Navigation Links
The balance shifts
Date:5/27/2008

The risk of contracting a Clostridium difficile infection following operations for which a "prophylactic" antibiotic is given to prevent infection is 21 times greater now than it was just a decade ago, according to researchers from the University of Sherbrooke in Canada. They report their findings in the June 15 issue of Clinical Infectious Diseases, currently available online.

Surgical operations that have been associated with severe infections, such as open heart surgeries and prosthetic implants, are often accompanied by the simultaneous administration of antibiotics, a strategy which has successfully reduced the number of infections. A consequence of this antimicrobial therapy is a modification in normal flora of the human intestine. In this altered environment, a bacterium named Clostridium difficile can thrive. An infection with C. difficile can cause severe diarrhea, occasionally leading to death.

Historically, the benefits of preventing surgical site infections have outweighed the relatively minor risk of C. difficile infections. However, in 2000 a hypervirulent strain of C. difficile emerged, leading to a dramatic increase in the number of infections and in the severity of those infections.

Researchers from the University of Sherbrooke recently completed a study that calculated the risk of contracting a C. difficile infection when the sole antibiotic given was prophylaxis accompanying surgery and compared the current risk with the risk from a period before the emergence of the hypervirulent strain. They found a 21-fold increase in the risk, from 0.07 percent of patients to 1.5 percent. Of the 40 patients who developed a C. difficile infection after peri-operative antibiotic prophylaxis, 5 either died or developed septic shock. Cefoxitin was most likely to be associated with the contraction of a C. difficile infection.

Because the outcomes of C. difficile infections can be severe, the authors suggested that cases be individually evaluated and if the purpose of the antibiotic therapy is only to prevent infrequent or relatively benign infections, then the risks may outweigh benefits. This may be particularly important with elderly patients, who fare worse with C. difficile infections than do younger people.

In addition, the studys lead author, Louis Valiquette, MD, MSc, suggested that surgical antibiotic prophylaxis should be used for the shortest duration possible to minimize the risk of C. difficile infection. This would also produce collateral benefits of decreasing cost, reducing microbial-related side effects, and slowing the development of bacterial resistance.


'/>"/>

Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0412
Infectious Diseases Society of America
Source:Eurekalert

Related medicine news :

1. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
2. A chocolate cookie a day puts 20 pounds on an energetically-balanced kid in 4 years
3. Study expected to boost research for hearing and balance therapies
4. Decision-makers seek internal balance, not balanced alternatives
5. Smart Balance Announces Third Quarter 2007 Results
6. Complementary medicines training provides balance, not bias
7. Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
8. Evolution Tips the Balance in Moms Favor
9. Smart Balance Announces Conversion of Convertible Preferred Stock
10. Physical Therapist Intervention for Balance Impairments May Help Reduce Risk of Falling
11. MedeFile Materially Strengthens Balance Sheet Through Equity Financing and Debt Conversion Totaling $4 Million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... 2017 , ... Hernandez Insurance Agencies, a northern Virginia firm ... DC region, is inaugurating a “New Leash On Life” charity initiative in conjunction ... to be companions for veterans in need. , The Semper K9 organization works ...
(Date:8/18/2017)... ... 18, 2017 , ... Goss & Associates Insurance Agency, a ... clients in the greater Houston region, is helping locally recognized nonprofit Addi’s Faith ... cancer. , Founded by Tony and Amber Bender after losing their young daughter ...
(Date:8/18/2017)... ... August 18, 2017 , ... Alcovit, a lime-flavored beverage that rids ... marketing efforts with its product now available through Jet.com. , After 25 years ... effervescent powdered drink is designed to quickly detox the body thereby avoiding alcohol-induced hangovers. ...
(Date:8/18/2017)... ... ... “Three Narrow Roads”: a vivid and provocative look into the narrow path toward god. ... is currently the pastor-teacher-visionary at Simply the WORD Church, a global prayer ministry and ... geared towards youth. , King shares, “When I take time to think about the ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Prompted By Love”: a love ... of published author, Mary Nettles. Author Mary P. Nettles has devoted her life ... VBS teacher. Her lifelong desire to write was, however, not fulfilled until 2014 ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... 2017  Opioid addiction and other drugs of abuse, ... and threatening outcomes, were problems taken on directly as ... that support them, met this week. This according to ... drugs of abuse, procalcitonin and acute kidney injury were ... 69th meeting in San Diego, CA. ...
(Date:8/2/2017)... 2017 CaryRx, a next-generation full-service pharmacy, has announced ... patients in the Washington D.C. metropolitan ... providing delivery of medications through the convenience of its patient-friendly ... delivered within one hour to any location in D.C. ... this invaluable service to Washington D.C. ," says ...
(Date:7/31/2017)... July 31, 2017 7D Surgical, developer of ground ... purchased the 7D Surgical System to support its strategic sales ... D.C. and Virginia.  7D Surgical has entered into ... of the premier medical facilities within those markets. ... ...
Breaking Medicine Technology: