Navigation Links
The balance shifts
Date:5/27/2008

The risk of contracting a Clostridium difficile infection following operations for which a "prophylactic" antibiotic is given to prevent infection is 21 times greater now than it was just a decade ago, according to researchers from the University of Sherbrooke in Canada. They report their findings in the June 15 issue of Clinical Infectious Diseases, currently available online.

Surgical operations that have been associated with severe infections, such as open heart surgeries and prosthetic implants, are often accompanied by the simultaneous administration of antibiotics, a strategy which has successfully reduced the number of infections. A consequence of this antimicrobial therapy is a modification in normal flora of the human intestine. In this altered environment, a bacterium named Clostridium difficile can thrive. An infection with C. difficile can cause severe diarrhea, occasionally leading to death.

Historically, the benefits of preventing surgical site infections have outweighed the relatively minor risk of C. difficile infections. However, in 2000 a hypervirulent strain of C. difficile emerged, leading to a dramatic increase in the number of infections and in the severity of those infections.

Researchers from the University of Sherbrooke recently completed a study that calculated the risk of contracting a C. difficile infection when the sole antibiotic given was prophylaxis accompanying surgery and compared the current risk with the risk from a period before the emergence of the hypervirulent strain. They found a 21-fold increase in the risk, from 0.07 percent of patients to 1.5 percent. Of the 40 patients who developed a C. difficile infection after peri-operative antibiotic prophylaxis, 5 either died or developed septic shock. Cefoxitin was most likely to be associated with the contraction of a C. difficile infection.

Because the outcomes of C. difficile infections can be severe, the authors suggested that cases be individually evaluated and if the purpose of the antibiotic therapy is only to prevent infrequent or relatively benign infections, then the risks may outweigh benefits. This may be particularly important with elderly patients, who fare worse with C. difficile infections than do younger people.

In addition, the studys lead author, Louis Valiquette, MD, MSc, suggested that surgical antibiotic prophylaxis should be used for the shortest duration possible to minimize the risk of C. difficile infection. This would also produce collateral benefits of decreasing cost, reducing microbial-related side effects, and slowing the development of bacterial resistance.


'/>"/>

Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0412
Infectious Diseases Society of America
Source:Eurekalert

Related medicine news :

1. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
2. A chocolate cookie a day puts 20 pounds on an energetically-balanced kid in 4 years
3. Study expected to boost research for hearing and balance therapies
4. Decision-makers seek internal balance, not balanced alternatives
5. Smart Balance Announces Third Quarter 2007 Results
6. Complementary medicines training provides balance, not bias
7. Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
8. Evolution Tips the Balance in Moms Favor
9. Smart Balance Announces Conversion of Convertible Preferred Stock
10. Physical Therapist Intervention for Balance Impairments May Help Reduce Risk of Falling
11. MedeFile Materially Strengthens Balance Sheet Through Equity Financing and Debt Conversion Totaling $4 Million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... Chapel, FL (PRWEB) , ... October 12, 2017 , ... ... is holding a treadmill relay – Miles by Moonlight to raise money for the ... donating $300 or more. , Teams will work together to keep their treadmills ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 West ... in innovative solutions for injectable drug administration, today announced ... the market opens on Thursday, October 26, 2017, and ... results and business expectations at 9:00 a.m. Eastern Time. ... or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an update ... Puerto Rico , where the company manufactures ... Following a comprehensive onsite assessment, the ... temporary loss of power and minimal water damage due ... have resumed, and the company expects to return to ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
Breaking Medicine Technology: