Navigation Links
The balance shifts
Date:5/27/2008

The risk of contracting a Clostridium difficile infection following operations for which a "prophylactic" antibiotic is given to prevent infection is 21 times greater now than it was just a decade ago, according to researchers from the University of Sherbrooke in Canada. They report their findings in the June 15 issue of Clinical Infectious Diseases, currently available online.

Surgical operations that have been associated with severe infections, such as open heart surgeries and prosthetic implants, are often accompanied by the simultaneous administration of antibiotics, a strategy which has successfully reduced the number of infections. A consequence of this antimicrobial therapy is a modification in normal flora of the human intestine. In this altered environment, a bacterium named Clostridium difficile can thrive. An infection with C. difficile can cause severe diarrhea, occasionally leading to death.

Historically, the benefits of preventing surgical site infections have outweighed the relatively minor risk of C. difficile infections. However, in 2000 a hypervirulent strain of C. difficile emerged, leading to a dramatic increase in the number of infections and in the severity of those infections.

Researchers from the University of Sherbrooke recently completed a study that calculated the risk of contracting a C. difficile infection when the sole antibiotic given was prophylaxis accompanying surgery and compared the current risk with the risk from a period before the emergence of the hypervirulent strain. They found a 21-fold increase in the risk, from 0.07 percent of patients to 1.5 percent. Of the 40 patients who developed a C. difficile infection after peri-operative antibiotic prophylaxis, 5 either died or developed septic shock. Cefoxitin was most likely to be associated with the contraction of a C. difficile infection.

Because the outcomes of C. difficile infections can be severe, the authors suggested that cases be individually evaluated and if the purpose of the antibiotic therapy is only to prevent infrequent or relatively benign infections, then the risks may outweigh benefits. This may be particularly important with elderly patients, who fare worse with C. difficile infections than do younger people.

In addition, the studys lead author, Louis Valiquette, MD, MSc, suggested that surgical antibiotic prophylaxis should be used for the shortest duration possible to minimize the risk of C. difficile infection. This would also produce collateral benefits of decreasing cost, reducing microbial-related side effects, and slowing the development of bacterial resistance.


'/>"/>

Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0412
Infectious Diseases Society of America
Source:Eurekalert

Related medicine news :

1. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
2. A chocolate cookie a day puts 20 pounds on an energetically-balanced kid in 4 years
3. Study expected to boost research for hearing and balance therapies
4. Decision-makers seek internal balance, not balanced alternatives
5. Smart Balance Announces Third Quarter 2007 Results
6. Complementary medicines training provides balance, not bias
7. Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
8. Evolution Tips the Balance in Moms Favor
9. Smart Balance Announces Conversion of Convertible Preferred Stock
10. Physical Therapist Intervention for Balance Impairments May Help Reduce Risk of Falling
11. MedeFile Materially Strengthens Balance Sheet Through Equity Financing and Debt Conversion Totaling $4 Million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... Splashtop Inc., ... its strategic partnership with e-Jan Networks Co., the leading provider of secure mobile ... customers of e-Jan Networks’s leading CACHATTO remote access solution. Splashtop for ...
(Date:5/31/2016)... ... May 31, 2016 , ... Twenty years ago it was revolutionary: enabling the ... silence the voices they hear. But this approach has proven transformative, both for people ... steadily gained credibility and now is used around the world, but it still lags ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... Corporation, he knew it was something that contractors should have at their disposal ... it gets,” says Butch, CertainTeed’s Director of Contractor Programs. , As a ...
(Date:5/31/2016)... ... May 31, 2016 , ... CallTrackingMetrics's software gives ... monitor the performance of sales and support staff, and to efficiently route calls ... allows customers to record, transcribe, route, document, and report on everything going on ...
(Date:5/31/2016)... Newport Beach, Calif. (PRWEB) , ... May 31, 2016 , ... ... trust among colleagues, clients, and the industry as a whole. On June 2, Northbound ... Coast Symposium on Addictive Disorders (WCSAD) and presenting the opening plenary on “Leadership: The ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... VALLEY COTTAGE, New York , May 31, 2016 ... traction as an essential ingredient in food, cosmetics and ... 2016 end, representing revenues worth US$ 1.6 Bn. ... vera gels, cosmetics products, juices, and yogurts will continue ... health and wellness trend will also boost positive sentiment ...
(Date:5/31/2016)... May 31, 2016 , Isansys  Lifecare, ... its Patient Status Engine wireless patient monitoring platform, as it ... Germany , Scotland and ... 2 nd generation system, launched earlier this year, is now ... , , This new technology significantly enhances ...
(Date:5/30/2016)... , May 30, 2016 ... report "Healthcare Biometrics Market by Technology (Single-factor ... Multifactor, Multimodal), Application (Workforce Management), End User ... 2021", published by MarketsandMarkets, the market is ... 2021 from USD 1,182.6 Million by 2016, ...
Breaking Medicine Technology: