committee celebrated ... for the development and discovery of drugs and technologies ... and Veridex were honored with the 2009 Prix Galien ... and development, for treatments that could change the course ...
Cached Medicine Technology:NeurogesX to Present at JMP Securities Healthcare Focus Conference 2NeurogesX to Present at JMP Securities Healthcare Focus Conference 3Prix Galien USA Honors Innovation in Science and Biotech Industries 2
... Medical Professional Diagnostics is a leading provider ... and DFA test menu that includes kits ... as well as miscellaneous conjugates and components. ... a wide assortment of substrates and kit ...
... Medical Professional Diagnostics is a leading provider ... and DFA test menu that includes kits ... as well as miscellaneous conjugates and components. ... a wide assortment of substrates and kit ...
... Medical Professional Diagnostics is a leading provider ... and DFA test menu that includes kits ... as well as miscellaneous conjugates and components. ... a wide assortment of substrates and kit ...
... Inverness Medical Professional Diagnostics is a leading ... IFA and DFA test menu that includes ... STDs as well as miscellaneous conjugates and ... you a wide assortment of substrates and ...
Medicine Products: